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Study of drug function based on similarity of pathway fingerprint

Protein & Cell volume 3, pages132–139(2012)Cite this article

Abstract

Drugs sharing similar therapeutic function may not bind to the same group of targets. However, their targets may be involved in similar pathway profiles which are associated with certain pathological process. In this study, pathway fingerprint was introduced to indicate the profile of significant pathways being influenced by the targets of drugs. Then drug-drug network was further constructed based on significant similarity of pathway fingerprints. In this way, the functions of a drug may be hinted by the enriched therapeutic functions of its neighboring drugs. In the test of 911 FDA approved drugs with more than one known target, 471 drugs could be connected into networks. 760 significant associations of drug-therapeutic function were generated, among which around 60% of them were supported by scientific literatures or ATC codes of drug functional classification. Therefore, pathway fingerprints may be useful to further study on the potential function of known drugs, or the unknown function of new drugs.

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Author information

Affiliations

  1. State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai, 200237, China

    Hao Ye, Linlin Yang & Yixue Li

  2. Shanghai Center for Bioinformation Technology, Shanghai, 200235, China

    Hao Ye, Kailin Tang, Linlin Yang & Yixue Li

  3. School of Life Science and Technology, Tongji University, Shanghai, 200092, China

    Zhiwei Cao

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  1. Hao Ye
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  2. Kailin Tang
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  3. Linlin Yang
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  4. Zhiwei Cao
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  5. Yixue Li
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Correspondence to Yixue Li.

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Ye, H., Tang, K., Yang, L. et al. Study of drug function based on similarity of pathway fingerprint. Protein Cell 3, 132–139 (2012). https://doi.org/10.1007/s13238-012-2011-z

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Keywords

  • pathway fingerprint
  • drug-drug network
  • therapeutic target
  • function prediction