Long-Term Outcome of Fetuses with Soft Marker and Without Genetic or Structural Abnormality

  • Migraci Tosun
  • Emel Kurtoglu OzdesEmail author
  • Erdal Malatyalioglu
  • Erhan Yavuz
  • Handan Celik
  • Fatma Devran Bildircin
  • Kubilay Canga
  • Arif Kokcu
  • Gonul Ogur
Original Article



To determine long-term outcome of infants with isolated or multiple soft markers but no structural or chromosomal abnormalities.


A retrospective study of 78 pregnant women who were referred for amniocentesis and found to have soft markers including echogenic intracardiac focus/foci (EIF), echogenic bowel (EB), unilateral or bilateral choroid plexus cysts, (UCPCs or BCPCs) mild pyelectasis and single umbilical artery but no structural anomalies and outcomes of the liveborns with a 4- to 9-year follow-up was conducted.


Among 28 fetuses with EIF, allergic asthma and epilepsy were diagnosed in two liveborns. We followed up nine pregnancies with EB, epilepsy was present in one case. Allergic asthma was detected in both UCPCs and BCPCs, whereas epilepsy and attention-deficit/hyperactivity disorder (ADHD) were diagnosed in two liveborns with BCPCs. Twelve liveborns with multiple soft markers were evaluated; no pathology was detected in most of them except one case of allergic asthma, one case of hearing impairment and one case of ADHD.


This study shows longer-term favorable outcomes of the liveborns with isolated or multiple soft markers without any aneuploidy and may provide insight into this debated point.


Fetus Ultrasonography Soft marker Follow-up Long-term Outcome 



The present study was conducted on 78 pregnant women with 15–22 weeks of singleton gestation who were referred to Ondokuz Mayis University Fetal Medicine Unit between January 2005 and January 2010 for amniocentesis and found to have isolated or multiple soft markers but no structural anomalies at the same time of procedure; and outcomes of these pregnancies and the liveborns.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Statements

The study was approved by Ondokuz Mayis University Ethics Committee, and the patient records/information was anonymized and de-identified prior to analysis.

Informed Consent

Informed consent was obtained from each individual participant.


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Copyright information

© Federation of Obstetric & Gynecological Societies of India 2018

Authors and Affiliations

  1. 1.Department of Obstetrics and Gynecology, Faculty of MedicineOndokuz Mayis UniversitySamsunTurkey
  2. 2.Avrasya Medi-tech HospitalOrduTurkey
  3. 3.Department of Medical Genetics, Faculty of MedicineOndokuz Mayis UniversitySamsunTurkey

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