Nanoliposomal system of rosemary essential oil made by specific human cell phospholipids and evaluation of its anti-cancer properties
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Herbal extracts including herbal essential oils typically have lesser side effects when compared to synthetic chemical drugs. Their use in free form is limited due to their chemical instability and sensitivity to oxidation. One approach to improving their stability and delivery is to encapsulate the active herbal compounds in lipid carriers such as nanoliposomes. Rosemary (Rosmarinus officinalis L.) is a common herbal medicine with useful antioxidant and antimicrobial effects. In this study, the rosemary essential oil was first extracted and its compounds were characterized using gas chromatography and mass spectrometry (GC–MS). Then nanoliposomal carriers were constructed using both sonication and filtration techniques and their size and release pattern were evaluated. Finally, the anti-cancer properties of the free and encapsulated rosemary essential oil on MCF7 cell line (Michigan Cancer Foundation-7) were evaluated. Our results show that the liposomal essential oil has higher toxic effects on the MCF7 cell line due to improved drug delivery.
KeywordsNanoliposomes Drug delivery Gas chromatography and mass spectrometry (GC–MS) Rosemary (Rosmarinus officinalis L.) Essential oil
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Conflict of interest
The authors declare that they have no conflict of interest.
- Anonymous A (2010) Scientific opinion of the panel on the use of oregano and lemon balm extracts as a food additive. EFSA Journal 8(2):1514–1524Google Scholar
- Begum K, Sarker A, Shimu IJ, Chowdhury MMI, Jalil R (2016) Characterization of nanoemulsion prepared from self-emulsifying rifampicin and its antibacterial effect on staphylococcus aureus and stap. Epidermidis isolated from AcneDhaka Uni J Pharm SciGoogle Scholar
- Benita S (2006) Microencapsulation Methods and Industrial Applications, 2nd edn. CRC Press, USA, pp 44–55Google Scholar
- Celia C, Trapasso E, Locatelli M, Navarra M, Ventura CA, Wolfram J, Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells. Colloids Surfaces B Biointerfaces, 2013Google Scholar
- Duncan R, Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer. EndocrRelat Cancer, 2005; 189 – 99Google Scholar
- Kubo T (2000) Targeted delivery of anticancer drugs with intravenously administered magnetic liposomes in osteosarcoma-bearing hamsters. Int J Oncol 17(2):309–315Google Scholar
- Suleymanoglu E (2004) A nanoscale polynucleotide-neutral liposome self-assemblies formulated. Rev Electron Biomed 2:13–25Google Scholar
- Wu G (2009) Chap. 14 Synthesis, Characterization, and Optical Response of Gold Nanoshells Used to Trigger Release from Liposomes. In: Methods in Enzymology. D. Nejat, Editor; 279 – 89Google Scholar