In Vitro Validation of 4D Flow MRI for Local Pulse Wave Velocity Estimation
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Arterial stiffness has predictive value for cardiovascular disease (CVD). Local artery stiffness can provide insight on CVD pathology and may be useful for diagnosis and prognosis. However, current methods are invasive, require real-time expertise for measurement, or are limited by arterial region. 4D Flow MRI can non-invasively measure local stiffness by estimating local pulse wave velocity (PWV). This technique can be applied to vascular regions, previously accessible only by invasive stiffness measurement methods. MRI PWV data can also be analyzed post-exam. However, 4D Flow MRI requires validation before it is used in vivo to measure local PWV.
PWV, calculated from 4D Flow MRI and a benchtop experiment, was compared with petersons elastic modulus (PEM) of in vitro models. PEM was calculated using high-speed camera images and pressure transducers. Three transit-time algorithms were analyzed for PWV measurement accuracy and precision.
PWV from 4D Flow MRI and reference benchtop experiments show strong correlation with PEM (R2 = 0.99). The cross correlation transit-time algorithm showed the lowest percent difference between 4D Flow MRI and benchtop experiments (4–7%), and the point to point of 50% upstroke algorithm had the highest transit-time vs. distance data average R2 (0.845).
4D Flow MRI is a feasible method for estimating local PWV in simple in vitro models and is a viable tool for clinical analysis. In addition, choice in transit-time algorithm depends on flow waveform shape and arterial region. This study strengthens the validity of 4D Flow MRI local PWV measurement in simple models. However, this technique requires validation in more complex models before it is used in vivo.
KeywordsLocal pulse wave velocity 4D FLOW MRI Arterial stiffness Validation
Conflict of interest
Timothy Ruesink, David Rutkowski, Rafael Medero and Alejandro Roldán-Alzate declare that they have no conflict of interest.
Research Involving Human and Animal Participants
No human studies were carried out by the authors for this article. No animal studies were carried out by the authors for this article.
- 4.Boutouyrie, P., D. Fliser, D. Goldsmith, A. Covic, A. Wiecek, A. Ortiz, et al. Assessment of arterial stiffness for clinical and epidemiological studies: methodological considerations for validation and entry into the European Renal and Cardiovascular Medicine registry. Nephrol. Dial. Transplant. 29:232–239, 2014.CrossRefGoogle Scholar
- 8.Dogui, A., N. Kachenoura, F. Frouin, M. Lefort, A. De Cesare, E. Mousseaux, et al. Consistency of aortic distensibility and pulse wave velocity estimates with respect to the Bramwell-Hill theoretical model: a cardiovascular magnetic resonance study. J. Cardiovasc. Magn. Reson. 13(1):11, 2011.CrossRefGoogle Scholar
- 10.Gu, T., F. R. Korosec, W. F. Block, S. B. Fain, Q. Turk, D. Lum, et al. PC VIPR: a high-speed 3D phase-contrast method for flow quantification and high-resolution angiography. Am. J. Neuroradiol. 26:743–749, 2005.Google Scholar
- 18.Markl, M., W. Wallis, C. Strecker, B. P. Gladstone, W. Vach, and A. Harloff. Analysis of pulse wave velocity in the thoracic aorta by flow-sensitive four-dimensional MRI: reproducibility and correlation with characteristics in patients with aortic atherosclerosis. J. Magn. Reson. Imaging. 35:1162–1168, 2012.CrossRefGoogle Scholar
- 29.Taviani, V., A. J. Patterson, M. J. Graves, C. J. Hardy, P. Worters, M. P. F. Sutcliffe, et al. Accuracy and repeatability of fourier velocity encoded M-mode and two-dimensional cine phase contrast for pulse wave velocity measurement in the descending aorta. J. Magn. Reson. Imaging. 31:1185–1194, 2010.CrossRefGoogle Scholar
- 30.Tijsseling, A., and A. A. Anderson. Isebree Moens and DJ Korteweg: On the Speed of Propagation of Waves in Elastic Tubes. BHR Gr: Conf Press Surges, pp. 1–19, 2012.Google Scholar
- 32.Van Sloten, T. T., M. T. Schram, K. Van Den Hurk, J. M. Dekker, G. Nijpels, R. M. A. Henry, et al. Local stiffness of the carotid and femoral artery is associated with incident cardiovascular events and all-cause mortality: the hoorn study. J. Am. Coll. Cardiol. 63:1739–1747, 2014.CrossRefGoogle Scholar
- 34.Wang, Z., Y. Yang, L. J. Yuan, J. Liu, Y. Y. Duan, and T. S. Cao. Noninvasive method for measuring local pulse wave velocity by dual pulse wave Doppler: in vitro and in vivo studies. PLoS ONE. 10:1–13, 2015.Google Scholar
- 35.Wentland, A. L., T. M. Grist, and O. Wieben. Review of MRI-based measurements of pulse wave velocity: a biomarker of arterial stiffness. Cardiovasc. Diagn. Ther. 4:193–206, 2014.Google Scholar
- 37.Westenberg, J. J. M., E. P. Van Poelgeest, P. Steendijk, H. B. Grotenhuis, J. W. Jukema, and A. De Roos. Bramwell-Hill modeling for local aortic pulse wave velocity estimation: a validation study with velocity-encoded cardiovascular magnetic resonance and invasive pressure assessment. J. Cardiovasc. Magn. Reson. 14:2, 2012.CrossRefGoogle Scholar
- 38.World Health Organization. Cardiovascular diseases [Internet]. 2017 [cited 2018 Mar 4]. p. 1–6. http://www.who.int/mediacentre/factsheets/fs317/en/.