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Protein & Cell

, Volume 1, Issue 12, pp 1073–1083 | Cite as

Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway

  • Liming Chen
  • Portia Gloria Loh
  • Haiwei SongEmail author
Review

Abstract

The control of organ size growth is one of the most fundamental aspects of life. In the past two decades, a highly conserved Hippo signaling pathway has been identified as a key molecular mechanism for governing organ size regulation. In the middle of this pathway is a kinase cascade that negatively regulates the downstream component Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ)/Yorkie through phosphorylation. Phosphorylation of YAP/TAZ/Yorkie promotes its cytoplasmic localization, leads to cell apoptosis and restricts organ size overgrowth. When the Hippo pathway is inactivated, YAP/TAZ/Yorkie translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. In this review, we will focus on the structural and functional studies on the downstream transcription factor TEAD and its coactivator YAP.

Keywords

Hippo Yes-associated protein (YAP) transcription enhancer factor (TEAD) Yki phosphorylation crystal structure 

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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Liming Chen
    • 1
  • Portia Gloria Loh
    • 1
  • Haiwei Song
    • 1
    • 2
    • 3
    Email author
  1. 1.Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell BiologyA*STAR (Agency for Science, Technology and Research)SingaporeRepublic of Singapore
  2. 2.Department of Biological SciencesNational University of SingaporeSingaporeRepublic of Singapore
  3. 3.School of Biological SciencesNanyang Technological UniversitySingaporeRepublic of Singapore

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