Advertisement

Protein & Cell

, Volume 3, Issue 2, pp 81–83 | Cite as

“Smurf”-ing tumors on the chromatin through RNF20

  • Wen-Wei TsaiEmail author
News and Views
  • 148 Downloads

References

  1. Chandrasekharan, M.B., Huang, F., and Sun, Z.W. (2009). Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Proc Natl Acad Sci U S A 106, 16686–16691.PubMedCentralCrossRefPubMedGoogle Scholar
  2. Chandrasekharan, M.B., Huang, F., and Sun, Z.W. (2010). Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation. Epigenetics 5, 460–468.PubMedCentralCrossRefPubMedGoogle Scholar
  3. Fierz, B., Chatterjee, C., McGinty, R.K., Bar-Dagan, M., Raleigh, D.P., and Muir, T.W. (2011). Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nat Chem Biol 7, 113–119.PubMedCentralCrossRefPubMedGoogle Scholar
  4. Fukuchi, M., Fukai, Y., Masuda, N., Miyazaki, T., Nakajima, M., Sohda, M., Manda, R., Tsukada, K., Kato, H., and Kuwano, H. (2002). High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma. Cancer Res 62, 7162–7165.PubMedGoogle Scholar
  5. Jason, L.J., Moore, S.C., Lewis, J.D., Lindsey, G., and Ausió, J. (2002). Histone ubiquitination: a tagging tail unfolds? Bioessays 24, 166–174.CrossRefPubMedGoogle Scholar
  6. Jin, C., Yang, Y.A., Anver, M.R., Morris, N., Wang, X., and Zhang, Y.E. (2009). Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness. Cancer Res 69, 735–740.PubMedCentralCrossRefPubMedGoogle Scholar
  7. Kouzarides, T. (2007). Chromatin modifications and their function. Cell 128, 693–705.CrossRefPubMedGoogle Scholar
  8. Misteli, T. (2007). Beyond the sequence: cellular organization of genome function. Cell 128, 787–800.CrossRefPubMedGoogle Scholar
  9. Narimatsu, M., Bose, R., Pye, M., Zhang, L., Miller, B., Ching, P., Sakuma, R., Luga, V., Roncari, L., Attisano, L., et al. (2009). Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell 137, 295–307.CrossRefPubMedGoogle Scholar
  10. Shema, E., Tirosh, I., Aylon, Y., Huang, J., Ye, C., Moskovits, N., Raver-Shapira, N., Minsky, N., Pirngruber, J., Tarcic, G., et al. (2008). The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev 22, 2664–2676.PubMedCentralCrossRefPubMedGoogle Scholar
  11. Yamashita, M., Ying, S.X., Zhang, G.M., Li, C., Cheng, S.Y., Deng, C. X., and Zhang, Y.E. (2005). Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121, 101–113.PubMedCentralCrossRefPubMedGoogle Scholar
  12. Zhang, H., Teng, Y., Kong, Y., Kowalski, P.E., and Cohen, S.N. (2008). Suppression of human tumor cell proliferation by Smurf2-induced senescence. J Cell Physiol 215, 613–620.CrossRefPubMedGoogle Scholar

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Peptide Biology LaboratoriesSalk Institute for Biological StudiesLa JollaUSA

Personalised recommendations