3 Biotech

, 9:448 | Cite as

Recent systems biology approaches for probiotics use in health aspects: a review

  • Monika Yadav
  • Pratyoosh ShuklaEmail author
Review Article


The market of probiotics is growing dynamically for the food and supplements, which provides better health to an individual. Probiotics are used as dietary management for diseases, but it varies between regions and persons. Systems biology can help in resolving the strain specificity of probiotics by studying their genome level organization. In this review, we have compiled facets of systems biology and next-generation omics methods such as metagenomics, proteomics and metabolomics. These tools are crucial for the optimization of the metabolic processes in probiotics and hence, their use for human health. The limitations and challenges associated with the development of probiotics involve their stability and function in different individuals. Systems biology facilitates emerging metabolic engineering approaches to improve probiotics strain for their broader application. This review provides comprehensive and updated knowledge of engineered probiotics as therapeutics and various challenges in the development of engineered probiotics.


Probiotics Systems biology Proteomics Metabolomics Metagenomics 



The authors acknowledge Maharshi Dayanand University, Rohtak, India for providing infrastructure facility. PS acknowledges the infrastructural support from Department of Science and Technology, New Delhi, Govt. of India, through FIST grants (Grant No. 1196 SR/FST/LS-I/2017/4) and Department of Biotechnology, Government of India (Grant no. BT/PR27437/BCE/8/1433/2018).

Author contribution

Both authors have equal contribution.

Compliance with ethical standards

Conflict of interest

The authors don’t have any conflict of interest.

Ethical statement

This review article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© King Abdulaziz City for Science and Technology 2019

Authors and Affiliations

  1. 1.Enzyme Technology and Protein Bioinformatics Laboratory, Department of MicrobiologyMaharshi Dayanand UniversityRohtakIndia

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