Tonghua Liu: A life dedicated to clinical pathology
- 302 Downloads
Prof. Liu was born on November 13th, 1929 in Wuxi, Jiangsu Province. She studied at the Medical School of Saint John’s University in Shanghai from 1947 to 1953 (Fang et al., 2009).
In 1953, Liu graduated from Prof. Hu’s program. She became a teaching assistant at the 6th Army Medical University and was there from 1953–1954. In the following two years she worked for the 7th Army Medical University as a teaching assistant. Today the 6th and the 7th Army Medical Universities are now known as the 3rd Army Medical University (Fang et al., 2009).
In 1957, the Pathology Department of PUMC was merged with the Experimental Medicine Institute at the Chinese Academy of Medical Sciences (CAMS). From 1957 to 1969 Liu worked as both a teaching assistant at the Pathology Department of PUMC and a teaching assistant and assistant researcher at the Pathology Department at the Experimental Medicine Institute of CAMS. In 1969, the Experimental Medicine Institute moved to Jianyang, Sichuan Province. As a spouse of an army man, Liu could not separate from her husband. Thus she decided to stay in Beijing to found a separate Pathology Department in PUMCH (Duan et al., 2016).
The Pathology Department of PUMCH started from scratch. Almost all equipment and archives, including all autopsy files and gross specimen, had been moved to Jianyang. All that was left was a few office rooms and two technicians. Liu insisted that the 270,000 clinical pathological archives should be left to PUMCH, “Clinical pathological archives are critical to clinical studies. In order to make the best use of them, these files should be given to PUMCH.” A few years later, the previous autopsy archives were also transported back from Jianyang to Beijing (Liu, 2010). These documents were invaluable to the development of clinical pathology in PUMCH, and pathology in China in general. Because of Prof. Liu’s dedication, PUMCH now housed over 11 million pathological archives dating all the way back to 1916. The PUMCH pathological archive is a testament to Prof. Liu’s professionalism (Duan et al., 2016).
Prof. Liu was appointed deputy director of the Pathology Department of PUMCH in 1978 and then director in 1985 (PUMCH, 2018). Prof. Liu overcame great challenges so that the Pathology Department of PUMCH could grow and thrive. She voluntarily took over part of the technicians’ duties when the lab was severely understaffed during the initial years. She would come to the lab at 7 am every day to embed paraffin. This would allow the technicians to slice the paraffin and make section specimen at 8 am. After that, Liu would assess a great number of slices and generate reports. She always stayed late to review literature on difficult cases. Prof. Liu’s diligence has become a tradition in the Pathology Department of PUMCH (Duan et al., 2016).
Prof. Liu signed her name on almost 1 million clinical pathology reports during her 65-year career. She always gave definitive diagnosis, embodying her capable and decisive temperament. Prof. Liu was famous for diagnosing rare and difficult cases, especially in the field of lymph nodes, digestive and endocrine diseases. Her diagnosis was held as the “golden standard” across the country. In the 1990s, Prof. Liu was consulted and made a diagnosis of cervical lymph node metastatic squamous cell carcinoma. After receiving Prof. Liu’s report, doctors examined the patient carefully, seeking to identify the primary tumor lesion. However, they found nothing and doubted Prof. Liu’s diagnosis. The doctors requested Prof. Liu review the case again. After re-reviewing the case, Prof. Liu’s diagnosis remained unchanged but she added 4 words to her report, “examine patient’s oral cavity.” At last, doctors were able to find an unconspicuous primary tumor lesion on the patient’s gum. When it came to diagnosis, her suggestion had ascended from science to art (Duan et al., 2016).
Prof. Liu always believed in drawing on the PUMCH tradition of combining basic sciences with clinical research. In the 1980s and 1990s, her team achieved a series of innovative breakthroughs on molecular biology and molecular genetics of pancreatic carcinoma and pancreatic neuroendocrine tumours (PNET). Her team’s study on “Pancreatic Dead Carcinoma’s Ring Invasion into Intrapancreatic Bile Duct Wall” won the Second Prize of Science and Technology Progress Award of the National Health Commission in 1985 (Liu et al., 1983). Her team won another Second Prize of Science and Technology Progress Award of the National Health Commission in 1993 for their study of “Molecular Biology of Human Pancreatic Carcinoma Cell and Reversal of its Malignant Phenotype by Antisense Gene Regulation” (Chen et al., 1993). Another study on “Antisense Gene Regulation Reverse Malignant Phenotype of Human Pancreatic Carcinoma Cell” won the Second Prize of the National Science and Technology Progress Award in 1995 (Liu et al., 1995). In 1999, Prof. Liu was elected the academician of the Chinese Academy of Engineering for her outstanding achievements in pathogenesis and gene therapeutics of pancreatic carcinoma. She was the first pathologist to be elected as an academician of the Chinese Academy of Engineering (PUMCH, 2018).
Prof. Liu was an executive editor of the third and fourth editorial board of the Chinese Journal of Pathology, and the honorary editor-in-chief of its eighth editorial board (Huo et al., 2009). She was also the honorary editor-in-chief of Chinese Journal of Diagnostic Pathology (Liu, 2014) and a member of the standing committee of the Society of Pathology, Chinese Medical Association. She published more than 400 theses and was chief editor of four academic books. Diagnostic Pathology was issued under her general editorship in 1994. It won the National Excellent Science and technology Book Award in 1995. This book has since become an essential reference for all Chinese clinical pathologists (PUMCH, 2018). In memorial of Prof. Liu’s contribution, the fourth edition of the book was renamed to Liu Tonghua Diagnostic Pathology (Dong & Pang, 2018).
Prof. Liu also won many other titles and awards including the National Distinguished Teacher & Beijing Distinguished Teacher award in 1995, Expert of Outstanding Contribution by National Health Commission in 1998, Capital Labor Medal in 2003, Distinguished Worker from the China Association for Science and Technology, Beijing March 8 Red Flag Bearer, Beijing Patriotic and Contributing Model, Renowned Doctor of PUMCH, Distinguished Contribution Award and Distinguished Expert from PUMCH etc. (PUMCH, 2018).
- Chen J, Liu T, Wang Z, Cui Q, Zeng C, Wang D, Gao J (1993) Expression of transforming growth factor and c-erbB-2 gene on human pancreatic carcinoma cell. Chin J Oncol 15(4):273–277Google Scholar
- Dong L, Pang J (2018) Launching ceremony of Tonghua Liu Diagnostic Pathology took place in Chengdu. PUMCH Newspaper, 2018-11-12. (董琳, 庞钧译(2018),《刘彤华诊断病理学》新书首发式在蓉举行, 北京协和医院院报, 2018-11-12)Google Scholar
- Duan W, Liang Z, Dong L, Pang J (2016) Tonghua Liu: A Life on the 7 cm Microslide, China Science Daily 2016-6-20. (段文利, 梁智勇, 董琳, 庞钧译(2016), 刘彤华:七厘米载玻片上的医学人生, 中国科学报, 2016-6-20)Google Scholar
- Fang W, Cui Q, Liang Z, Duan W, Yang D (2009) As is our pathology, so is our Medicine! Biography-in-photo of Tonghua Liu at her 80th birthday, Peking Union Medical College Hospital (Internal publications). (方文钧等主编(2009), 彤映华章——刘彤华教授八十华诞纪念画册, 北京协和医院内部刊物)Google Scholar
- Huo L, Cai Z, Chang X, Qi W (2009) Prof. Tonghua Liu’s greatest contribution to Chinese Journal of Pathology is her diligence, devotion and sense of responsibility. China Medical News, Nov 27, 2009. (霍临明、蔡振国、常秀青、齐文安(2009), 用勤奋、敬业、责任心撑起学术天空——记为《中华病理学杂志》发展做出突出贡献的刘彤华院士, 中华医学信息导报, 2009-9-27)Google Scholar
- Liu T (2008) Pathology in the era of personalized medicine. Chin J Pathol 37(4):217–218. (刘彤华(2008), 个性化医学时代的病理学, 中华病理学杂志, 37(4):217–218)Google Scholar
- Liu T (2010) 40th anniversary of the Pathology Department of PUMCH, Peking Union Medical College Hospital. Med J 01(1):1–4. (刘彤华(2010), 北京协和医院病理科建科40周年, 协和医学杂志, 01(1):1–4)Google Scholar
- Liu T (2014) Wish you further and greater progress: on the occasion of Chinese Journal of Diagnostic Pathology’s 20th anniversary. J Diag Pathol 21(6):330. (刘彤华(2014), 百尺竿头更进一步——写在《诊断》病理学杂志创刊20周年之际, 诊断病理学, 21(6):330)Google Scholar
- PUMCH (2018) A biography of Tonghua Liu. PUMCH Newspaper, 2018-7-30. (刘彤华院士生平简介, 北京协和医院院报, 2018-7-30)Google Scholar
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.