Prospecting prebiotics, innovative evaluation methods, and their health applications: a review
Prebiotics are necessary natural and synthetic food ingredients that help in the growth and development of gut microflora. There is a complex relationship between gut dysbiosis and microbes, so alteration in both probiotics and prebiotics can reduce illness of gut, which further plays a decisive role in human health. The prebiotic efficiency can be validated using various in vitro and in vivo experiments, and this gives an important insight to this field. This review focuses on these aspects including the standardized assessment of prebiotics and its metabolic products for customary applications. This review has also summarized the mechanism of their beneficial actions such as immunomodulation, nutrient absorption, pathogen inhibition, etc., and its significance in human nutrition. In addition to this, some fascinating applications of prebiotics in health-related disorders have also discussed, with current challenges in this facet.
KeywordsPrebiotics Gut microbiota Gastrointestinal tract Oligosaccharides Human health
The authors acknowledge Maharshi Dayanand University, Rohtak, India, for providing infrastructure facility. IK acknowledges the support as University Research Scholarship by M.D. University, Rohtak, India (Grant No. R&S/R-15/19/1868). PS acknowledges the infrastructural support from Department of Science and Technology, New Delhi, Govt. of India, FIST grant (Grant No. 1196 SR/FST/LS-I/ 2017/4) and Department of Biotechnology, Government of India (Grant No. BT/PR27437/BCE/8/1433/2018). PS also acknowledges Department of Microbiology, Barkatullah University, Bhopal, India, for their infrastructural support for D.Sc. work.
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Conflict of interest
All authors declare that they have no conflict of interest.
- Bajury DM, Nashri SM, King Jie Hung P, Sarbini SR (2017) Evaluation of potential prebiotics: a review. Food Rev Int 00:1–26Google Scholar
- Díaz-Vergara L, Pereyra CM, Montenegro M et al (2017) Encapsulated whey–native yeast Kluyveromyces marxianus as a feed additive for animal production. Food Addit Contam Part A 34:750–759Google Scholar
- Garcia-Mazcorro JF, Barcenas-Walls JR, Suchodolski JS, Steiner JM (2017) Molecular assessment of the fecal microbiota in healthy cats and dogs before and during supplementation with fructo-oligosaccharides (FOS) and inulin using high-throughput 454-pyrosequencing. PeerJ 5:e3184CrossRefGoogle Scholar
- Gibson GR, Hutkins R, Sanders ME et al (2017) Expert consensus document: The international scientific association for probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 4(8):491Google Scholar
- Hasle G (2018) Reply to comment “Do prebiotics reduce the risk of travelers ‘diarrhea? Promising but more research needed.” J Travel Med 25:tax086Google Scholar
- Serova LI, Nwokafor C, Van Bockstaele EJ, Reyes BA, Lin X, Sabban EL (2019) Single prolonged stress PTSD model triggers progressive severity of anxiety, altered gene expression in locus coeruleus and hypothalamus and effected sensitivity to NPY. Eur Neuropsychopharmacol 29:482–492CrossRefGoogle Scholar
- Zoumpopoulou G, Kazou M, Alexandraki V (2018) Probiotics and prebiotics: an overview on recent trends. In: Probiotics and prebiotics in animal health and food safety. Springer, New York, pp 1–34Google Scholar