Development of biocompatible 1D CuO nanoneedles and their potential for sensitive, mass-based detection of anti-tuberculosis drugs

  • Khizra Bano
  • Sadia Z. BajwaEmail author
  • Nicole J. Bassous
  • Thomas J. Webster
  • Ayesha Shaheen
  • Ayesha Taj
  • Sadaf Hameed
  • Bushra Tehseen
  • Zhifei Dai
  • M. Zubair Iqbal
  • Waheed S. KhanEmail author
Original Article


Unique physical and chemical properties make 1D nanomaterials very attractive and their window of applications is broadened by the addition of biocompatible materials. Similarly, the massive side effects associated with the frequent use of antibiotics make it crucial to analyze the quantity and detect even the subservient amounts of antibiotics in vivo following their administration to patients. The present study describes the one-pot solvothermal approach to produce 1D CuO nanoneedles. Microscopic investigations revealed the presence of nanoneedles of about 8–15 nm in size with negative surface charge (− 30.51 mV). These structures were explored for the targeted detection of the anti-tubercular agent rifampicin. This developed interface showed excellent sensitivity, with the limit of detection as low as 9.4 nM and the limit of quantification as 20 nM. This sensor exhibited good selectivity towards the structural analogs (rifabutene, rifapentine) of the analyte. This study represents the potential of 1D nanomaterial in biomedical applications such as the development of interfaces for online monitoring.


Nanoneedles 1D Copper oxide Gelatin Quartz crystal microbalance Antibiotics 



We at Nanobiotechnology Group, NIBGE, Pakistan, highly acknowledge Higher Education Commission of Pakistan for providing financial assistance under the Indigenous scholarship grant (SAP No.1500021831/7107), and for the provision of IRSIP Fellowship (No: 1-8/HEC/HRD/2017/7965). We are also thankful to the Webster’s Nanomedicine group at Chemical Engineering Department, Northeastern University for providing the work facilities. Also, we are thankful to Will Fowle from Northeastern University for microscopic studies.

Compliance with ethical standards

Conflict of interest

There are no competing financial interests declared by the authors.

Supplementary material

13204_2019_1003_MOESM1_ESM.docx (114 kb)
Supplementary material 1 (DOCX 114 KB)


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Copyright information

© King Abdulaziz City for Science and Technology 2019

Authors and Affiliations

  1. 1.Nanobiotech GroupNational Institute for Biotechnology and Genetic Engineering (NIBGE)FaisalabadPakistan
  2. 2.Department of Chemical EngineeringNortheastern UniversityBostonUSA
  3. 3.Pakistan Institute of Engineering and Applied SciencesIslamabadPakistan
  4. 4.Department of Biomedical Engineering, College of EngineeringPeking UniversityBeijingChina
  5. 5.Department of Materials Engineering, College of Materials and TextilesZhejiang Sci-Tech UniversityHangzhouPeople’s Republic of China

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