Protein & Cell

, Volume 3, Issue 3, pp 173–181

Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis

Review
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Abstract

Atherosclerosis is a chronic, inflammatory disorder characterized by the deposition of excess lipids in the arterial intima. The formation of macrophage-derived foam cells in a plaque is a hallmark of the development of atherosclerosis. Lipid homeostasis, especially cholesterol homeostasis, plays a crucial role during the formation of foam cells. Recently, lipid droplet-associated proteins, including PAT and CIDE family proteins, have been shown to control the development of atherosclerosis by regulating the formation, growth, stabilization and functions of lipid droplets in macrophage-derived foam cells. This review focuses on the potential mechanisms of formation of macrophage-derived foam cells in atherosclerosis with particular emphasis on the role of lipid homeostasis and lipid droplet-associated proteins. Understanding the process of foam cell formation will aid in the future discovery of novel therapeutic interventions for atherosclerosis.

Keywords

macrophage foam cell atherosclerosis cholesterol lipid droplet-associated proteins 

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© Higher Education Press and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Pathology, Xijing HospitalFourth Military Medical UniversityXi’anChina
  2. 2.Tsinghua-Peking Center for Life Sciences, School of Life SciencesTsinghua UniversityBeijingChina

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