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Protein & Cell

, Volume 4, Issue 10, pp 735–746 | Cite as

The evolving landscape in the therapy of acute myeloid leukemia

  • Grace L. Peloquin
  • Yi-Bin Chen
  • Amir T. FathiEmail author
Review Protein & Cell

Abstract

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of myeloid precursors arrested in their maturation, creating a diverse disease entity with a wide range of responses to historically standard treatment approaches. While significant progress has been made in characterizing and individualizing the disease at diagnosis to optimally inform those affected, progress in treatment to reduce relapse and induce remission has been limited thus far. In addition to a brief summary of the factors that shape prognostication at diagnosis, this review attempts to expand on the current therapies under investigation that have shown promise in treating AML, including hypomethylating agents, gemtuzumab ozogamicin, FLT3 tyrosine kinase inhibitors, antisense oligonucleotides, and other novel therapies, including aurora kinases, mTOR and PI3 kinase inhibitors, PIM kinase inhibitors, HDAC inhibitors, and IDH targeted therapies. With these, and undoubtedly many others in the future, it is the hope that by combining more accurate prognostication with more effective therapies, patients will begin to have a different, and more complete, outlook on their disease that allows for safer and more successful treatment strategies.

Keywords

acute myeloid leukemia hypomethylating FLT3 gemtuzumab ozogamicin 

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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Grace L. Peloquin
    • 1
  • Yi-Bin Chen
    • 1
  • Amir T. Fathi
    • 1
    Email author
  1. 1.Massachusetts General Hospital Cancer CenterHarvard Medical SchoolBostonUSA

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