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Role of edible mushroom as a potent therapeutics for the diabetes and obesity

Abstract

Diabetes and obesity are the most frequently found disease worldwide. Several factors are responsible for obesity, i.e., imbalance in energy expenditure, environmental factors, feeding habit, lifestyle, etc., which can also be responsible for type 2 diabetes mellitus. There are several synthetic drugs available to combat these diseases which have some side effects on sufferers. Therefore, people are shifting towards inexpensive, effective, widely available natural and herbal medicines. Edible mushrooms, which have been used from ancient time to cure these diseases, contain anti-oxidant, fibers, triterpenoids, alkaloid, and other phytochemicals. Comatin, β-glucan, Tremellastin, and Lentinan KS-2 are active chemicals of mushrooms which show great effect on diabetes mellitus and obesity by modulating either cellular function or biochemical pathways. Here, in this review, we have discussed the potential role of edible mushrooms and its biochemicals in control of diabetes and obesity. Using Bioinformatics, we can find the specific targets of theses biochemicals, so that these can be more effective.

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Acknowledgements

SKD is thankful to the University Grants Commission (UGC), New Delhi, for granting research fellowship. SKD also acknowledge DBT-New Delhi facilities of Centre of Biotechnology, University of Allahabad, Prayagraj, India.

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SKD contributed in writing, drawing the figures and tables in this review article. VKC, DM, AB, and AT designed all the content of the article. MPS drafted and reviewed the manuscript.

Correspondence to M. P. Singh.

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Dubey, S.K., Chaturvedi, V.K., Mishra, D. et al. Role of edible mushroom as a potent therapeutics for the diabetes and obesity. 3 Biotech 9, 450 (2019). https://doi.org/10.1007/s13205-019-1982-3

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Keywords

  • Edible mushroom
  • Bioactive compounds
  • Diabetes mellitus
  • Insulin
  • Anti-diabetic