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Dscam mutation leads to hydrocephalus and decreased motor function

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Abstract

The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the nervous system during embryonic development. Previous studies in Drosophila suggest that Dscam plays important roles in neural development including axon branching, dendritic tiling and cell spacing. However, the function of the mammalian DSCAM gene in the formation of the nervous system remains unclear. Here, we show that Dscamdel17 mutant mice exhibit severe hydrocephalus, decreased motor function and impaired motor learning ability. Our data indicate that the mammalian DSCAM gene is critical for the formation of the central nervous system.

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Correspondence to Haihong Ye or Qi Xu or Jane Y. Wu.

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Supplementary material, approximately 27.8 MB.

Supplementary material, approximately 27.8 MB.

Supplementary material, approximately 27.6 MB.

Supplementary material, approximately 27.6 MB.

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Xu, Y., Ye, H., Shen, Y. et al. Dscam mutation leads to hydrocephalus and decreased motor function. Protein Cell 2, 647–655 (2011) doi:10.1007/s13238-011-1072-8

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Keywords

  • Down syndrome cell adhesion molecule
  • motor function
  • motor learning
  • hydrocephalus