Protein & Cell

, Volume 2, Issue 9, pp 726–738

Molecular regulation of telomerase activity in aging

  • Craig Nicholls
  • He Li
  • Jian-Qiu Wang
  • Jun-Ping Liu
Review

DOI: 10.1007/s13238-011-1093-3

Cite this article as:
Nicholls, C., Li, H., Wang, JQ. et al. Protein Cell (2011) 2: 726. doi:10.1007/s13238-011-1093-3

Abstract

The process of aging is mitigated by the maintenance and repair of chromosome ends (telomeres), resulting in extended lifespan. This review examines the molecular mechanisms underlying the actions and regulation of the enzyme telomerase reverse transcriptase (TERT), which functions as the primary mechanism of telomere maintenance and regulates cellular life expectancy. Underpinning increased cell proliferation, telomerase is also a key factor in facilitating cancer cell immortalization. The review focuses on aspects of hormonal regulations of telomerase, and the intracellular pathways that converge to regulate telomerase activity with an emphasis on molecular interactions at protein and gene levels. In addition, the basic structure and function of two key telomerase enzyme components—the catalytic subunit TERT and the template RNA (TERC) are discussed briefly.

Keywords

telomerase aging telomerase reverse transcriptase (TERT) 

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Craig Nicholls
    • 1
    • 3
  • He Li
    • 1
  • Jian-Qiu Wang
    • 2
  • Jun-Ping Liu
    • 1
    • 2
    • 3
    • 4
  1. 1.Molecular Signalling LaboratoryMurdoch Childrens Research InstituteParkvilleAustralia
  2. 2.Institute of Aging ResearchHangzhou Normal University School of MedicineHangzhouChina
  3. 3.Department of ImmunologyMonash UniversityMelbourneAustralia
  4. 4.Department of GeneticsUniversity of MelbourneMelbourneAustralia

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