Gonadotropin Levels in Hypothyroid Women of Reproductive Age Group

  • Neema AcharyaEmail author
  • Sourya Acharya
  • Samarth Shukla
  • S. A. Inamdar
  • M. Khatri
  • S. N. Mahajan
Original Article



To study serum gonadotropin (FSH, LH) levels in cases of subclinical and overt hypothyroid women in reproductive age group.

Material and Method

Female patients of reproductive age group attending thyroid clinic of Acharya Vinoba Bhave Hospital were included in the study. Detail menstrual history was taken, and serum FSH and LH levels were estimated by radio immuno assay method.


Eighty patients were included in the study, out of whom 46 (57.5%) had subclinical hypothyroidism and 34 (42.5%) had overt hypothyroidism. In subclinical hypothyroidism group the menstrual dysfunction which dominated in our study was oligomenorrhea (28.2%) followed by menorrhagia (17.39%). 39.13% had normal menstruation. In overt hypothyroidism group again it was oligomenorrhoea (23.5%) which was the principal menstrual abnormality followed by menorrhagia (17.64%). The percentage of females with normal menstruation was 47.05%. The levels of serum FSH and LH were significantly low in cases of both subclinical and overt hypothyroid women. They were significantly low when done between day 2 and 5 of the cycle.


Hypothyroidism decreases levels of serum FSH and serum LH. Subclinical hypothyroidism is one of the major etiological factors of infertility. Autoantibodies against thyroid should be searched for in cases of female patients with infertility.


Serum gonadotropins Follicular stimulating hormone (FSH) Luteinizing hormone (LH) Hypothyroidism 


  1. 1.
    Akande EO. Plasma concentration of gonadotrophins, oestrogen and progesterone in hypothyroid women. Br J Obstet Gynaecol. 1975;82:552–6.PubMedCrossRefGoogle Scholar
  2. 2.
    Armada-Dias L, Carvalhe JJ, Breltenbach MM, et al. Is the infertility in hypothyroidism mainly due to ovarian or pituitary functional changes? Braz J Med Biol Res. 2001;34:1209–15.PubMedCrossRefGoogle Scholar
  3. 3.
    Goldsmith RE, Sturgis SH, Lennan J, et al. The menstrual pattern in thyroid disease. J Clin Endocrinol Metab. 1952;12:846–55.PubMedCrossRefGoogle Scholar
  4. 4.
    Mussey H. The thyroid and its diseases. In: Means JH, editor. Philadelphia: J H Jones & Co.; 1948.Google Scholar
  5. 5.
    Joshi JV, Bhandakar SD, Chadha M, et al. Menstrual irregularities and lactation failure may precede thyroid dysfunction or goiter. J Postgrad Med. 1993;39:137–41.PubMedGoogle Scholar

Copyright information

© Federation of Obstetric & Gynecological Societies of India 2011

Authors and Affiliations

  • Neema Acharya
    • 1
    • 4
    Email author
  • Sourya Acharya
    • 2
  • Samarth Shukla
    • 3
  • S. A. Inamdar
    • 1
  • M. Khatri
    • 1
  • S. N. Mahajan
    • 2
  1. 1.Department of Obstetrics and GynaecologyDatta Meghe Institute of Medical SciencesWardhaIndia
  2. 2.Department of MedicineDatta Meghe Institute of Medical SciencesWardhaIndia
  3. 3.Department of PathologyDatta Meghe Institute of Medical SciencesWardhaIndia
  4. 4.Department of Obstetrics and GynaecologyAcharya Vinoba Bhave Rural Hospital, Sawangi MegheWardhaIndia

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