Protein & Cell

, Volume 4, Issue 12, pp 904–910 | Cite as

Mutual regulation between Hippo signaling and actin cytoskeleton

  • Yurika Matsui
  • Zhi-Chun LaiEmail author
Review Protein & Cell


Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation, apoptosis, and differentiation. How Hippo signaling is regulated has been under extensive investigation. Over the past three years, an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector, Yki/Yap/Taz. On the other hand, Hippo signaling negatively regulates actin cytoskeleton organization. This review provides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development, and points out outstanding questions for further investigations.


Hippo signaling actin cytoskeleton negative feedback growth control development 


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Intercollege Graduate Degree Program in Cell and Developmental BiologyThe Pennsylvania State UniversityUniversity ParkUSA
  2. 2.Department of BiologyThe Pennsylvania State UniversityUniversity ParkUSA
  3. 3.Department of Biochemistry and Molecular BiologyThe Pennsylvania State UniversityUniversity ParkUSA

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