Fungal Diversity

, Volume 55, Issue 1, pp 1–35 | Cite as

Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action

  • Dilani D. De Silva
  • Sylvie Rapior
  • Françoise Fons
  • Ali H. Bahkali
  • Kevin D. Hyde
Original Paper


Medicinal mushrooms have been valued as natural sources of bioactive compounds since times immemorial and have been recognized as potential immunomodulating and anti-cancer agents. Their consumption has consistently been shown to have beneficial effects on human health. Cancer is a generic term for several types of diseases that can be chronic and are responsible for a large number of deaths worldwide. Although there has been considerable progress in modern cancer therapy research, difficulties in understanding the molecular behavior of various types of cancers and the numerous side effects experienced by patients from treatments means that this whole subject area is still problematic. Thus, biological immunotherapy using natural bioactive compounds as supportive treatments in conventional cancer therapies has become in vogue. Bioactive metabolites isolated from medicinal mushrooms have shown potential successes in cancer treatment as biological immunotherapeutic agents that stimulate the immune system against cancer cells. They also act as an effective source of anti-cancer agents, capable of interfering with cellular signal transduction pathways linked to cancer development and progression. In this review we compile available data on the characteristics of medicinal mushrooms that appear to be particularly effective as biological immunotherapeutic agents. Major consideration is given to biological constituents and the putative mechanisms of action by which bioactive compounds act on the human body. Consideration is also given to the benefits that have been claimed for the use of mushrooms in treating cancer and the future prospects of using medicinal mushrooms as potent supportive candidate bioagents for treatment of cancers is discussed.


Medicinal mushrooms Cancer Anti-cancer Immunomodulation Bioactive metabolites 



This study was supported by a grant of the French-Thai cooperation PHC SIAM 2011 (project 25587RA). The authors are grateful to Professor Alain Fruchier (ENSCM, Montpellier, France) for his helpful comments and corrections relating to chemistry. The Global Research Network for Fungal Research and King Saud University are also thanked for support.


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Copyright information

© The Mushroom Research Foundation 2012

Authors and Affiliations

  • Dilani D. De Silva
    • 1
    • 2
    • 3
  • Sylvie Rapior
    • 4
  • Françoise Fons
    • 4
  • Ali H. Bahkali
    • 5
  • Kevin D. Hyde
    • 1
    • 2
    • 5
  1. 1.Institute of Excellence in Fungal ResearchMae Fah Luang UniversityChiang RaiThailand
  2. 2.School of ScienceMae Fah Luang UniversityChiang RaiThailand
  3. 3.Department of Botany, Faculty of ScienceUniversity of PeradeniyaPeradeniyaSri Lanka
  4. 4.Faculty of PharmacyUniversity Montpellier 1, UMR 5175 CEFEMontpellier Cedex 5France
  5. 5.Botany and Microbiology Department, College of ScienceKing Saud UniversityRiyadhSaudi Arabia

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