Advertisement

Role of 17 α Hydroxy Progesterone Caproate (17OHPC) in the Prevention of Preterm Labor

  • Asma Nigar
  • S. Hakim
  • Zehra MohsinEmail author
Original Article

Abstract

Objective

To evaluate the role of 17 α hydroxyprogesterone caproate (17OHPC) in the prevention of preterm labor in high risk asymptomatic patients with a history of preterm delivery.

Methods

The study included 96 patients with a singleton pregnancy and having a prior preterm birth. They were divided in 2 groups, group I (treatment group) included 46 asymptomatic patients who were given 17OHPC injections starting from 16–20 weeks till 36 weeks and group II (control group) included 50 patients who did not receive any treatment.

Results

The incidence of preterm delivery was found to be 6.9 %. The median gestational age at delivery was 36 weeks in group I and 33 W5D in controls. 50 % cases in group I and 80 % of controls delivered prematurely in the group with a prior preterm birth between 20–28 weeks.

Conclusion

In patients who had a prior history of a preterm delivery the recurrence of a preterm birth was less in the treated group as compared to controls. The median gestational age at delivery was significantly higher in 17OHPC treated patients with history of earliest prior preterm delivery at 20–28 weeks.

Keywords

Preterm Birth Preterm Delivery Preterm Labor Hydroxy Progesterone Spontaneous Preterm Birth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Chabra S, Patil N. Study of factors causing and arresting preterm labor. J Obstet Gynecol India. 2001;51:99–103.CrossRefGoogle Scholar
  2. 2.
    Kristenson J, Langhoff R. Implications of idiopathic preterm delivery for previous and subsequent pregnancy. Obstet Gynecol. 1995;86:800.CrossRefGoogle Scholar
  3. 3.
    Cousins LM, Hobel CJ. Serum progesterone and estradiol 17β levels in premature preterm labor. Am J Obstet Gynecol. 1977;127:712–5.Google Scholar
  4. 4.
    ACOG Committee opinion no. 291. Use of progesterone to reduce preterm birth. Obstet Gynecol. 2003;102:1115–1116.Google Scholar
  5. 5.
    Bloom SL, Yost NP, Mclntire DD, et al. Recurrence of preterm birth in singleton and twin pregnancy. Obstet Gynecol. 2001;98:379.PubMedCrossRefGoogle Scholar
  6. 6.
    Catherine Y, Spong MD, Meis PJ. Progesterone for prevention of recurrent preterm birth-impact of gestational age at previous delivery. Am J Obstet Gynecol. 2005;193:1127–31.CrossRefGoogle Scholar
  7. 7.
    Meis PJ, Klebanoff M. Prevention of recurrent preterm delivery by 17α OHPC. N Eng J Med. 2003; 2329–85.Google Scholar
  8. 8.
    Meis PJ. 17α OHPC for the prevention of preterm delivery. Obstet Gynecol. 2005;105:1128–35.PubMedCrossRefGoogle Scholar

Copyright information

© Federation of Obstetric & Gynecological Societies of India 2012

Authors and Affiliations

  1. 1.Department of Obstetrics & GynecologyJ N Medical College AligarhAligarhIndia

Personalised recommendations