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Protein & Cell

, Volume 1, Issue 9, pp 802–810 | Cite as

Heteromerization of TRP channel subunits: extending functional diversity

  • Wei Cheng
  • Changsen Sun
  • Jie ZhengEmail author
Review

Abstract

Transient receptor potential (TRP) channels are widely found throughout the animal kingdom. By serving as cellular sensors for a wide spectrum of physical and chemical stimuli, they play crucial physiological roles ranging from sensory transduction to cell cycle modulation. TRP channels are tetrameric protein complexes. While most TRP subunits can form functional homomeric channels, heteromerization of TRP channel subunits of either the same subfamily or different subfamilies has been widely observed. Heteromeric TRP channels exhibit many novel properties compared to their homomeric counterparts, indicating that co-assembly of TRP channel subunits has an important contribution to the diversity of TRP channel functions.

Keywords

co-assembly molecular mechanism diversification nonselective cation channel polymodal receptor multi-subunit protein complex 

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© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Lab of Biomedical Optics, College of Physics and Optoelectronic EngineeringDalian University of TechnologyDalianChina
  2. 2.Department of Physiology and Membrane BiologyUniversity of California School of MedicineDavisUSA

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