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Evaluation of the hepatoprotective effect of combination between fermented camel milk and Rosmarinus officinalis leaves extract against CCl4 induced liver toxicity in mice

  • Houda Hamed
  • khaled Bellassoued
  • Abdelfattah El Feki
  • Ahmed Gargouri
Original Article
  • 73 Downloads

Abstract

The present study was conducted to evaluate the in vitro antioxidant activity of fermented camel milk with Lactococcus lactis subsp. cremoris (FCM-LLC) alone, Rosmarinus officinalis extract (R) alone and their combination and to investigate their hepatopreventive effects against CCl4 liver damage in mice. The antioxidant activity in vitro of FMC-LLC supplemented with R exhibited the highest free radical scavenging and ferric reducing power activities. The results showed that the pretreatment with a combination of FMC-LLC and R significantly alleviated the increased levels of hepatic markers and the elevated lipid levels induced by CCl4 in mice. Meanwhile, the enzymatic antioxidants activities (superoxide dismutase, glutathione peroxidase, and catalase) and GSH level in liver significantly were increased while the malondialdehyde level was significantly improved by pretreatment with FMLLC plus R. These data suggest that FCM-LLC in combination with R. officinalis extract possesses better antioxidant and hepatoprotective activity than FMC-LLC alone.

Keywords

Carbon tetrachloride Fermented camel milk Hepatoprotection Lacotococus lactis subsp. cremoris Rosmarinus officinalis 

Notes

Acknowledgements

This research was supported by the Tunisian Ministry of higher Education and Scientific Research.

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Copyright information

© Association of Food Scientists & Technologists (India) 2019

Authors and Affiliations

  • Houda Hamed
    • 1
  • khaled Bellassoued
    • 1
  • Abdelfattah El Feki
    • 1
  • Ahmed Gargouri
    • 2
  1. 1.Laboratory of Animal Ecophysiology, Faculty of SciencesSfax UniversitySfaxTunisia
  2. 2.Research Unit of Toxicology, Environmental Microbiology and Health, Faculty of Science of SfaxUniversity of SfaxSfaxTunisia

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