Macromolecular Research

, Volume 20, Issue 9, pp 960–967 | Cite as

Polymeric tube-shaped devices with controlled geometry for programmed drug delivery

  • Min Park
  • Chun Gwon Park
  • Seung Ho Lee
  • Ji Eun Lee
  • Eunbit Cho
  • Mark R. Prausnitz
  • Young Bin Choy
Article
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Revised:
Accepted:

Abstract

We developed a modular tube-shaped device as a proof of principle to enable the programmed release of encapsulated molecules for controlled drug delivery. Each drug-delivery tube module was prepared by assembling two separate silicone tubes in a series, one filled with a model compound (sodium fluorescein) and the other with a diffusional barrier material (polyethylene oxide, PEO). We varied the length of the PEO-filled tubes to control the release from the drug-delivery tube devices. The onset times and periods of drug release increased with the length of the PEO tube. To program the drug release, therefore, we prepared devices with combinations of drug-delivery tube modules with different lengths of PEO-filled tubes. Using PEO-filled tubes with very different lengths achieved a pulsatile drug release while a continuous drug release was realized by using PEO-filled tubes with small differences in length. We concluded that the modular combination of drug-delivery tubes, each composed of a diffusionbarrier tube of different length, demonstrates good potential for applications in programmed drug delivery.

Keywords

continuous drug release drug-delivery tube polyethylene oxide (PEO) programmed drug delivery pulsatile drug silicone 
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Copyright information

© The Polymer Society of Korea and Springer Netherlands 2012

Authors and Affiliations

  • Min Park
    • 1
  • Chun Gwon Park
    • 1
  • Seung Ho Lee
    • 1
  • Ji Eun Lee
    • 1
  • Eunbit Cho
    • 2
  • Mark R. Prausnitz
    • 3
  • Young Bin Choy
    • 1
    • 2
    • 4
  1. 1.Interdisciplinary Program in Bioengineering, College of EngineeringSeoul National UniversitySeoulKorea
  2. 2.Department of Biomedical Engineering, College of MedicineSeoul National UniversitySeoulKorea
  3. 3.School of Chemical and Biomolecular EngineeringGeorgia Institute of TechnologyAtlantaUSA
  4. 4.Institute of Medical & Biological Engineering, Medical Research CenterSeoul National UniversitySeoulKorea

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