Euphorbia milii extract-mediated zinc oxide nanoparticles and their antinociceptive, muscle relaxant, and sedative activities for pain management in pediatric children

  • Tong Shen
  • Qun Wang
  • Chengjun Liu
  • Fengfei Yu
  • Da Yu
  • Chengling LiEmail author
Original Article


Nanotechnology has been recognized to have prospective future for improving therapy effectiveness and decreasing the undesirable impacts of herbal medicines. The utilization of several crops in conventional medicines has endorsed biological studies on Euphorbia species. It has been indicated that several Euphorbia species have powerful analgesic as well as sedative impacts. Zinc oxide nanoparticles prepared using Euphorbia milii aqueous extract (ZnO NPs-EM) have been produced, distinguished as well as evaluated for sedative, muscle relaxant, and antinociceptive activity in the current study. In comparison with the aqueous extract of E. milii, ZnO NPs developed an obvious antinociceptive impact at concentrations of 10 and 20 mg/kg. At a concentration of 20 and 10 mg/kg after 90, 60, and 30 min, ZnO NPs-EM displayed an important muscle relaxing impact in the rota-rod experiment. An important sedative impact (P < 0.05) of ZnO NPs-EM at 20 and 10 mg/kg was observed in an open-field experiment. These findings suggested that the ZnO NPs enhanced the effectiveness of the aqueous sample of E. milii, and showed important sedative, relaxing muscle, and analgesic characteristics.


Pain management ZnO NPs Polyphenols 



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Copyright information

© King Abdulaziz City for Science and Technology 2019

Authors and Affiliations

  • Tong Shen
    • 1
  • Qun Wang
    • 1
  • Chengjun Liu
    • 1
  • Fengfei Yu
    • 1
  • Da Yu
    • 1
  • Chengling Li
    • 1
    Email author
  1. 1.Department of PediatricsLinyi Central HospitalYishuiChina

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