Protein & Cell

, Volume 1, Issue 3, pp 275–283 | Cite as

SUMOylation of RIG-I positively regulates the type I interferon signaling

Research Article

Abstract

Retinoic acid-inducible gene-I (RIG-I) functions as an intracellular pattern recognition receptor (PRR) that recognizes the 5’-triphosphate moiety of single-stranded RNA viruses to initiate the innate immune response. Previous studies have shown that Lys63-linked ubiquitylation is required for RIG-I activation and the downstream anti-viral type I interferon (IFN-I) induction. Herein we reported that, RIG-I was also modified by small ubiquitin-like modifier-1 (SUMO-1). Functional analysis showed that RIG-I SUMOylation enhanced IFN-I production through increased ubiquitylation and the interaction with its downstream adaptor molecule Cardif. Our results therefore suggested that SUMOylation might serve as an additional regulatory tier for RIG-I activation and IFN-I signaling.

Keywords

RIG-I SUMOylation type I interferon innate immunity 

Supplementary material

13238_2010_30_MOESM1_ESM.pdf (371 kb)
Supplementary material, approximately 340 KB.

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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Zhiqiang Mi
    • 1
    • 2
  • Jihuan Fu
    • 2
  • Yanbao Xiong
    • 2
  • Hong Tang
    • 2
  1. 1.Center for Molecular Immunology, Institute of MicrobiologyChinese Academy of SciencesBeijingChina
  2. 2.Key Laboratory of Infection and Immunity of Chinese Academy of SciencesInstitute of BiophysicsBeijingChina

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