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Journal of Food Science and Technology

, Volume 52, Issue 9, pp 5377–5392 | Cite as

Bioactive peptides of animal origin: a review

  • Z. F. Bhat
  • Sunil Kumar
  • Hina Fayaz Bhat
Review Article

Abstract

Bioactive peptides are specific protein fragments which, above and beyond their nutritional capabilities, have a positive impact on the body’s function or condition which may ultimately influence health. Although, inactive within the sequence of the parent proteins, these peptides can be released during proteolysis or fermentation and play an important role in human health by affecting the digestive, endocrine, cardiovascular, immune and nervous systems. Several peptides that are released in vitro or in vivo from animal proteins have been attributed to different health effects, including antimicrobial properties, blood pressure-lowering (ACE inhibitory) effects, cholesterol-lowering ability, antithrombotic and antioxidant activities, opioid activities, enhancement of mineral absorption and/or bioavailability, cytomodulatory and immunomodulatory effects, antiobesity, and anti-genotoxic activity. Several functional foods based on the bioactivities of these peptides with scientifically evidenced health claims are already on the market or under development by food companies. Consumer’s increasing interest in these products has given an impetus to the food industry and scientific sector who are continuously exploring the possibilities for the development of new functional products based on these peptides. In this review, we describe above stated properties of bioactive peptides of animal origin.

Keywords

Bioactive peptides Animal origin Production Bioactivities 

References

  1. Agyei D, Danquah MK (2011) Industrial scale manufacturing of pharmaceutical grade bioactive peptides. Biotechnol Adv 29(3):272–277CrossRefGoogle Scholar
  2. Aihara K, Kajimoto O, Hirata H, Takahashi R, Nakamura Y (2005) Effect of powdered fermented milk with Lactobacillus helveticus on subjects with high normal blood pressure or mild hypertension. J Am Coll Nutr 24(4):257–265CrossRefGoogle Scholar
  3. Akai S, Alizadeh-Pasdar N (2006) Rational designing of bioactive peptides. In: Mine V, Shahidi F (eds) Nutraceutical proteins and peptides in health and disease. Taylor and Francis, FL, p 565–582Google Scholar
  4. Arihara K (2004) Functional foods. In: Jensen W, Devine C, Dikemann M (eds) Encyclopedia of meat sciences, vol 1. Elesevier Science, London, pp 492–499CrossRefGoogle Scholar
  5. Arihara K (2006) Strategies for designing novel functional meat products. Meat Sci 74:219–229CrossRefGoogle Scholar
  6. Arihara K, Nakashima Y, Mukai T, Ishikawa S, Itoh M (2001) Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle proteins. Meat Sci 57:319–324CrossRefGoogle Scholar
  7. Bah CSF, Bekhit A, El-Din A, Carne A, McConnellc MA (2013) Slaughterhouse blood: an emerging source of bioactive compounds. Com Rev Food Sci Food Saf 12:314–331CrossRefGoogle Scholar
  8. Baldauf F, Belter J, Horn U, Krug M, Metzlaff M, Polley A (1994) In β-casomorphins and related peptides: recent developments. V Brantl and H Teschemacher Eds, VCH Veinheim, pp 73–80Google Scholar
  9. Becker GL (1993) Preserving food and health: antioxidants make functional, nutritious preservatives. Food Process (Chicago) 12:54–56Google Scholar
  10. Berrocal R, Chanton S, Juilleart MA, Pavillard B, Scherz JC, Jost R (1989) Tryptic phosphopeptides from whole casein. II Physicochemical properties related to the solubilization of calcium. Dairy Res 56:335–341CrossRefGoogle Scholar
  11. Chabance B, Marteau P, Rambaud JC, Migliore-Samour D, Jollès P, Boynard M, Perrotin P, Buillet R, Fiat AM (1998) Casein peptide release and passage to the blood in humans during digestion of milk or yogurt. Biochimie 80:155–165CrossRefGoogle Scholar
  12. Chakrabarti S, Jahandideh F, Wu J (2014) Food-derived bioactive peptides on inflammation and oxidative stress. Biomed Res. doi: 10.1155/2014/608979 Google Scholar
  13. Chen GW, Tsai JS, Sun Pan B (2007) Purification of angiotensin I-converting enzyme inhibitory peptides and antihypertensive effect of milk produced by protease facilitated lactic fermentation. Int Dairy J 17:641–647CrossRefGoogle Scholar
  14. Chiang WE, Cordle CT, Thomas RL (1995) Casein hydrolysate produced using a formed-in-place membrane reactor. J Food Sci 60:1349–1352CrossRefGoogle Scholar
  15. Clare DA, Swaisgood HE (2000) Bioactive milk peptides: a prospectus. J Dairy Sci 83:1187–1195CrossRefGoogle Scholar
  16. Czapla MA, Champion HC, Zadina JE, Kastin AJ, Hackler L, Ge LJ, Kadowitz PJ (1998) Endomorphin 1 and 2, endogenous mu-opioid agonists, decrease systemic arterial pressure in the rat. Life Sci 62:PL175–PL179CrossRefGoogle Scholar
  17. Danquah MK, Agyei D (2012) Pharmaceutical applications of bioactive peptides. Biotechnol 1(2):5Google Scholar
  18. Dave LA, Montoya CA, Rutherfurd SM, Moughan PJ (2014) Gastrointestinal endogenous proteins as a source of bioactive peptides - an In silico study. PLoS ONE 9(6):e98922CrossRefGoogle Scholar
  19. deCosta EL, Rocha Montijo JA, Netto FM (2007) Effect of heat and enzymatic treatment on the antihypertensive activity of whey protein hydrolysates. Int Dairy J 17:632–640CrossRefGoogle Scholar
  20. Diplock AT, Aggett PJ, Ashwell M, Bornet F, Fern EB, Roberfroid MB (2000) Scientific concepts of functional foods in Europe: consensus document. In: Buttriss J, Saltmarsh M (eds) Functional foods II- claims and evidence. The Royal Society of Chemistry, Cambridge, p 8–59Google Scholar
  21. Donkor O, Henriksson A, Vasiljevic T, Shah NP (2007) Proteolytic activity of dairy lactic acid bacteria and probiotics as determinant of growth and in vitro angiotensin-converting enzyme inhibitory activity in fermented milk. Lait 86:21–38CrossRefGoogle Scholar
  22. Dziuba B, Dziuba M (2014) Milk proteins-derived bioactive peptides in dairy products: molecular, biological and methodological aspects. Acta Sci Pol Technol Aliment 13(1):5–25CrossRefGoogle Scholar
  23. Dziuba J, Iwaniak A (2006) Database of protein and bioactive peptide sequences. In: Mine V, Shahidi F (eds) Nutraceutical proteins and peptides in health and disease. Taylor and Francis, FL, p 543–563Google Scholar
  24. Erdmann K, Cheung BWY, Schröder H (2008) The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J Nutr Biochem 19:643–654CrossRefGoogle Scholar
  25. Ferreira IMPLVO, Pinho O, Mota MV, Tavares P, Pereira A, Goncalves MP, Torres D, Rocha C, Teixeira JA (2007) Preparation of ingredients containing an ACE inhibitory peptide by tryptic hydrolysis of whey protein concentrates. Int Dairy J 17:481–487CrossRefGoogle Scholar
  26. Fiat AM, Miglilore-Samour D, Jollès P, Crouet L, Collier C, Caen J (1993) Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immuno-modulating activities. J Dairy Sci 76:301–310CrossRefGoogle Scholar
  27. FitzGerald R, Murray BA (2006) Bioactive peptides and lactic fermentations. Int J Dairy Technol 59:118–125CrossRefGoogle Scholar
  28. FitzGerald RJ, Murray BA, Walsh DJ (2004) Hypotensive peptides from milk proteins. J Nutr 134:980S–988SGoogle Scholar
  29. Fuglsang A, Rattray FP, Nilsson D, Nyborg NCB (2003) Lactic acid bacteria: inhibition of angiotensin converting enzyme in vitro and in vivo. Antonie Van Leeuwenhoek 83:27–34CrossRefGoogle Scholar
  30. Fu-yuan C, Yu-tse L, Tien-chun W, Liang-chuan L, Sakata R (2008) The development of angiotensin I-converting enzyme inhibitor derived from chicken bone protein. Anim Sci J 79:122–128CrossRefGoogle Scholar
  31. Gagnaire V, Pierre A, Molle D, Leonil J (1996) Phosphopeptides interacting with colloidal calcium phosphate isolated by tryptic hydrolysis of bovine casein micelles. J Dairy Res 63:405–422CrossRefGoogle Scholar
  32. Gauthier SF, Pouliot Y, Saint-Sauveur D (2006) Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins. Int Dairy J 16:1315–1323CrossRefGoogle Scholar
  33. Gill I, López-Fandino R, Jorba X, Vulfson EN (1996) Biologically active peptides and enzymatic approaches to their production. Enzym Microb Technol 18:162–183CrossRefGoogle Scholar
  34. Girgih AT, Udenigwe CC, Hasan FM, Gill TA, Aluko RE (2013) Antioxidant properties of Salmon (Salmo salar) protein hydrolysate and peptide fractions isolated by reverse phase HPLC. Food Res Int 52(1):315–322CrossRefGoogle Scholar
  35. Gobbetti M, Minervini F, Rizzello CG (2004) Angiotensin I converting-enzyme-inhibitory and antimicrobial bioactive peptides. Int J Dairy Technol 57:172–188CrossRefGoogle Scholar
  36. Gobbetti M, Minervini F, Rizzello CG (2007) Bioactive peptides in dairy products. In: Hui YH (ed) Handbook of foodproducts manufacturing. Wiley, Hoboken, pp 489–517CrossRefGoogle Scholar
  37. Gomez-Ruiz JA, Ramos M, Recio I (2002) Angiotensin-converting-enzyme-inhibitory peptides in Manchengo cheeses manufactured with different starter cultures. Int Dairy J 12:697–706CrossRefGoogle Scholar
  38. Gómez-Ruiz JA, Ramos M, Recio I (2004) Angiotensin converting enzyme-inhibitory activity of peptides isolated from Manchego cheese. Stability under simulated gastrointestinal digestion. Int Dairy J 14:1075–1080CrossRefGoogle Scholar
  39. de Llano Gonzalez D, Sanchez CP (2003) Peptides. In: Caballero B, Trugo LC, Finglas PM (eds) Encyclopedia of food science and nutrition, 2nd edn. Acedemic Press, London, pp 4468–4473CrossRefGoogle Scholar
  40. Guesdon B, Pichon L, Tome D 2006. In: Y Mine, F Shahidi (Eds) Nutraceutical proteins and peptides in health and disease. Taylor and Francis Group, Boca Raton, pp 367–376.Google Scholar
  41. Guha P, Kaptan E, Bandyopadhyaya G, Kaczanowska S, Davila E, Thompson K, Martin SS, Kalvakolanu DV, Vasta GR, Ahmed H (2013) Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis. Proc Natl Acad Sci. doi: 10.1073/pnas.1202653110 Google Scholar
  42. Hajirostamloo B (2010) Bioactive component in milk and dairy product. World Acad Sci Eng Technol 72:162–166Google Scholar
  43. Haque E, Chand R (2008) Antihypertensive and antimicrobial bioactive peptides from milk proteins. Eur Food Res Technol 227:7–15CrossRefGoogle Scholar
  44. Harada K, Maeda T, Hasegawa Y, Tokunaga T, Tamura Y, Koizumi T (2010) Antioxidant activity of fish sauces including puffer (Lagocephalus wheeleri) fish sauce measured by the oxygen radical absorbance capacity method. Mol Med Rep 3(4):663–668CrossRefGoogle Scholar
  45. Hartmann R, Gunther S, Martin D, Meisel H, Pentzien AK, Schlimme E, Scholz N (2000) Cytochemical model systems for the detectionand characterization of potentially bioactive milk components. Kiel Milchwirtschaftliche Forschungsberichte 52:61–85Google Scholar
  46. Hata Y, Yamamoto M, Ohni H, Nakajima K, Nakamura Y, Takano T (1996) A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr 64:767–771Google Scholar
  47. Hau J, Cazes D, Fay LB (1997) Comprehensive study of the beefy meaty peptide. J Agric Food Chem 45:1351–1355CrossRefGoogle Scholar
  48. Hipkiss AR, Brownson CA (2000) A possible new role for the antiageing peptide carnosine. Cell Mol Life Sci 57:747–753CrossRefGoogle Scholar
  49. Hirota T, Ohki K, Kawagishi R, Kajimoto Y, Mizuno S, Nakamura Y, Kitakaze M (2007) Casein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile-Pro-Pro improves vascular endothelial function independent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin-converting enzyme. Hypertens Res 30:489–496CrossRefGoogle Scholar
  50. Host A, Halken S (2004) Hypoallergenic formulas-when, to whom and how long: after more than 15 years we know the right indication. Allergy 59:45–52CrossRefGoogle Scholar
  51. Hsu KC, Li-Chan ECY, Jao CL (2010) Antiproliferative activity of peptides prepared from enzymatic hydrolysates of tuna dark muscle on human breast cancer cell line MCF-7. Food Chem 126:617–622CrossRefGoogle Scholar
  52. Jang A, Jo C, Kang KS, Lee M (2008) Antimicrobial and human cancer cell cytotoxic effect of synthetic angiotensin-converting enzyme (ACE) inhibitory peptides. Food Chem 107:327–336CrossRefGoogle Scholar
  53. Jang A, Lee M (2005) Purification and identification of angiotensin converting enzyme inhibitory peptides from beef hydrolysates. Meat Sci 69:653–661CrossRefGoogle Scholar
  54. Jauhiainen T, Korpela R (2007) Milk peptides and blood pressure. J Nutr 137:825S–829SGoogle Scholar
  55. Jauhiainen T, Vapaatalo H, Poussa T, Kyrönpalo S, Rasmussen M, Korpela R (2005) Lactobacillus helveticus fermented milk reduces blood pressure in 24-h ambulatory blood pressure measurement. Am J Hypertens 18:1600–1605CrossRefGoogle Scholar
  56. Johanna M (2007) Metalloproteases. In: Poaina J, MacCble AP (eds) Industrial enzymes, structure, function and applications. Springer Publisher, The NetherlandsGoogle Scholar
  57. Jollés P, Caen JP (1991) Parallels between milk clotting and blood clotting: opportunities for milk-derived products. Trends Food Sci Technol 2:42–43CrossRefGoogle Scholar
  58. Jollès P, Levy-Toledano S, Fiat AM, Soria C, Gillesen D, Thomaidis A, Dunn FW, Caen J (1986) Analogy between fibrinogen and casein: effect of an undecapeptide isolated from k-casein on platelet function. Eur J Biochem 158:379–382CrossRefGoogle Scholar
  59. Jung WK, Park PJ, Byun HG, Moon SH, Kim SK (2005) Preparation of Hoki (Johnius belengerii) bone oligophosphopeptide with a high affinity to calcium by carnivorous intestine crude proteinase. Food Chem 91:333–340CrossRefGoogle Scholar
  60. Kazunori K, Tomatsu M, Fuchu H, Sugiyama M, Kawahara S, Yamauchi K et al (2003) Purification and characterization of an angiotensin I-converting enzyme inhibitory peptide derived from porcine troponin C. Anim Sci J 74:53–58CrossRefGoogle Scholar
  61. Khora SS (2013) Marine fish-derived bioactive peptides and proteins for human therapeutics. Int J Pharm Pharm Sci 5:31–37Google Scholar
  62. Kim SK, Byun HG, Park PJ, Shahidi F (2001) Angiotensin I converting enzyme inhibitory peptides purified from bovine skin gelatin hydrolysate. J Agric Food Chem 49:2992–2997CrossRefGoogle Scholar
  63. Kitts DD, Weiler K (2003) Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr Pharm Des 9:1309–1323CrossRefGoogle Scholar
  64. Ko JY, Lee JH, Samarakoon K, Kim JS, Jeon YJ (2013) Purification and determination of two novel antioxidant peptides from flounder fish (Paralichthys olivaceus) using digestive proteases. Food Chem Toxicol 52:113–120CrossRefGoogle Scholar
  65. Korhonen H (2009) Milk-derived bioactive peptides: from science to applications. J Funct Foods 1:177–187CrossRefGoogle Scholar
  66. Korhonen H, Pihlanto A (2003a) Food-derived bioactive peptides-opportunities for designing future foods. Curr Pharm Des 9:1297–1308CrossRefGoogle Scholar
  67. Korhonen H, Pihlanto A (2003b) Bioactive peptides: novel applications for milk proteins. Appl Biotechnol Food Sci Policy 1:133–144Google Scholar
  68. Korhonen H, Pihlanto A (2006) Bioactive peptides: production and functionality. Int Dairy J 16:945–960CrossRefGoogle Scholar
  69. Korhonen H, Pihlanto A (2007) Bioactive peptides from food proteins. In: Hui YH (ed) Handbook of food products manufacturing. Wiley, Hoboken, pp 5–37Google Scholar
  70. Korpela R, Tossavainen O, Korhonen H, Vapaatalo H (2000) Alphalactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sci 66:1535–1543CrossRefGoogle Scholar
  71. Kovacs-Nolan J, Phillips M, Mine Y (2005) Advances in the value of eggs and egg components for human health. J Agric Food Chem 53:8421–8431Google Scholar
  72. Lax R (2010) The future of peptide development in the pharmaceutical industry. Phar Manuf: Int Pept Rev. 2010. Retrieved 10th December, 2012, from http://www.polypeptide.com/assets/002/5188.pdf
  73. Lee SH, Song KB (2009a) Purification of a calcium-binding peptide from hydrolysates of porcine blood plasma protein. J Korean Soc Appl Biol Chem 52:290–294CrossRefGoogle Scholar
  74. Lee SH, Song KB (2009b) Purification of an iron-binding nona-peptide from hydrolysates of porcine blood plasma protein. Process Biochem 44:378–381CrossRefGoogle Scholar
  75. Li-Chan ECY, Powrie WD, Nakai S (1995) The chemistry of eggs and egg products. In: Stadelman WJ, Cotterill OJ (eds) Egg Science and Technology, 4th Ed. Haworth Press, New York, p 105–175Google Scholar
  76. Li G, Le G, Shi Y, Shrestha S (2004) Angiotensin I-convertingenzyme inhibitory peptides derived from food proteins andtheir physiological and pharmacological effects. Nutr Res 24:469–486CrossRefGoogle Scholar
  77. Li Y, Yu J (2014) Research progress in structure-activity relationship of bioactive peptides. J Med Food. doi: 10.1089/jmf.2014.0028 Google Scholar
  78. López-Expósito I, Quiros A, Amigo L, Recio I (2007) Caseinhydrolysates as a source of antimicrobial, antioxydant andantihypertensive peptides. Lait 87:241–249CrossRefGoogle Scholar
  79. López-Expósito I, Recio I (2006) Antibacterial activity of peptides and folding variants from milk proteins. Int Dairy J 16:1294–1305CrossRefGoogle Scholar
  80. López-Fandino R, Recio I, Ramos M (2007) Egg-protein-derived peptides with antihypertensive activity. In: Huopalahti R, López-Fandiño R, Anton M, Schade R (eds) Bioactive egg compounds. Springer, Verlag, pp 199–209CrossRefGoogle Scholar
  81. Lynch PB, Kerry JP (2000) Utilizing diet to incorporate bioactive compounds and improve the nutritional quality of muscle foods. In: Decker E, Faustman C, Lopez-Bote CJ (eds) Antioxidants in muscle foods. Willey, New York, pp 455–480Google Scholar
  82. Maehashi K, Matsuzaki M, Yamamoto Y, Udaki S (1999) Isolation of peptides from an enzymatic hydrolyzate of food proteins and characterization of their taste properties. Biosci Biotechnol Biochem 63:555–559CrossRefGoogle Scholar
  83. Maeno M, Yamamoto N, Takano T (1996) Identification of antihypertensivepeptides from casein hydrolysate produced by a proteinase from Lactobacillushelveticus CP790. J Dairy Sci 73:1316–1321CrossRefGoogle Scholar
  84. Maes W, van Camp J, Vermeirssen V, Hemeryck M, Ketelslegers JM, Schrezenmeier J, van Oostveldt P, Huyghebaert A (2004) Influence of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR) on the release of endothelin-1by endothelial cells. Regul Pept 118:105–109CrossRefGoogle Scholar
  85. Mannheim A, Cheryan M (1990) Continuous hydrolysis of milk protein in a membrane reactor. J Food Sci 55:381–385CrossRefGoogle Scholar
  86. Manso MA, López-Fandino R (2003) Angiotensin I convertingenzyme-inhibitory activity of bovine; ovine; and caprine kappa-casein macropeptides and their tryptic hydrolysates. J Food Prot 66:1686–1692Google Scholar
  87. Martin-Orue C, Henry G, Bouhallab S (1999) Tryptic hydrolysis of k-caseinomacropeptide: control of the enzymatic reaction in acontinuous membrane reactor. Enzym Microbiol Technol 24:173–180CrossRefGoogle Scholar
  88. Masuda O, Nakamura Y, Takano T (1996) Antihypertensive peptides are present in aorta after oral administration of sourmilk containing these peptides to spontaneously hypertensive rats. J Nutr 126:3063–3068Google Scholar
  89. Matar C, LeBlanc JG, Martin L, Perdigo´n G (2003) Biologicallyactive peptides released in fermented milk: role and functions. In: Farnworth ER (ed) Handbook of fermented functional foods, Functional foods and nutraceuticals series. CRC Press, Florida, pp 177–201Google Scholar
  90. McDonagh D, FitzGerald RJ (1998) Production of caseinophosphopeptides (CPPs) from sodium caseinate using a range of commercial protease preparations. Int Dairy J 8:39–45CrossRefGoogle Scholar
  91. McDonald RS, Thornton WH, Marshall RT (1994) A cell culture model to identify biologically active peptides generated by bacterial hydrolysis of casein. J Dairy Sci 77:1167–1175CrossRefGoogle Scholar
  92. Meisel H (1997a) Biochemical properties of regulatory peptides derived from milk proteins. Biopolym 43:119–128CrossRefGoogle Scholar
  93. Meisel H (1997b) Biochemical properties of bioactive peptides derived from milk proteins: Potential nutraceuticals for food and pharmaceutical applications. Livest Prod Sci 50:125–138CrossRefGoogle Scholar
  94. Meisel H (1998) Overview on milk protein–derived peptides. Int Dairy J 8:363–373CrossRefGoogle Scholar
  95. Meisel H (2005) Biochemical properties of peptides encrypted in bovine milk proteins. Curr Med Chem 12:1905–1919CrossRefGoogle Scholar
  96. Meisel H, FitzGerald RJ (2003) Biofunctional peptides from milk proteins: mineral binding and cytomodulatory effects. Curr Pharm Des 9:1289–1295CrossRefGoogle Scholar
  97. Meisel H, Walsh DJ, Murray B, FitzGerald RJ (2006) ACE inhibitory peptides. In: Mine Y, Shahidi F (eds) Nutraceutical proteins and peptides in health and disease. Nutraceutical science and technology, vol 4. Taylor and Francis, Boca Raton, pp 269–315Google Scholar
  98. Meister W, Birch-Hirschfeld E, Koban M, Schilken U, Kunze G, Blasig R (1994) β-casomorphins and related peptides. In: Brantl V, Teschemacher H (eds) Recent developments. VCH, Veinheim, pp 66–72Google Scholar
  99. Mendis E, Rajapakse N, Kim S (2005) Antioxidant properties of a radical scavenging peptide purified from enzymatically prepared fish skin gelatine hydrolysate. J Agric Food Chem 53:581–587CrossRefGoogle Scholar
  100. Mils S, Ross RP, Hill C, Fitzgerald GF, Stanton C (2011) Milk intelligence: mining milk for bioactive substances associated with human heath. Int Dairy J 21:377–401CrossRefGoogle Scholar
  101. Mizushima S, Ohshige K, Watanabe J, Kimura M, Kadowaki T, Nakamura Y, Tochikubo O, Ueshima H (2004) Randomized controlled trial of sour milk on blood pressure inborderline hypertensive men. Am J Hypertens 17:701–706CrossRefGoogle Scholar
  102. Moller NP, Scholz-Ahrens KE, Roos N, Schrezenmeir J (2008) Bioactive peptidesand proteins from foods: indication for health effects. Eur J Nutr 47:171–182CrossRefGoogle Scholar
  103. Mullally MM, Meisel H, FitzGerald RJ (1997) Identification of a novel angiotensin-I-converting enzyme inhibitory peptide corresponding to a tryptic fragment of bovine b-lactoglobulin. FEBS Lett 402:99–101CrossRefGoogle Scholar
  104. Murakami Y, Hirata A (2000) Novel process for enzymatic hydrolysis of proteins in an aqueous two-phase system for the production of peptide mixture. Prep Biochem Biotechnol 30(1):31–37CrossRefGoogle Scholar
  105. Murray BA, FitzGerald RJ (2007) Angiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry, bioactivity and production. Curr Pharm Des 13:773–791CrossRefGoogle Scholar
  106. Nagao JI, Asaduzzaman SM, Aso Y, Okuda KI, Nakayama J, Sonomoto K (2006) Lantibiotics: insight and foresight for new paradigm. J Biosci Bioeng 102:139–149CrossRefGoogle Scholar
  107. Nagaoka S, Futamura Y, Miwa K, Takako A, Yamauchi K, Kanamaru Y, Tadashi K, Kuwata T (2001) Identification of novel hypocholesterolemic peptides derived from bovine milk β-lactoglobulin. Biochem Biophys Res Commun 281:11–17CrossRefGoogle Scholar
  108. Najafian L, Babji AS (2012) A review of fish-derived antioxidant and antimicrobial peptides: their production, assessment and applications. Peptides 33:178–185CrossRefGoogle Scholar
  109. Nakamura Y, Yamamoto N, Sakai K, Okubo A, Yamazaki S, Takano T (1995a) Purification and chracterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci 78:777–783CrossRefGoogle Scholar
  110. Nakamura Y, Yamamoto N, Sakai K, Takano T (1995b) Antihypertensive effect of sourmilk and peptides isolated from it that are inhibitors to Angiotensin I-converting enzyme. J Dairy Sci 78:1253–1257CrossRefGoogle Scholar
  111. Nakashima Y, Arihara K, Sasaki A, Ishikawa S, Itoh M (2002) Antihypertensive activities of peptides derived from porcine skeletal muscle myosin in spontaneously hypertensive rats. J Food Sci 67:434–437CrossRefGoogle Scholar
  112. Narai-Kanayama A, Shikata Y, Hosono M, Aso K (2010) High level production of bioactive di- and tri-tyrosine peptides by protease-catalysed reactions. J Biotechnol 150:343–347CrossRefGoogle Scholar
  113. Nurminen ML, Sipola M, Kaarto H, Pihlanto-Leppala A, Piilola K, Korpela R, Tossavainen O, Korhonen H, Vapaatalo H (2000) Alphalactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sci 66:1535–1543CrossRefGoogle Scholar
  114. Nyberg F, Sanderson K, Glamsta EL (1997) The hemorphins: a new class of opioid peptides derived from the blood protein hemoglobin. Biopolymers 43:147–156CrossRefGoogle Scholar
  115. Okumura T, Yamada R, Nishimura T (2004) Sourness-supressing peptides in cooked pork loins. Biosci Biotechnol Biochem 68:1657–1662CrossRefGoogle Scholar
  116. Ondetti MA, Rubin B, Cushman DW (1977) Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Sci 196:441–444CrossRefGoogle Scholar
  117. Ono T, Takagi Y, Kunishi I (1998) Casein phosphopeptides release from casein micelles by successive digestion with pepsin and trypsin. Biosci Biotechnol Biochem 62:16–21CrossRefGoogle Scholar
  118. Otte J, Shalaby SM, Zakora M, Pripp AH, El-Shabrawy SA (2007) Angiotensin-converting enzyme inhibitory activity of milk protein hydrolysates: effect of substrate, enzyme andtime of hydrolysis. Int Dairy J 17:488–503CrossRefGoogle Scholar
  119. Park KJ, Hyun CK (2002) Antigenotoxic effects of the peptides derived from bovine blood plasma proteins. Enzym Microb Technol 30:633–638CrossRefGoogle Scholar
  120. Perea A, Ugalde U (1996) Continuous hydrolysis of whey proteins in a membrane recycle reactor. Enzym Microb Technol 18:29–34CrossRefGoogle Scholar
  121. Petrillo EW Jr, Ondetti MA (1982) Angiotensin converting enzyme inhibitors: medicinal chemistry and biological actions. Med Res Rev 2:1–41CrossRefGoogle Scholar
  122. Phelan M, Aherne A, FitzGerald RJ, O’Brien NM (2009) Casein-derived bioactive peptides: biological effects, industrial uses, safety aspects and regulatory status. Int Dairy J 19:643–654CrossRefGoogle Scholar
  123. Pihlanto A (2006) Antioxidative peptides derived from milk proteins. Int Dairy J 16:1306–1314CrossRefGoogle Scholar
  124. Pihlanto A, Korhonen H (2003) Bioactive peptides and proteins. Adv Food Nutr Res 47:175–276CrossRefGoogle Scholar
  125. Pihlanto-Leppälä A, Koskinen P, Piilola K, Tupasela T, Korhonen H (2000) Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. J Dairy Res 67:53–64CrossRefGoogle Scholar
  126. Pihlanto-Leppälä A (2001) Bioactive peptides derived from bovine whey proteins: opioid and ACE-inhibitory peptides. Trends Food Sci Technol 11:347–356CrossRefGoogle Scholar
  127. Qian ZY, Jollès P, Migliore-Samour D, Schoentgen F, Fiat AM (1995) Sheep kappa-casein peptides inhibit platelet aggregation. Biochim Biophys Acta 1244:411–417CrossRefGoogle Scholar
  128. Quiros A, Ramos M, Muguerza B, Delgado M, Miguel M, Alexaindre A, Recio I (2007) Identification of novel antihypertensive peptides in milk fermented with Enterococcus faecalis. Int Dairy J 17:33–41CrossRefGoogle Scholar
  129. Regester GO, Smithers GW, Mitchell IR, McIntosh GH, Dionysius DA (1997) Bioactive factors in milk: natural and induced. In: Welch R, Burns D, Davis S, Popay A, Prosser C (eds) Milk composition, production and biotechnology. CAB International, Wallingford, pp 119–132Google Scholar
  130. Rival SG, Boeriu CG, Wichers HJ (2001a) Caseins and casein hydrolysates. 2. Antioxidative properties and relevance to lipoxygenase inhibition. J Agric Food Chem 49:295–302CrossRefGoogle Scholar
  131. Rival SG, Fornaroli S, Boeriu CG, Wichers HJ (2001b) Caseins and casein hydrolysates. Lipoxygenase inhibitory properties. J Agric Food Chem 4:287–294CrossRefGoogle Scholar
  132. Rossini K, Noren CPZ, Cladera-Olivera F, Brandelli A (2009) Casein peptides with inhibitory activity on lipid oxidation in beef homogenates and mechanically deboned poultry meat. LWT Food Sci Technol 42:862–867CrossRefGoogle Scholar
  133. Roufik S, Gauthier SF, Turgeon SL (2006) In vitro digestibility of bioactive peptides derived from bovine β-lactoglobulin. Int Dairy J 16:294–302CrossRefGoogle Scholar
  134. Roy MK, Watanabe Y, Tamai Y (1999) Induction of apoptosis in HL-60 cells by skimmed milk digested with a proteolytic enzyme from the yeast Saccharomyces cerevisiae. J Biosci Bioeng 88:426–432CrossRefGoogle Scholar
  135. Ryan JT, Ross RP, Bolton D, Fitzgerald GF, Stanton C (2011) Bioactive peptides from muscle sources: meat and fish. Nutrients 3:765–791CrossRefGoogle Scholar
  136. Rydlo T, Miltz J, Mor A (2006) Eukaryotic antimicrobial peptides: promises and premises in food safety. J Food Sci 71:R125–R135CrossRefGoogle Scholar
  137. Saïd B, Dominique B (2011) Mineral-binding peptides from food. In: Hettiarachchy NS, Sato K, Marshall MR, Kannan A (eds) Bioactive food proteins and peptides. Applications in human health. CRC Press, Boca Raton, pp 117–130Google Scholar
  138. Saiga A, Okumura T, Makihara T, Katsuta S, Shimizu T, Yamada R, Nishimura T (2003) Angiotensin I-converting enzymes inhibitory peptides in a hydrolyzed chicken breast muscle extract. J Agric Food Chem 51:1740–1745Google Scholar
  139. Saito T (2008) Antihypertensive peptides derived from bovine casein and whey proteins. In: Bösze Z (ed) Advances in experimental medicine and biology: bioactive components of milk, vol 606. Springer, Newyork, pp 295–317CrossRefGoogle Scholar
  140. Sakanaka S, Tachibana Y, Ishihara N, Juneja LR (2005) Antioxidant properties of casein calcium peptides and their effects on lipid oxidation in beef homogenates. J Agric Food Chem 53:464–648CrossRefGoogle Scholar
  141. Sato R, Noguchi T, Naito H (1986) Casein phosphopeptide (CPP) enhances calcium absorption from the ligated segment of rat small intestine. J Nutr Sci Vitaminol 32:67–76CrossRefGoogle Scholar
  142. Seppo L, Jauhiainen T, Poussa T, Korpela R (2003) A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr 77(2):326–330Google Scholar
  143. Shahidi F, Zhong Y (2008) Bioactive peptides. J AOAC Int 91(4):914–931Google Scholar
  144. Sharma S, Singh R, Rana S (2011) Bioactive peptides: a review. Int J Bioautomation 15(4):223–250Google Scholar
  145. Silva SV, Malcata FX (2005) Caseins as source of bioactive peptides. Int Dairy J 15:1–15CrossRefGoogle Scholar
  146. Singh BP, Vij S, Hati S (2014) Functional significance of bioactive peptides derived from soybean. Peptides 54:171–179CrossRefGoogle Scholar
  147. Sipola M, Finckenberg P, Korpela R, Vapaatalo H, Nurminen ML (2002) Effect of long-term intake of milk products on blood pressure in hypertensive rats. J Dairy Res 69:103–111CrossRefGoogle Scholar
  148. Stefano GB, Hartman A, Bilfinger TV, Magazine HI, Liu Y, Casares F, Goligorsky MS (1995) Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation. J Biol Chem 270:30290–30293CrossRefGoogle Scholar
  149. Stiuso P, Caraglia M, De Rosa G, Giordano A (2013) Bioactive peptides in cancer: therapeutic use and delivery strategies. J Amino Acids. doi: 10.1155/2013/568953 Google Scholar
  150. Stuknyte M, De Noni I, Gugliemetti S, Minuzzo M, Mora D (2011) Potential immunomodulatory activity of bovine casein hydrolysates produced after digestion with proteinase of lactic acid bacteria. Int Dairy J 21:763–769CrossRefGoogle Scholar
  151. Su L, Xu G, Shen J, Tuo Y, Zhang X, Jia S, Chen Z, Su X (2010) Anticancer bioactive peptide suppresses human gastric cancer growth through modulation of apoptosis and the cell cycle. Oncol Rep 23(1):3–9Google Scholar
  152. Su X, Dong C, Zhang J, Su L, Wang X, Cui H, Chen Z (2014) Combination therapy of anti-cancer bioactive peptide with Cisplatin decreases chemotherapy dosing and toxicity to improve the quality of life in xenograft nude mice bearing human gastric cancer. Cell Biosci 4:7CrossRefGoogle Scholar
  153. Suarez-Jimenez G-M, Burgos-Hernandez A, Ezquerra-Brauer J-M (2012) Bioactive peptides and depsipeptides with anticancer potential: sources from marine animals. Mar Drugs 10:963–986CrossRefGoogle Scholar
  154. Suetsuna R, Ukeda H, Ochi H (2000) Isolation and characterization of free radical scavenging activities of peptides derived from casein. J Nutr Biochem 11:128–131CrossRefGoogle Scholar
  155. Tauzin J, Miclo L, Gaillard J (2002) Angiotensin I-convertingenzyme inhibitory peptides from tryptic hydrolysate of bovine αs2-casein. FEBS Lett 531:369–374CrossRefGoogle Scholar
  156. Teschemacher H (2003) Opioid receptor ligands derived from food proteins. Curr Pharm Des 9:1331–1344CrossRefGoogle Scholar
  157. Turgeon SL, Gauthier SF (1990) Whey peptide fractions obtained with a two-step ultrafiltration process: production and characterization. J Food Sci 55:106–110CrossRefGoogle Scholar
  158. Urista MC, Fernández ÁR, Rodriguez FR, Cuenca AA, Jurado TA (2011) Review: production and functionality of active peptides from milk. Food Sci Technol Int 17:293–317CrossRefGoogle Scholar
  159. Vermeirssen V, Van Camp J, Devos L, Verstraete W (2003) Release of angiotensin I convertingenzyme (ACE) inhibitory activity during in vitro gastrointestinal digestion: from batch experiment to semicontinuous model. J Agric Food Chem 51:5680–5687CrossRefGoogle Scholar
  160. Vermeirssen V, van Camp J, Verstraete W (2004) Bioavailability of angiotensin I-converting enzyme inhibitory peptides. Br J Nutr 92:357–366CrossRefGoogle Scholar
  161. Visser S, Noorman HJ, Slangeen CJ, Rollema HS (1989) Action of plasmin on bovine β-casein in a membrane reactor. J Dairy Res 56:323–333CrossRefGoogle Scholar
  162. Wang B, Li L, Chi CF, Ma JH, Luo HY, Xu YF (2013) Purification and characterisation of a novel antioxidant peptide derived from blue mussel (Mytilus edulis) protein hydrolysate. Food Chem 138:1713–1719CrossRefGoogle Scholar
  163. Wang LL, Xiong YI (2008) Inhibition of oxidant-induced biochemical changes of pork myofibrillar protein by hydrolyzed potato protein. J Food Sci 73:C482–C487CrossRefGoogle Scholar
  164. Won-Kyo J, Pyo-Jam P, Hee-Guk B, Sung-Hoon M, Se-Kwon K (2005) Preparation of Hoki (Johnius belengeri), bone oligophosphopeptide with a high affinity to calcium by carnivorous intestine crude proteinase. Food Chem 91:333–340Google Scholar
  165. Yamamoto M, Maeno M, Takano T (1999) Purification and characterization of an antihypertensive peptide from a yogurt-like product fermented by Lactobacillus helveticus CPN4. J Dairy Sci 82:1388–1393CrossRefGoogle Scholar
  166. Yamamoto N, Akino A, Takano T (1994) Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. J Dairy Sci 77:917–922CrossRefGoogle Scholar
  167. Yamamoto N, Ejiri M, Mizuno S (2003) Biogenic peptides and their potential use. Curr Pharm Des 9:1345–1355CrossRefGoogle Scholar
  168. Yamazaki Y, Maekawa K (1980) Synthesis of a peptide with delicious taste. Agric Biol Chem 44:93–97CrossRefGoogle Scholar
  169. Yoshikawa M, Sasaki R, Chiba H (1981) Effect of chemical phosphorylation of bovine casein components on the properties related to casein micelle formation. Agric Biol Chem 45:909–914Google Scholar
  170. Yu L, Yang L, An W, Su X (2014) Anticancer bioactive peptide-3 inhibits human gastric cancer growth by suppressing gastric cancer stem cells. J Cell Biochem 115(4):697–711CrossRefGoogle Scholar
  171. Yu PL, van der Linden DS, Sugiarto H, Anderson RC (2010) Antimicrobial peptides isolated from the blood of farm animals. Anim Prod Sci 50:660–669Google Scholar
  172. Zambrowicz A, Timmer M, Eckert E, Trziszka T (2013) Evaluation of the ACE-inhibitory activity of egg-white proteins degraded with pepsin. Pol J Food Nutr Sci 63(2):103–108Google Scholar
  173. Zhang L, Zhou JLK (2010) Chelating and radical scavenging activities of soy protein hydrolysates prepared from microbial proteases and their effect on meat lipid peroxidation. Bioresour Technol 101:2084–2089CrossRefGoogle Scholar
  174. Zhang X, Beynen A (1993) Lowering effect of dietary milk-whey protein v. casein on plasma and liver cholesterol concentrations in rats. Br J Nutr 70:139–146CrossRefGoogle Scholar
  175. Zhao Q, Girreau I, Sannier F, Piot JM (1997) Opioid peptides derived from hemoglobin: hemorphins. Biopolymers 43:75–98CrossRefGoogle Scholar
  176. Zhao QY, Piot JM, Gautier V, Cottenceau G (1996) Isolation and characterization of a bacterial growth-stimulating peptide from a peptic bovine haemoglobin hydrolysate. Appl Microb Biotechnol 45:778–784CrossRefGoogle Scholar
  177. Zimecki M, Kruzel ML (2007) Milk-derived proteins and peptides of potential therapeutic and nutritive value. J Exp Ther Oncol 6:89–106Google Scholar

Copyright information

© Association of Food Scientists & Technologists (India) 2015

Authors and Affiliations

  1. 1.Division of Livestock Products Technology, Faculty of Veterinary Sciences and Animal HusbandrySher-e-Kashmir University of Agricultural Sciences and Technology of JammuJammuIndia
  2. 2.Division of Biotechnology, Faculty of Veterinary Sciences and Animal HusbandrySher-e-Kashmir University of Agricultural Sciences and Technology of KashmirShuhamaIndia

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