Protein & Cell

, Volume 1, Issue 11, pp 999–1010 | Cite as

The substrates of Plk1, beyond the functions in mitosis

  • X. Shawn Liu
  • Bing Song
  • Xiaoqi LiuEmail author


Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.


Polo-like kinase 1 phosphorylation substrates 


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© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of BiochemistryPurdue UniversityWest LafayetteUSA
  2. 2.Department of Biological SciencesPurdue UniversityWest LafayetteUSA
  3. 3.Center for Cancer ResearchPurdue UniversityWest LafayetteUSA

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