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Development of biocompatible 1D CuO nanoneedles and their potential for sensitive, mass-based detection of anti-tuberculosis drugs

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Abstract

Unique physical and chemical properties make 1D nanomaterials very attractive and their window of applications is broadened by the addition of biocompatible materials. Similarly, the massive side effects associated with the frequent use of antibiotics make it crucial to analyze the quantity and detect even the subservient amounts of antibiotics in vivo following their administration to patients. The present study describes the one-pot solvothermal approach to produce 1D CuO nanoneedles. Microscopic investigations revealed the presence of nanoneedles of about 8–15 nm in size with negative surface charge (− 30.51 mV). These structures were explored for the targeted detection of the anti-tubercular agent rifampicin. This developed interface showed excellent sensitivity, with the limit of detection as low as 9.4 nM and the limit of quantification as 20 nM. This sensor exhibited good selectivity towards the structural analogs (rifabutene, rifapentine) of the analyte. This study represents the potential of 1D nanomaterial in biomedical applications such as the development of interfaces for online monitoring.

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Acknowledgements

We at Nanobiotechnology Group, NIBGE, Pakistan, highly acknowledge Higher Education Commission of Pakistan for providing financial assistance under the Indigenous scholarship grant (SAP No.1500021831/7107), and for the provision of IRSIP Fellowship (No: 1-8/HEC/HRD/2017/7965). We are also thankful to the Webster’s Nanomedicine group at Chemical Engineering Department, Northeastern University for providing the work facilities. Also, we are thankful to Will Fowle from Northeastern University for microscopic studies.

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Correspondence to Sadia Z. Bajwa or Waheed S. Khan.

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Novelty statement: In this study, we have introduced a one-pot and straight forward method for the preparation of 1D CuO nanoneedles for mass-sensitive detection of antibiotics. The morphology embraces many special features such as greater surface area and 1D quantum effects which lead to more number of binding sites, in general. This sensor design brings excellent sensitivity. This is the first report such structures are being reported for online monitoring of bioanalytes.

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Bano, K., Bajwa, S.Z., Bassous, N.J. et al. Development of biocompatible 1D CuO nanoneedles and their potential for sensitive, mass-based detection of anti-tuberculosis drugs. Appl Nanosci 9, 1341–1351 (2019). https://doi.org/10.1007/s13204-019-01003-7

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