Macromolecular Research

, Volume 23, Issue 1, pp 53–59 | Cite as

Injectable in situ forming chitosan-based hydrogels for curcumin delivery

  • Titima Songkroh
  • Hongguo Xie
  • Weiting Yu
  • Xiudong Liu
  • Guangwei Sun
  • Xiaoxi Xu
  • Xiaojun MaEmail author


In this paper, a series of injectable in situ forming chitosan-based hydrogels were prepared by chemical crosslinking of chitosan and genipin with the cooperation of ionic bonds between chitosan and sodium salts at room temperature. Four hydrogels (A, B, C, and D) were obtained by mixing chitosan, genipin and a sodium salt of trisodium phosphate (Na3PO4·12H2O), sodium sulfate (Na2SO4), sodium sulfite (Na2SO3), or sodium bicarbonate (NaHCO3) and examined for their characteristics, morphology, and rheological properties. Their cell viability assays exhibited low toxicity and the localized in situ gel formation was detected after subcutaneous injections in rat. Curcumin which possesses many pharmaceutical potentials but has low bioavailability, was chosen as a drug model. In vitro curcumin release profiles exhibit sustained release properties with initial burst release for all hydrogels with about 3 to 6 times higher cumulative release than other gel controls. The results of this study demonstrate that our hydrogels have a potential as local curcumin carriers.


chitosan hydrogel curcumin drug delivery 


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Copyright information

© The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2015

Authors and Affiliations

  • Titima Songkroh
    • 1
    • 2
  • Hongguo Xie
    • 1
  • Weiting Yu
    • 1
  • Xiudong Liu
    • 3
  • Guangwei Sun
    • 1
  • Xiaoxi Xu
    • 1
  • Xiaojun Ma
    • 1
    Email author
  1. 1.Dalian Institute of Chemical Physics (DICP)Chinese Academy of Sciences (CAS)Dalian, LiaoningP. R. China
  2. 2.University of Chinese Academy of Sciences (UCAS)BeijingP. R. China
  3. 3.College of Environment and Chemical EngineeringDalian UniversityDalian, LiaoningP. R. China

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