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Pregnancy and Its Successful Outcome in a Patient with Multiple Myeloma

  • Akanksha GargEmail author
  • Monika Aggarwal
  • Rajesh Kashyap
Case Report
  • 6 Downloads

Abstract

Multiple myeloma is a B-cell neoplastic disorder and represents 1% of all cancers and 13% of hematological malignancies. It is predominantly a disease of elderly, and less than 3% of all cases are below the age of 40 years. We present the case of a 29-year-old lady with multiple myeloma who had spontaneous conception during maintenance therapy and subsequently a successful pregnancy outcome. She gave birth to a healthy female infant through normal vaginal delivery and subsequently could remain off therapy for 5 years. Since the patient had a history of abortions and stillbirth, it was a precious pregnancy and we could successfully salvage both the mother and the baby. Young female patients of myeloma who are in remission can be encouraged to start a family during their reproductive years with the support of a comprehensive care team of hematologists/oncologists and obstetricians.

Keywords

Myeloma Pregnancy Bad obstetric history 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that he has no conflict of interest.

Informed Consent

Informed consent was taken for publication of this case report from patient.

References

  1. 1.
    Caers J, Vandebroek I, De Raeve H, et al. Multiple myeloma—an update on diagnosis and treatment. Eur J Hematol. 2008;81:329–43.Google Scholar
  2. 2.
    Khot AS, Prince HM, Harrison SJ, et al. Myeloma and pregnancy: strange bedfellows? Leuk Lymphoma. 2014;55:966–8.CrossRefGoogle Scholar
  3. 3.
    Lergier JE, Jimenez E, Maldonado N, Veray F. Normal pregnancy in multiple myeloma treated with cyclophosphamide. Cancer. 1974;34:1018–22.CrossRefGoogle Scholar
  4. 4.
    Brisou G, Bouafia-Sauvy F, Karlin L, et al. Pregnancy and multiple myeloma are not antinomic. Leuk Lymphoma. 2013;54:2738–41.CrossRefGoogle Scholar
  5. 5.
    Jurczyszyn A, Olszewska-Szopa M, Vesole AS, et al. Multiple Myeloma in pregnancy—a review of the literature and a case series. Clin Lymphoma Myeloma Leuk. 2016;16:e39–45.CrossRefGoogle Scholar
  6. 6.
    Chellakooty M, Vangsgaard K, Larsen T, et al. A longitudinal study of intrauterine growth and the placental growth hormone (GH)- insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth. J Clin Endocrinol Metabol. 2004;89:384–91.CrossRefGoogle Scholar
  7. 7.
    Aviles A, Neri N. Multiple myeloma and pregnancy. Am J Hematol. 2011;86:81–2.CrossRefGoogle Scholar
  8. 8.
    Sakata H, Karamitsos J, Kundaria B, DiSaia PJ. Case report of interferon alfa therapy for MM during pregnancy. Am J Obstet Gynaecol. 1995;172:217–9.CrossRefGoogle Scholar
  9. 9.
    Rosner F, Soong BC, Krim M, Miller SP. Normal pregnancy in a patient with MM. Obs Gynaecol. 1968;31:811–20.Google Scholar
  10. 10.
    Kosova LA, Schwartz SO. MM and normal pregnancy. Report of a case. Blood. 1966;28:102–11.CrossRefGoogle Scholar
  11. 11.
    Pereg D, Koren G, Lishner M. Cancer in pregnancy: gaps, challenges and solutions. Cancer Treat Rev. 2008;34:302–12.CrossRefGoogle Scholar
  12. 12.
    Semra P. Management of hematopoietic neoplasias during pregnancy. Crit Rev Onclo Hematol. 2016;104:52–64.CrossRefGoogle Scholar

Copyright information

© Federation of Obstetric & Gynecological Societies of India 2020

Authors and Affiliations

  1. 1.Department of HematologySanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia
  2. 2.Department of Obstetrics and GynaecologyLady Hardinge Medical CollegeNew DelhiIndia

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