Protein & Cell

, Volume 2, Issue 3, pp 237–249

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

  • Sunil K. Verma
  • Trivadi S. Ganesan
  • Uday Kishore
  • Peter J. Parker
Research Article

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

Keywords

RASSF1A Rap1A microtubule vimentin protein-protein interaction 

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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Sunil K. Verma
    • 1
    • 2
    • 3
  • Trivadi S. Ganesan
    • 1
    • 2
  • Uday Kishore
    • 7
  • Peter J. Parker
    • 3
    • 4
  1. 1.Department of Medical Oncology, Medical Sciences DivisionThe University of OxfordOxfordUK
  2. 2.Ovarian Cancer Group, CRUK Molecular Oncology Laboratories, Weatherall Institute of Molecular MedicineJohn Radcliffe HospitalHeadington, OxfordUK
  3. 3.Protein Phosphorylation Laboratory, London Research InstituteCRUK Lincoln’s Inn Fields LaboratoriesLondonUK
  4. 4.Kings College London, The Division of Cancer StudiesSection of Cancer Cell Biology and ImagingLondonUK
  5. 5.Center for Cellular and Molecular BiologyHyderabadIndia
  6. 6.Cancer Institute & Institute of Molecular MedicineAmrita Institute of Medical SciencesKeralaIndia
  7. 7.Center for Infection, Immunity and Disease Mechanisms, Biosciences, School of Health Sciences and Social CareBrunel UniversityUxbridgeWest London, UK

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