Advertisement

Study of Effect of Vitamin D Supplementation on the Clinical, Hormonal and Metabolic Profile of the PCOS Women

  • Taru Gupta
  • Mukta Rawat
  • Nupur Gupta
  • Sarika Arora
Original Article

Abstract

Introduction

Insulin resistance is one of the most common features of polycystic ovary syndrome, and some studies suggest that vitamin D deficiency may have role in insulin resistance.

Objective

To study the effect of vitamin D supplementation on the clinical, hormonal and metabolic profile of the PCOS women.

Study Design

Randomized, placebo-controlled, interventional, double-blind study.

Materials and Methods

PCOS women were evaluated and enrolled after considering inclusion and exclusion criteria. They were randomized by block randomization with sealed envelope system done in two groups. In the study group (n = 25), patients were supplemented with vitamin D 60,000 IU weekly for 12 weeks, whereas control group (n = 25) was given placebo weekly for the same period. Both the groups were compared pre- and post-supplementation for variables like clinical profile, biochemical profile and metabolic profile. Statistical analysis was performed by the SPSS program for Windows, version 10.1 (SPSS, Chicago, IL).

Result

In the study (n = 50), PCOS patients were enrolled; 34 patients (68%) were vitamin D deficient (≤20 ng/ml) out of which 10 patients (29%) were severely deficient (<10 ng/ml). Twelve patients (24%) were vitamin D insufficient showing high prevalence of vitamin D deficiency in the PCOS women. The difference in mean serum fasting glucose pre- and post-supplementation of vitamin D in study group was found to be statistically significant with p value of 0.041. There was significant difference seen in insulin resistance (IR) (2.38 ± 4.88–1.00 ± 0.58, p = 0.003), serum fasting insulin (10.34 ± 20.00–5.00 ± 3.25, p = 0.021), and increase in insulin sensitivity determined by QUICKI (0.37 ± 0.04–0.394 ± 0.009, p = 0.001) after supplementation with vitamin D.

Conclusion

The study concluded that there was a beneficial effect of vitamin D supplementation on ovulatory dysfunctions and blood pressure. Post-supplementation, there were decrease in insulin resistance and increase in insulin sensitivity. In the study decreased serum fasting insulin level and fasting blood sugar after vitamin D supplementation suggest underlying role of vitamin D in glucose homeostasis.

Keywords

Vitamin D PCOS Insulin resistance Glucose homeostasis 

Notes

Funding

This study was not funded by any outsource.

Compliance with Ethical Statement

Conflict of interest

All authors declare that they have no conflict of interest.

Research Involving Human Participants

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Tai K, Need AG, Horowitz M, Chapman IM. Vitamin D glucose, insulin, and insulin sensitivity. Nutrition. 2008;24:279–85.CrossRefPubMedGoogle Scholar
  2. 2.
    Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TR, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol. 2009;161:575–82.CrossRefPubMedGoogle Scholar
  3. 3.
    Yildizhan R, Kurdoglo M, Adali E, Kolusari A, Yildizhan B, Sahin HG, et al. Serum 25-hydroxyvitamin D concentrations in obese and non obese women with polycystic ovary syndrome. Arch Gynaecol Obstet. 2009;280:559–63.CrossRefGoogle Scholar
  4. 4.
    Khan NR, Shah J, Stetter CM, Lott Mary EJ, Kunselman D. High dose vitamin D supplementation and measures of insulin sensitivity in PCOS:a randomized controlled pilot trial. Fertil Steril. 2014;101(6):1740–6.CrossRefGoogle Scholar
  5. 5.
    Li HWR, Brereton RE, Anderson RA, et al. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metab, Clin Exp. 2010;60:1475–81.CrossRefGoogle Scholar
  6. 6.
    Ardabili HR, Gargari BP, Farzadi L. Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency. Nutr Res. 2012;2012(32):195–201. doi: 10.1016/j.nutres.02.001.CrossRefGoogle Scholar
  7. 7.
    Lagunova Z, Porojnicu AC, Lindberg F, et al. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res. 2009;29:3713–20.PubMedGoogle Scholar
  8. 8.
    Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in PCOS women—a pilot study. J Endocrinol Invest. 2011;34:757–63.PubMedGoogle Scholar
  9. 9.
    Forman JP, Curhan GC, Taylor EN. Plasma 25- hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension. 2008;52:828–32.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Pilz S, Tomaschitz A, Ritz E, Pieber TR. Vitamin D status and arterial hypertension: a systemic review. Nat Rev Cardiol. 2009;6:621–30.CrossRefPubMedGoogle Scholar
  11. 11.
    Raishidi B, Haghollahi F, Shariat M, et al. The effects of calcium-vitamin D and Metformin on polycystic ovary syndrome; a pilot study. Taiwan J Obstetr Gynecol. 2009;48:142–7.CrossRefGoogle Scholar
  12. 12.
    Kotsa K, Yavropoulou MP, Anastasiou O, Yovos JG. Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome. Fertil Steril. 2009;92:1053–8.CrossRefPubMedGoogle Scholar
  13. 13.
    Moscogiuri G, Policola C, Prioletta A et al. Low levels of 25(OH)D and insulin resistance: 2 unrelated features or a cause effect in PCOS? Clin Nutr 2012; PMID:22260937 [epub ahead of print].Google Scholar
  14. 14.
    Seglimoglu H, Duran C, Kiyici S, Ersoy C, Guclu M, Ozkaya G. The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome. J Endocrinol Invest. 2010;33:234–8.CrossRefGoogle Scholar
  15. 15.
    Wehr E, Trummer O, Giuliani A, et al. Vitamin D—associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol. 2011;164:741–9.CrossRefPubMedGoogle Scholar
  16. 16.
    Alvarez JA, Ashraf A. Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol. 2010; 351385. doi:1155/2010/351385.Google Scholar

Copyright information

© Federation of Obstetric & Gynecological Societies of India 2017

Authors and Affiliations

  • Taru Gupta
    • 1
  • Mukta Rawat
    • 1
  • Nupur Gupta
    • 1
  • Sarika Arora
    • 2
  1. 1.Department of Obstetrics and GynaecologyESI PGIMSRNew DelhiIndia
  2. 2.Department of BiochemistryESI PGIMSRNew DelhiIndia

Personalised recommendations