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3 Biotech

, 9:431 | Cite as

FlavoDb: a web-based chemical repository of flavonoid compounds

  • Baban S. Kolte
  • Sanjay R. Londhe
  • Kamini T. Bagul
  • Shristi P. Pawnikar
  • Mayuri B. Goundge
  • Rajesh N. Gacche
  • Rohan J. MeshramEmail author
Original Article

Abstract

There are many online resources that focus on chemical diversity of natural compounds, but only handful of resources exist that focus solely on flavonoid compounds and integrate structural and functional properties; however, extensive collated flavonoid literature is still unavailable to scientific community. Here we present an open access database ‘FlavoDb’ that is focused on providing physicochemical properties as well as topological descriptors that can be effectively implemented in deducing large scale quantitative structure property models of flavonoid compounds. In the current version of database, we present data on 1, 19,400 flavonoid compounds, thereby covering most of the known structural space of flavonoid class of compounds. Moreover, effective structure searching tool presented here is expected to provide an interactive and easy-to-use tool for obtaining flavonoid-based literature and allied information. Data from FlavoDb can be freely accessed via its intuitive graphical user interface made available at following web address: http://bioinfo.net.in/flavodb/home.html.

Keywords

Phytochemicals Flavone Flavanones Isoflavones Neoflavonoids Topological descriptor Drug discovery QSPR Database 

Notes

Acknowledgements

We would like to thank Dr. Paul Thiessen and Dr. Evan Bolton, staff from NCBI Structure group for their continuous guidance and suggestion to obtain data on literature and MeSH titles from NCBI resource included in this study. We are also thankful to Dr. Sangeeta Sawant, Director, Bioinformatics Centre, SPPU, Pune for providing continuous encouragement and infrastructure for database development. We acknowledge Mr. Bhushan Solanki for critical suggestion during development of this resource. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards:

Conflicts of interest

The authors declare no conflict of interest.

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Copyright information

© King Abdulaziz City for Science and Technology 2019

Authors and Affiliations

  1. 1.Bioinformatics CentreSavitribai Phule Pune UniversityPuneIndia
  2. 2.Department of BiotechnologySavitribai Phule Pune UniversityPuneIndia
  3. 3.Institute of Biochemistry and Molecular Biology, Department of ChemistryUniversity of HamburgHamburgGermany
  4. 4.Center for BioinformaticsUniversity of KansasLawrenceUSA

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