Renoprotective effect of cinnamaldehyde in food color induced toxicity
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Present study reports the effects of metanil yellow, a non-permitted food colouring dye, on the biomarkers of oxidative stress and kidney function in blood and renal tissue of albino Wistar rats and its mitigation by cinnamaldehyde, a major phytoconstituents of cinnamon. Oral administration of metanil yellow in rats caused about 70% reduction in ferric reducing ability (FRAP 5.1 μM/L) and 50% decline in reduced glutathione (GSH 59.27 nM/mg protein) content in plasma with simultaneous increase in serum creatinine level. In kidney tissues, activities of superoxide dismutase (SOD), catalase and GSH dropped while malondialdehyde (MDA) content increased. Co-administration of cinnamaldehyde with metanil yellow showed considerable restorative effect on the biomarkers of plasma antioxidant status and kidney function i.e., FRAP (11.5 μM/L), GSH (83–88.5 nM/mg protein), urea, creatinine, SOD, catalase and MDA. Administration of cinnamaldehyde restored the kidney enzyme activities up to 75% of the base level. The study revealed that reno-protective action of cinnamaldehyde was mediated by lowering oxidative stress level.
KeywordsCinnamaldehyde Metanil yellow Oxidative stress Renoprotective Food colour
UKS, RK, AG and RG acknowledge financial support in the form of UGC CRET fellowships. All authors also acknowledge UGC-SAP and DST-FIST Facilities of the Department of Biochemistry, University of Allahabad, Allahabad.
Compliance with ethical standards
Conflict of interests
The authors declare that they do not have any conflict of interests.
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