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Nanoliposomal system of rosemary essential oil made by specific human cell phospholipids and evaluation of its anti-cancer properties

  • Shahrzad SalariEmail author
  • Reza Salari
Original Article
  • 8 Downloads

Abstract

Herbal extracts including herbal essential oils typically have lesser side effects when compared to synthetic chemical drugs. Their use in free form is limited due to their chemical instability and sensitivity to oxidation. One approach to improving their stability and delivery is to encapsulate the active herbal compounds in lipid carriers such as nanoliposomes. Rosemary (Rosmarinus officinalis L.) is a common herbal medicine with useful antioxidant and antimicrobial effects. In this study, the rosemary essential oil was first extracted and its compounds were characterized using gas chromatography and mass spectrometry (GC–MS). Then nanoliposomal carriers were constructed using both sonication and filtration techniques and their size and release pattern were evaluated. Finally, the anti-cancer properties of the free and encapsulated rosemary essential oil on MCF7 cell line (Michigan Cancer Foundation-7) were evaluated. Our results show that the liposomal essential oil has higher toxic effects on the MCF7 cell line due to improved drug delivery.

Keywords

Nanoliposomes Drug delivery Gas chromatography and mass spectrometry (GC–MS) Rosemary (Rosmarinus officinalis L.) Essential oil 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© King Abdulaziz City for Science and Technology 2019

Authors and Affiliations

  1. 1.Shahid Bahonar University of KermanKermanIran
  2. 2.Tehran UniversityTehranIran

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