Macromolecular Research

, Volume 22, Issue 11, pp 1141–1151 | Cite as

Molecular imaging for In vivo tracking of stem cell fate

  • Kyoung Soo Lee
  • Eun Ji Kim
  • Ji Suk Choi
  • Ick Chan Kwon
  • Yong Woo Cho
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Abstract

Stem cells have a potential to dramatically change the common modalities of treatment for many diseases. Despite their rapid transition from animal studies to clinical applications, a number of unanswered questions remain regarding in vivo behaviors of stem cells transplanted into target tissues, including questions about their survival, distribution, migration, differentiation, and tumorigenicity. Recent advances in noninvasive molecular imaging technologies, including optical imaging, magnetic resonance imaging (MRI), radionuclide imaging, and reporter genebased imaging, have gradually elucidated the fundamental behaviors of stem cells via in vivo real time qualitative and quantitative monitoring. Here, we briefly review current imaging techniques for tracking stem cells, with an emphasis on the advantages and drawbacks of each imaging approach, and discuss future prospects for in vivo tracking of stem cells in regenerative medicine.

Keywords

stem cell molecular imaging in vivo tracking regenerative medicine 
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References

  1. (1).
    M. G. Pomper, H. Hammond, X. Yu, Z. Ye, C. A. Foss, D. D. Lin, J. J. Fox, and L. Cheng, Cell. Res., 19, 370 (2009).Google Scholar
  2. (2).
    M. Politis and O. Lindvall, BMC Med., 10, 1741 (2012).Google Scholar
  3. (3).
    S. H. Choi, S. Y. Jung, S. M. Kwon, and S. H. Baek, Circ. J., 76, 1307 (2012).Google Scholar
  4. (4).
    D. E. Kim, D. Schellingerhout, K. Ishii, K. Shah, and R. Weissleder, Stroke, 35, 952 (2004).Google Scholar
  5. (5).
    R. K. Kammili, D. G. Taylor, J. Xia, K. Osuala, K. Thompson, D. R. Menick, and S. N. Ebert, Stem Cells Dev., 19, 1437 (2010).Google Scholar
  6. (6).
    N. Koizumi, T. Inatomi, T. Suzuki, C. Sotozono, and S. Kinoshita, Ophthalmology, 108, 1569 (2001).Google Scholar
  7. (7).
    I. Singec, R. Jandial, A. Crain, G. Nikkhah, and E. Y. Snyder, Annu. Rev. Med., 58, 313 (2007).Google Scholar
  8. (8).
    X. Xie, F. Cao, A. Y. Sheikh, Z. Li, A. J. Connolly, X. Pei, R. K. Li, R. C. Robbins, and J. C. Wu, Cloning Stem Cells, 9, 549 (2007).Google Scholar
  9. (9).
    E. Gu, W. Y. Chen, J. Gu, P. Burridge, and J. C. Wu, Theranostics, 2, 335 (2012).Google Scholar
  10. (10).
    L. Gerrard, D. Zhao, A. J. Clark, and W. Cui, Stem Cells, 23, 124 (2005).Google Scholar
  11. (11).
    Y. Duan, A. Catana, Y. Meng, N. Yamamoto, S. He, S. Gupta, S. S. Gambhir, and M. A. Zern, Stem Cells, 25, 3058 (2007).Google Scholar
  12. (12).
    D. Gordon, C. P. Glover, A. M. Merrison, J. B. Uney, and N. J. Scolding, J. Neuroimmunol., 193, 59 (2008).Google Scholar
  13. (13).
    A. Solanki, J. D. Kim, and K. B. Lee, Nanomedicine, 3, 567 (2008).Google Scholar
  14. (14).
    A. Ruggiero, D. L. J. Thorek, J. Guenoun, G. P. Krestin, and M. R. Bernsen, Eur. Radiol., 22, 189 (2012).Google Scholar
  15. (15).
    M. Hoehn, D. Wiedermann, C. Justicia, P. Ramos-Cabrer, K. Kruttwig, T. Farr, and U. Himmelreich, J. Physiol., 584, 25 (2007).Google Scholar
  16. (16).
    A. M. Smith, H. Duan, A. M. Mohs, and S. Nie, Adv. Drug Deliv. Rev., 60, 1226 (2008).Google Scholar
  17. (17).
    J. Wang, A. Najjar, S. Zhang, B. Rabinovich, J. T. Willerson, J. G. Gelovani, and E. T. Yeh, Circ. Cardiovasc. Imaging, 5, 94 (2012).Google Scholar
  18. (18).
    I. Serganova and R. Blasberg, Nucl. Med. Biol., 32, 763 (2005).Google Scholar
  19. (19).
    J. H. Kang and J. K. Chung, J. Nucl. Med., 49, 164S (2008).Google Scholar
  20. (20).
    M. Rodriguez-Porcel, Curr. Cardiol. Rep., 12, 51 (2010).Google Scholar
  21. (21).
    M. A. Walling, J. A. Novak, and J. R. E. Shepard, Int. J. Mol. Sci., 10, 441 (2009).Google Scholar
  22. (22).
    T. Jamieson, R. Bakhshi, D. Petrova, R. Pocock, M. Imani, and A. M. Seifalian, Biomaterials, 28, 4717 (2007).Google Scholar
  23. (23).
    D. K. Lee and Y.-K. Lee, Macromol. Res., 18, 641 (2010)Google Scholar
  24. (24).
    Y.-K. Lee, S. M. Hong, J. S. Kim, J. H. Im, H. S. Min, E. Subramanyam, K. M. Huh, and S.-W. Park, Macromol. Res., 15, 330 (2007).Google Scholar
  25. (25).
    C. Xu, L. Mu, I. Roes, D. Miranda-Nieves, M. Nahrendorf, J. A. Ankrum, W. Zhao, and J. M. Karp, Nanotechnology, 22, 494001 (2011).Google Scholar
  26. (26).
    A. Bhirde, J. Xie, M. Swierczewska, and X. Chen, Nanoscale, 3, 142 (2011).Google Scholar
  27. (27).
    V. Brunetti, H. Chibli, R. Fiammengo, A. Galeone, M. A. Malvindi, G. Vecchio, R. Cingolani, J. L. Nadeaub, and P. P. Pompa, Nanoscale, 5, 307 (2013).Google Scholar
  28. (28).
    S. J. Soenen, B. B. Manshian, T. Aubert, U. H. J. Demeester, S. C. D. Smedt, Z. Hens, and K. Braeckmans, Chem. Res. Toxicol., 27, 1050 (2014).Google Scholar
  29. (29).
    W. W. Yu, E. Chang, J. C. Falkner, J. Zhang, A. M. Al-Somali, C. M. Sayes, J. Johns, and R. Drezek, J. Am. Chem. Soc., 129, 2871 (2007).Google Scholar
  30. (30).
    B. Dubertret, P. Skourides, D. J. Norris, V. Noireaux, A. H. Brivanlou, and A. Libchaber, Science, 298, 1759 (2002).Google Scholar
  31. (31).
    P. Zhang and H. Han, Colloids and Surfaces A: Physicochem. Eng. Aspects, 402, 72 (2012).Google Scholar
  32. (32).
    D. Gerion, F. Pinaud, S. C. Williams, W. J. Parak, D. Zanchet, S. Weiss, and A. P. Alivisatos, J. Phys. Chem., 105, 8861 (2001).Google Scholar
  33. (33).
    W. Liu, H. S. Choi, J. P. Zimmer, E. Tanaka, J. V. Frangioni, and M. Bawendi, J. Am. Chem. Soc., 129, 14530 (2007).Google Scholar
  34. (34).
    X. Hu and X. Gao, ACS Nano, 4, 6080 (2010).Google Scholar
  35. (35).
    B. J. Muller-Borer, M. C. Collins, P. R. Gunst, W. E. Cascio, and A. P. Kypson, J. Nanobiotechnology, 5, 9 (2007).Google Scholar
  36. (36).
    S. Lin, X. Xie, M. R. Patel, Y. H. Yang, Z. Li, F. Cao, O. Gheysens, Y. Zhang, S. S. Gambhir, J. H. Rao, and J. C. Wu, BMC Biotechnol., 7, 67 (2007).Google Scholar
  37. (37).
    H. Yukawa, Y. Kagami, M. Watanabe, K. Oishi, Y. Miyamoto, Y. Okamoto, M. Tokeshi, N. Kaji, H. Noguchi, K. Ono, M. Sawada, Y. Baba, N. Hamajima, and S. Hayashi, Biomaterials, 31, 4094 (2010).Google Scholar
  38. (38).
    H. Yukawa, M. Watanabe, N. Kaji, Y. Okamoto, M. Tokeshi, Y. Miyamoto, H. Noguchi, Y. Baba, and S. Hayashi, Biomaterials, 33, 2177 (2012).Google Scholar
  39. (39).
    D. L. Kraitchman and J. W. Bulte, Basic Res. Cardiol., 103, 105 (2008).Google Scholar
  40. (40).
    D. L. Kraitchman, W. D. Gilson, and C. H. Lorenz, J. Magn. Reson. Imaging, 27, 299 (2008).Google Scholar
  41. (41).
    W. J. Rogers, C. H. Meyer, and C. M. Kramer, Nat. Clin. Pract. Cardiovasc. Med., 3, 554 (2006).Google Scholar
  42. (42).
    P. Debbage and W. Jaschke, Histochem. Cell Biol., 130, 845 (2008).Google Scholar
  43. (43).
    C. Rümenapp, B. Gleich, and A. Haase, Pharm. Res., 29, 1165 (2012).Google Scholar
  44. (44).
    D. Y. Lee, Macromol. Res., 19, 843 (2011).Google Scholar
  45. (45).
    R. Schäfer, R. Kehlbach, J. Wiskirchen, R. Bantleon, J. Pintaske, B. R. Brehm, A. Gerber, H. Wolburg, C. D. Claussen, and H. Northoff, Radiology, 244, 514 (2007).Google Scholar
  46. (46).
    A. B. Mathiasen, L. Hansen, T. Friis, C. Thomsen, K. Bhakoo, and J. Kastrup, Stem Cells Int., 18, 362 (2013).Google Scholar
  47. (47).
    J. B. Qin, K. A. Li, X. X. Li, Q. S. Xie, J. Y. Lin, K. C. Ye, M. E. Jiang, G. X. Zhang, and X. W. Lu, Int. J. Nanomedicine, 7, 5191 (2012).Google Scholar
  48. (48).
    A. S. Arbab, S. D. Pandit, S. A. Anderson, G. T. Yocum, M. Bur, V. Frenkel, H. M. Khuu, E. J. Read, and J. A. Frank, Stem Cells, 24, 671 (2006).Google Scholar
  49. (49).
    J. Zhu, L. Zhou, and F. XingWu, N. Engl. J. Med., 355, 2376 (2006).Google Scholar
  50. (50).
    A. Nedopil, C. Klenk, C. Kim, S. Liu, M. Wendland, D. Golovko, T. Schuster, B. Sennino, D. M. McDonald, and H. E. Daldrup-Link, Invest. Radiol., 45, 634 (2010).Google Scholar
  51. (51).
    T. Tallheden, U. Nannmark, M. Lorentzon, O. Rakotonirainy, B. Soussi, F. Waagstein, A. Jeppsson, E. Sjogren-Jansson, A. Lindahl, and E. Omerovic, Life Sci., 79, 999 (2006).Google Scholar
  52. (52).
    R. Guzman, N. Uchida, T. M. Bliss, D. He, K. K. Christopherson, D. Stellwagen, A. Capela, J. Greve, R. C. Malenka, M. E. Moseley, T. D. Palmer, and G. K. Steinberg, Proc. Natl. Acad. Sci. U.S.A., 104, 10211 (2007).Google Scholar
  53. (53).
    M. Di Marco, C. Sadun, M. Port, I. Guilbert, P. Couvreur, and C. Dubernet, Int. J. Nanomedicine, 2, 609 (2008).Google Scholar
  54. (54).
    J. Terrovitis, M. Stuber, A. Youssef, S. Preece, M. Leppo, E. Kizana, M. Schar, G. Gerstenblith, R. G. Weiss, E. Marban, and M. R. Abraham, Circulation, 117, 1555 (2008).Google Scholar
  55. (55).
    C. Corot, P. Robert, J. M. Idée, and M. Port, Adv. Drug Deliv. Rev., 58, 1471 (2006).Google Scholar
  56. (56).
    D. L. J. Thorek, A. K. Chen, J. Czupryna, and A. Tsourkas, Ann. Biomed. Eng., 34, 23 (2006).Google Scholar
  57. (57).
    G. Liu, Z. Wang, J. Lu, C. Xia, F. Gao, Q. Gong, B. Song, X. Zhao, X. Shuai, X. Chen, H. Ai, and Z. Gu, Biomaterials, 32, 528 (2011).Google Scholar
  58. (58).
    L. Kostura, D. L. Kraitchman, A. M. Mackay, M. F. Pittenger, and J. W. M. Bulte, NMR Biomed., 17, 516 (2004).Google Scholar
  59. (59).
    R. Schäfer, R. Kehlbach, M. Müller, R. Bantleon, T. Kluba, M. Ayturan, G. Siegel, H. Wolburg, H. Northoff, K. Dietz, C. D. Claussen, and J. Wiskirchen, Cytotherapy, 11, 68 (2009).Google Scholar
  60. (60).
    A. S. Arbab, G. T. Yocum, H. Kalish, E. K. Jordan, S. A. Anderson, A. Y. Khakoo, E. J. Read, and J. A. Frank, Blood, 104, 1217 (2004).Google Scholar
  61. (61).
    A. T. Chan and M. R. Abraham, J. Nucl. Cardiol., 19, 118 (2012).Google Scholar
  62. (62).
    M. M. Welling, M. Duijvestein, A. Signore, and L. V. D. Weerd, J. Cell. Physiol., 226, 1444 (2010).Google Scholar
  63. (63).
    A. Rahmim and H. Zaidi, Nucl. Med. Commun., 29, 193 (2008).Google Scholar
  64. (64).
    R. L. Wahl, J. M. Herman, and E. Ford, Semin. Radiat. Oncol., 21, 88 (2011).Google Scholar
  65. (65).
    L. Zimmer and A. Luxen, Neuroimage, 61, 363 (2012).Google Scholar
  66. (66).
    C. Müller, Molecules, 18, 5005 (2013).Google Scholar
  67. (67).
    E. Wolfs, T. Struys, T. Notelaers, S. J. Roberts, A. Sohni, G. Bormans, K. Van Laere, F. P. Luyten, O. Gheysens, I. Lambrichts, C. M. Verfaillie, and C. M. Deroose, J. Nucl. Med., 54, 447 (2013).Google Scholar
  68. (68).
    W. J. Kang, H.-J. Kang, H.-S. Kim, J.-K. Chung, M. C. Lee, and D. S. Lee, J. Nucl. Med., 47, 1295 (2006).Google Scholar
  69. (69).
    E. Elhami, A. L. Goertzen, B. Xiang, J. Deng, C. Stillwell, S. Mzengeza, R. C. Arora, D. Freed, and G. Tian, Eur. J. Nucl. Med. Mol. Imaging, 38, 1323 (2011).Google Scholar
  70. (70).
    B. Ma, K. D. Hankenson, J. E. Dennis, A. I. Caplan, S. A. Goldstein, and M. R. Kilbourn, Nucl. Med. Biol., 32, 701 (2005).Google Scholar
  71. (71).
    F. Cao, Z. Li, A. Lee, Z. Liu, K. Chen, H. Wang, W. Cai, X. Chen, and J. C. Wu, Cancer Res., 69, 2709 (2009).Google Scholar
  72. (72).
    S. Chakraborty and S. Liu, Curr. Top. Med. Chem., 10, 1113 (2010).Google Scholar
  73. (73).
    A. Aicher, W. Brenner, M. Zuhayra, C. Badorff, S. Massoudi, B. Assmus, T. Eckey, E. Henze, A. M. Zeiher, and S. Dimmeler, Circulation, 107, 2134 (2003).Google Scholar
  74. (74).
    W. Brenner, A. Aicher, T. Eckey, S. Massoudi, M. Zuhayra, U. Koehl, C. Heeschen, W. U. Kampen, A. M. Zeiher, S. Dimmeler, and E. Henze, J. Nucl. Med., 45, 512 (2004).Google Scholar
  75. (75).
    K. J. Blackwood, B. Lewden, R. G. Wells, J. Sykes, R. Z. Stodilka, G. Wisenberg, and F. S. Prato, J. Nucl. Med., 50, 927 (2009).Google Scholar
  76. (76).
    F. J. Gildehaus, F. Haasters, I. Drosse, E. Wagner, C. Zach, W. Mutschler, P. Cumming, P. Bartenstein, and M. Schieker, Mol. Imaging Biol., 13, 1204 (2011).Google Scholar
  77. (77).
    O. Buckley, S. O’Keeffe, T. Geoghegan, I. D. Lyburn, P. L. Munk, D. Worsley, and W. C. Torreggiani, Nucl. Med. Commun., 28, 521 (2007).Google Scholar
  78. (78).
    P. Becerra, M. A. V. Vazquez, J. Dudhia, A. R. Fiske-Jackson, F. Neves, N. G. Hartman, and R. K. W. Smith, J. Orthop. Res., 31, 1096 (2013).Google Scholar
  79. (79).
    M. Inubushi and N. Tamaki, Eur. J. Nucl. Med. Mol. Imaging, 34, S27 (2007).Google Scholar
  80. (80).
    P. D. Acton and R. Zhou, Q. J. Nucl. Med. Mol. Imaging, 49, 349 (2005).Google Scholar
  81. (81).
    Y. Fu, D. Kedziorek, and D. L. Kraitchman, J. Cardiovasc. Transl. Res., 3, 24 (2010).Google Scholar
  82. (82).
    B. P. Cormack, R. H. Valdivia, and S. Falkow, Gene, 173, 33 (1996).Google Scholar
  83. (83).
    C. Andressen, E. Stöcker, F. J. Klinz, N. Lenka, J. Hescheler, B. Fleischmann, S. Arnhold, and K. Addicks, Stem Cells, 19, 419 (2001).Google Scholar
  84. (84).
    M. Keyaerts, V. Caveliers, and T. Lahoutte, Trends Mol. Med., 18, 164 (2012).Google Scholar
  85. (85).
    J. Brogan, F. Li, W. Li, Z. He, Q. Huang, and C. Y. Li, Radiat. Res., 177, 508 (2012).Google Scholar
  86. (86).
    J. J. Min, Y. Ahn, S. Moon, Y. S. Kim, J. E. Park, S. M. Kim, U. N. Le, J. C. Wu, S. Y. Joo, M. H. Hong, D. H. Yang, M. H. Jeong, C. H. Song, Y. H. Jeong, K. Y. Yoo, K. S. Kang, and H. S. Bom, Ann. Nucl. Med., 20, 165 (2006).Google Scholar
  87. (87).
    S. W. Lee, S. H. Lee, and S. Biswal, Theranostics, 2, 403 (2012).Google Scholar
  88. (88).
    A. A. Gilad, P. T. W. Jr, P. C. M. Zijl, and J. W. M. Bulte, NMR Biomed., 20, 275 (2007).Google Scholar
  89. (89).
    A. A. Gilad, K. Ziv, M. T. McMahon, P. C. van Zijl, M. Neeman, and J. W. Bulte, J. Nucl. Med., 49, 1905 (2008).Google Scholar
  90. (90).
    N. E. Bengtsson, G. Brown, E. W. Scott, and G. A. Walter, Magn. Reson. Med., 63, 745 (2010).Google Scholar
  91. (91).
    J. Chung, K. Kee, J. K. Barral, R. Dash, H. Kosuge, X. Wang, I. Weissman, R. C. Robbins, D. Nishimura, T. Quertermous, R. A. Reijo-Pera, and P. C. Yang, Magn. Reson. Med., 66, 1374 (2011).Google Scholar
  92. (92).
    M. Campan, V. Lionetti, G. D. Aquaro, F. Forini, M. Matteucci, L. Vannucci, F. Chiuppesi, C. D. Cristofano, M. Faggioni, M. Maioli, L. Barile, E. Messina, M. Lombardi, A. Pucci, M. Pistello, and F. A. Recchia, Am. J. Physiol. Heart. Circ. Physiol., 300, H2238 (2011).Google Scholar
  93. (93).
    M. M. Alauddin and J. G. Gelovani, Curr. Top. Med. Chem., 10, 1617 (2010).Google Scholar
  94. (94).
    P. Brader, I. Serganova, and R. G. Blasberg, J. Nucl. Med., 54, 167 (2013).Google Scholar
  95. (95).
    T. Kogai and G. A. Brent, Pharmacol. Ther., 135, 355 (2012).Google Scholar
  96. (96).
    J. Terrovitis, K. F. Kwok, R. Lautamäki, J. M. Engles, A. S. Barth, E. Kizana, J. Miake, M. K. Leppo, J. Fox, J. Seidel, M. Pomper, R. L. Wahl, B. Tsui, F. B. E. Marbán, and M. R. Abraham, J. Am. Coll. Cardiol., 52, 1652 (2008).Google Scholar
  97. (97).
    R. M. Dwyer, J. Ryan, R. J. Havelin, J. C. Morris, B. W. Miller, Z. Liu, R. Flavin, C. O'Flatharta, M. J. Foley, H. H. Barrett, J. M. Murphy, F. P. Barry, T. O’Brien, and M. J. Kerin, Stem Cells, 29, 1149 (2011).Google Scholar
  98. (98).
    M. R. Bernsen, A. D. Moelker, P. A. Wielopolski, S. T. van Tiel, and G. P. Krestin, Eur. Radiol., 20, 255 (2010).Google Scholar
  99. (99).
    M. Doubrovin, I. Serganova, P. Mayer-Kuckuk, V. Ponomarev, and R. G. Blasberg, Bioconjug. Chem., 15, 1376 (2004).Google Scholar
  100. (100).
    X. Bai, Y. Yan, M. Coleman, G. Wu, B. Rabinovich, M. Seidensticker, and E. Alt, Mol. Imaging Biol., 13, 633 (2011).Google Scholar
  101. (101).
    H. Wang, F. Cao, A. De, Y. Cao, C. Contag, S. S. Gambhir, J. C. Wu, and X. Chen, Stem Cells, 27, 1548 (2009).Google Scholar
  102. (102).
    M. Vilalta, C. Jorgensen, I. R. Dégano, Y. Chernajovsky, D. Gould, D. Noël, J. A. Andrades, J. Becerra, N. Rubio, and J. Blanco, Biomaterials, 30, 4986 (2009).Google Scholar
  103. (103).
    A. S. Lee, C. Tang, F. Cao, X. Xie, K. Bogt, A. Hwang, A. J. Connolly, R. C. Robbins, and J. C. Wu, Cell Cycle, 8, 2608 (2009).Google Scholar
  104. (104).
    F. Cao, S. Lin, X. Xie, P. Ray, M. Patel, X. Zhang, M. Drukker, S. J. Dylla, A. J. Connolly, X. Chen, I. L. Weissman, S. S. Gambhir, and J. C. Wu, Circulation, 113, 1005 (2006).Google Scholar
  105. (105).
    F. Cao, M. Drukker, S. Lin, A. Y. Sheikh, X. Xie, Z. Li, A. J. Connolly, I. L. Weissman, and J. C. Wu, Cloning Stem Cells, 9, 107 (2007).Google Scholar
  106. (106).
    M. Gyöngyösi, J. Blanco, T. Marian, L. Trón, Ö. Petneházy, Z. Petrasi, R. Hemetsberger, J. Rodriguez, G. Font, I. J. Pavo, I. Kertész, L. Balkay, N. Pavo, A. Posa, M. Emri, L. Galuska, D. L. Kraitchman, J. Wojta, K. Huber, and D. Glogar, Circ. Cardiovasc. Imaging, 1, 94 (2008).Google Scholar
  107. (107).
    F. Wang, J. E. Dennis, A. Awadallah, L. A. Solchaga, J. Molter, Y. Kuang, N. Salem, Y. Lin, H. Tian, J. A. Kolthammer, Y. Kim, Z. B. Love, S. L. Gerson, and Z. Lee, Physiol. Genomics, 37, 23 (2009).Google Scholar
  108. (108).
    J. Rao, A. Dragulescu-Andrasi, and H. Yao, Curr. Opin. Biotechnol., 18, 17 (2007).Google Scholar
  109. (109).
    E. Lacivita, M. Leopoldo, F. Berardi, N. A. Colabufo, and R. Perrone, Curr. Med. Chem., 19, 4731 (2012).Google Scholar
  110. (110).
    S. Lee, K. Park, K. Kim, K. Choi, and I. C. Kwon, chem. Commun. (Camb.), 38, 4250 (2008).Google Scholar
  111. (111).
    X. Wang, C. Wang, L. Cheng, S.-T. Lee, and Z. Liu, J. Am. Chem. Soc., 134, 7414 (2012).Google Scholar
  112. (112).
    J. Y. Yhee, S. A. Kim, H. Koo, S. Son, J. H. Ryu, I.-C. Youn, K. Choi, I. C. Kwon, and K. Kim, Theranostics, 2, 179 (2012).Google Scholar
  113. (113).
    K. Kim, M. Lee, H. Park, J.-H. Kim, S. Kim, H. Chung, K. Choi, I.-S. Kim, B. L. Seong, and I. C. Kwon, J. Am. Chem. Soc., 128, 3490 (2006).Google Scholar
  114. (114).
    D. E. Lee, J. H. Na, S. Lee, C. M. Kang, H. N. Kim, S. J. Han, H. Kim, Y. S. Choe, K. H. Jung, K. C. Lee, K. Choi, I. C. Kwon, S. Y. Jeong, K. H. Lee, and K. Kim, Mol. Pharm., 10, 2190 (2013).Google Scholar
  115. (115).
    E. S. Olson, T. Jiang, T. A. Aguilera, Q. T. Nguyen, L. G. Ellies, M. Scadeng, and R. Y. Tsien, Proc. Natl. Acad. Sci. U S A, 107, 4311 (2010).Google Scholar
  116. (116).
    D.-E. Lee, A. Y. Kim, G. Saravanakumar, H. Koo, I. C. Kwon, K. Choi, J. H. Park, and K. Kim, Macromol. Res., 19, 861 (2011).Google Scholar
  117. (117).
    H. J. Cho, H. Y. Yoon, H. Koo, S. H. Ko, J. S. Shim, J. H. Cho, J. H. Park, K. Kim, I. C. Kwon, and D.-D. Kim, J. Control. Release, 162, 111 (2012).Google Scholar
  118. (118).
    I. C. Sun, D. K. Eun, H. Koo, C. Y. Ko, H. S. Kim, D. K. Yi, K. Choi, I. C. Kwon, K. Kim, and C. H. Ahn, Angew. Chem. Int. Ed. Engl., 50, 9348 (2012).Google Scholar
  119. (119).
    H. Gul, W. Lu, P. Xu, J. Xing, and J. Chen, Nanotechnology, 21, 155101 (2010).Google Scholar
  120. (120).
    D. A. Heller, S. Baik, T. E. Eurell, and M. S. Strano, Adv. Mater., 17, 2793 (2005).Google Scholar
  121. (121).
    T. J. Wu, Y. K. Tzeng, W. W. Chang, C. A. Cheng, Y. Kuo, C. H. Chien, H. C. Chang, and J. Yu, Nat. Nanotechnol., 8, 682 (2013).Google Scholar

Copyright information

© The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2014

Authors and Affiliations

  • Kyoung Soo Lee
    • 1
  • Eun Ji Kim
    • 1
  • Ji Suk Choi
    • 1
  • Ick Chan Kwon
    • 2
  • Yong Woo Cho
    • 1
    • 2
  1. 1.Department of Chemical EngineeringHanyang UniversityAnsan, GyeonggiKorea
  2. 2.Center for Theragnosis, Biomedical Research InstituteKorea Institute of Science and Technology (KIST)SeoulKorea

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