Journal of Food Science and Technology

, Volume 50, Issue 3, pp 415–428

Nutrigenomics research: a review

Review-Invited article

Abstract

The excitement about nutrigenomics comes from a growing awareness of the potential for modifications of food or diet to support health and reduce the risk of diet-related diseases. It is an emerging field that tends to unfold the role of nutrition on gene expression which brings together the science of bioinformatics, nutrition, molecular biology, genomics, epidemiology, and molecular medicine. The present review focuses on nutrigenomics research and to find out India’s status with respect to other countries. It covers the general overview of nutrigenomics, its associated diseases, and the role of SNP in gene alteration, diet supplementation and public awareness. It is understood that with the increasing changes in the food habits and life styles, people are becoming more prone to diet related disorders. Therefore there is an urgent need to boost more research in this field to help people in understanding the relationship between diet and health, and to ensure that everyone benefits from the genomic revolution.

Keywords

Nutrigenomics Diet-gene interaction Nutrition Food supplement Diabetes Obesity 

References

  1. Acharya T, Kumar NK, Muthuswamy V, Daar AS, Singer PA (2004) Harnessing genomics to improve health in India—An executive course to support genomics policy. Health Research Policy and Systems 2:1–13CrossRefGoogle Scholar
  2. Adiga MNS, Chandy S, Ramaswamy G, Appaji L, Krishnamoorthy L (2008) Homocysteine, vitamin B12 and folate status in pediatric acute lymphoblastic leukemia. Indian J Pediatr 7:235–238CrossRefGoogle Scholar
  3. Afman L, Muller M (2006) Nutrigenomics: from molecular nutrition to prevention of disease. J Am Diet Assoc 106(4):569–576CrossRefGoogle Scholar
  4. Aswini YB, Varun S (2010) Genetics in public health: rarely explored. Indian Journal of Human Genetics 16:47–54CrossRefGoogle Scholar
  5. Bhatt SN, Sharma AD (2011) Nutrigenomics: a non—conventional therapy. International Journal of Pharmaceutical Sciences Review and Research 8(2):100–105Google Scholar
  6. Coudron TA, Yocum GD, Brandt SL (2006) Nutrigenomics: a case study in the measurement of insect response to nutritional quality. Entomol Exp Appl 121:1–14CrossRefGoogle Scholar
  7. Dhaka V, Gulia N, Ahlawat KS, Khatkar BS (2011) Trans fats—sources, health risks and alternative approach—A review. J Food Sci Technol 48(5):534–541CrossRefGoogle Scholar
  8. Dhara R, Dhar P, Ghosh M (2011) Dietary effects of diacylglycerol rich mustard oil on lipid profile of normocholesterolemic and hypercholesterolemic rats. J Food Sci Technol. doi:10.1007/s13197-011-0388-y
  9. Dhillon VS, Shahid M, Husain SA (2007) Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men. Molecular Human Reproduction 13(4):213–222CrossRefGoogle Scholar
  10. Ghodke Y, Chopra A, Shintre P, Puranik A, Joshi K, Patwardhan B (2011) Profiling single nucleotide polymorphisms (SNPs) across intracellular folate metabolic pathway in healthy Indians. Indian J Med Res 133:274–279Google Scholar
  11. Ghosh D (2009) Future perspectives of nutrigenomics foods: benefits vs. risks. Indian Journal of Biochemistry & Biophysics 46:31–36Google Scholar
  12. Ghosh D (2010) Personalised food: how personal is it? Genes Nutr 5:51–53CrossRefGoogle Scholar
  13. Ghosh K, Gorakshakar A (2010) Integration of modern genetic knowledge and technology into public health in India. Indian Journal of Human Genetics 16:45–46CrossRefGoogle Scholar
  14. Ghoshal S, Pasham S, Odom DB, Furr HC, McGrane MM (2003) Vitamin A depletion is associated with low phosphoenolpyruvate carboxykinase mRNA levels during late fetal development and at birth in mice. J Nutr 133:2131–eGoogle Scholar
  15. Gobard B, Hurlimann T (2009) Nutrigenomics for global health: ethical challenges for underserved populations. Current Pharmacogenomics and Personalized Medicine 7(3):205–14CrossRefGoogle Scholar
  16. Godbole K, Deshmukh U, Yajnik C (2009) Nutri-genetic determinants of neural tube defects in India. Indian Pediatrics 46:467–475Google Scholar
  17. Gomase VS, Tripathi AK, Tagore S (2009) Genomics: new aspect of cancer research. International Journal of Systems Biology 1(1):01–19Google Scholar
  18. Gopalan C (1992) The contribution of nutrition research to the control of under nutrition: the Indian experience. Annu Rev Nutr 12:1–17CrossRefGoogle Scholar
  19. Hosomi R (2011) Effect of combination of dietary fish protein and fish oil on lipid metabolism in Rats. J Food Sci Technol. doi:10.1007/s13197-011-0343-y
  20. Hossain P, Kawar B, Nahas ME et al (2007) Obesity and diabetics in the developing world—A growing challenge. N Engl J Med 356:213–215CrossRefGoogle Scholar
  21. Hyman M (2006) Book on Ultra-metabolism: the simple plan for automatic weight loss. Atria Books, New York, p 24Google Scholar
  22. Jeyakumar SM et al (2005) Vitamin A supplementation induces adipose tissue loss through apoptosis in lean but not in obese rats of the WNIN/Ob strain. Journal of Molecular Endocrinology 35:391–398CrossRefGoogle Scholar
  23. Kamra A, Kalavapudi S, Sudhakaran TR et al (2005) Exfoliated colonic epithelial cells: surrogate targets for evaluation of bioactive food components in cancer prevention. J Nutr 135(11):2719–2722Google Scholar
  24. Kandaswamy R (2011) Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79). Diabetes Technol Ther 13(1):33–42CrossRefGoogle Scholar
  25. Kaput J et al (2007) Application of nutrigenomic concepts to type 2 diabetes mellitus. Nutr Metab Cardiovas 17:89–103CrossRefGoogle Scholar
  26. Kaur N, Chugh V, Gupta AK (2012) Essential fatty acids as functional components of foods- a review. J Food Sci Technol. doi:10.1007/s13197-012-0677-0
  27. Kishore K, Sinha SK, Kumar R, Gupta NC, Dubey N, Sachdev A (2006) Isolation and characterization of microsomal ω-6-desaturase gene (fad2-1) from soybean. Indian J Exp Biol 45:390–397Google Scholar
  28. Kore KB, Pathak AK, Gadekar YP (2008) Nutrigenomics: emerging face of molecular nutrition to improve animal health and production. Vet world 1(9):285–286Google Scholar
  29. Krishnaswamy K (2008) Developing and implementing dietary guidelines in India. Asia Pac J Clin Nutr 17:66–69Google Scholar
  30. Kumar A, Singh RP (2009) Obesity: prevalence, manifestations and dietary patterns—A review. J Food Sci Technol 46(4):287–299Google Scholar
  31. Kumar PA et al (2009) Delay of diabetic cataract in rats by the antiglycating potential of cumin through modulation of α-crystallin chaperone activity. Journal Nutr Biochem 20(7):553–562CrossRefGoogle Scholar
  32. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D (2008) Nutrigenomics analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics 9:239–251CrossRefGoogle Scholar
  33. Majeed M, Prakash L (2006) Nutraceuticals and the Future of Medical Science. http://www.drmajeed.com/articles/2006NutraceuticalsAndTheFuture.pdf. Accessed 15 February 2011
  34. Melvyn A Sydney-Smith Nutrition Medicine: Genes, Nutrition & Health. www.nutritionmedicine.org/Files/Genes_Nutrition.ppt
  35. Menon B, Harinarayan CV, Raj MN, Vemuri S, Himabindu G, Afsana TK (2010) Prevalence of low dietary calcium intake in patients with epilepsy: a study from South India. Neurol India 58:209–212CrossRefGoogle Scholar
  36. Merched AJ, Serhan CN, Chan L (2011) Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis. J Nutrigenet Nutrigenomics 4:12–24CrossRefGoogle Scholar
  37. Mitra et al (2005) Nutrigenomics: a new frontier. http://www.apiindia.org/images/stories/pdf/medicine_update_2005/chapter_182.pdf. Accessed 25 January 2011
  38. Mohan V, Sandeep S, Deepa R, Shah B, Varghese C (2007a) Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res 125:217–230Google Scholar
  39. Mohan V, Sudha V, Radhika G, Radha V, Rema M, Deepa R (2007b) Gene-environment interactions and the diabetes epidemic in India. Forum Nutr 60:118–126CrossRefGoogle Scholar
  40. Moloney F et al (2007) Antidiabetic effects of cis-9, trans-11–conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes 56:574–582CrossRefGoogle Scholar
  41. Mrudula T et al (2007) Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochem Bioph Res Co 361(2):528–532CrossRefGoogle Scholar
  42. Munshi A, Duvvuri VS (2008) Nutrigenomics: looking to DNA for nutrition advice. Indian J Biotechnol 7:32–40Google Scholar
  43. Murray HM, Lall SP, Rajaselvam R et al (2010) A nutrigenomic analysis of intestinal response to partial soybean meal replacement in diets for juvenile Atlantic halibut, Hippoglossus hippoglossus, L. Aquaculture 298:282–293CrossRefGoogle Scholar
  44. Nair S, Pillai MR (2005) Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers. Oral Dis 11:350–359CrossRefGoogle Scholar
  45. Naushad SM, Radha A, Devi R (2010) Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India. J Perinat Med 38:63–69CrossRefGoogle Scholar
  46. Pathak P, Srivastava S, Grover S (2000) Development of food products based on millets, legumes and fenugreek seeds and their suitability in the diabetic diet. Int J Food Sci Nutr 51(5):409–414CrossRefGoogle Scholar
  47. Prasad SSSV, Kumar SSJ, Kumar PU, Qadri SS, Vajreswari A (2010) Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue. Lipids Health Dis 9(111):1–5Google Scholar
  48. Raj M, Sundaram KR, Paul M, Deepa AS, Kumar RK (2007) Obesity in Indian children: time trends and relationship with hypertension. Natl Med J India 20(6):288–293Google Scholar
  49. Ramachandran A (2006) The Indian diabetes prevention programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP1). Diabetologia 49:289–297CrossRefGoogle Scholar
  50. Raman C, Manohar SL, Xavier N, Krishnan M (2007) Expression of silk gene in response to P-soyatose (hydrolyzed soy bean protein) supplementation in the fifth instar male larvae of Bombyx Mori. Journal of Cell and Molecular Biology 6(2):163–174Google Scholar
  51. Ramesha C, Kumari SS, Anuradha CM, Lakshmi H, Kumar CS (2010) Nutrigenomic analysis of mulberry silkworm (Bombyx mori L.) strains using Polymerase Chain Reaction - Simple Sequence Repeats (PCR-SSR). International Journal for Biotechnology and Molecular Biology Research 1(7):92–100Google Scholar
  52. Rao S (2001) Nutritional status of Indian population. J Bioscience 26(4):481–489CrossRefGoogle Scholar
  53. Rastogi T, Reddy KS, Vaz M et al (2004) Diet and risk of ischemic heart disease in India. Am J Clin Nutr 79:582–592Google Scholar
  54. Rojas J et al (2011) AMPK as target for intervention in childhood and adolescent obesity. Journal of Obesity. doi:10.1155/2011/252817
  55. Roy S, Bagchi D, Bagchi M, Khanna S, Sen CK, Rink C, Phillips C (2004) Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Gene Expression 11:251–262CrossRefGoogle Scholar
  56. Sharma M, Majumdar PK (2009) Occupational life style diseases: an emerging issue. Indian J Occup Environ Med 13(3):109–112CrossRefGoogle Scholar
  57. Sharma R, Singh RB (2010) Bioactive foods and nutraceutical supplementation criteria in cardiovascular protection. Open Nutraceuticals J 3:141–153CrossRefGoogle Scholar
  58. Sherwood D (2006) Nutrigenomics: public concerns and commercial interests. Agro Food Ind Hi Tech 17(4):56–57Google Scholar
  59. Shetty PS (2002) Nutrition transition in India. Public Health Nutr 5(1A):175–172CrossRefGoogle Scholar
  60. Siddique RA, Tandon M, Ambwani T, Rai SN, Atreja SK (2009) Nutrigenomics: nutrient-gene interactions. Food Rev Int 25(4):326–345CrossRefGoogle Scholar
  61. Singh K, Jaiswal D (2011) Human male infertility: a complex multifactorial phenotype. Reprod Sci 18(5):418–425CrossRefGoogle Scholar
  62. Singh RB, Niaz MA, Ghosh S (1994) Effect on central obesity and associated disturbances of low-energy, fruit- and vegetable-enriched prudent diet in North Indians. Postgrad Med J 70:895–900CrossRefGoogle Scholar
  63. Singh RB, Dubnov G et al (2002) Effect of an Indo- Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean diet heart study): a randomized single-blind trial. Lancet 360:1455–1461CrossRefGoogle Scholar
  64. Sinha R et al (2003) Cancer risk and diet in india. J Postgrad Med 49:222–228Google Scholar
  65. Sivasankaran S (2010) The cardio-protective diet. Indian J Med Res 132(5):608–616Google Scholar
  66. Srinivasarao P et al (1997) Lipid composition and fatty acid profiles of myelin and synaprosomal membranes of rat brain in response to the consumption of different fats. J Nutr Biochem 8(9):527–534CrossRefGoogle Scholar
  67. Thompkinson DK, Bhavana V, Kanika P (2012) Dietary approaches for management of cardio-vascular health- a review. J Food Sci Technol. doi:10.1007/s13197-012-0661-8
  68. Trehan N (2006) Cardiovascular disease trends in India. http://www.chroniccareindia.org/documents/Naresh_Trehan.pdf
  69. Vijayakumar MV et al (2005) The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. Brit J Pharmacol 146:41–48CrossRefGoogle Scholar
  70. Vijayakumar MV et al (2010) Hypolipidemic effect of fenugreek seeds is mediated through inhibition of fat accumulation and upregulation of LDL receptor. Obesity 18(4):667–674CrossRefGoogle Scholar
  71. WHO Report: The impact of chronic disease in India. http://www.who.int/chp/chronic_disease_report/media/india.pdf
  72. Wilde JD et al (2009) An 8-week high-fat diet induces obesity and insulin resistance with small changes in the muscle transcriptome of C57BL/6J mice. J Nutrigenet Nutrigenomics 2:280–291CrossRefGoogle Scholar
  73. Yusuf MA, Sarin NB (2006) Antioxidant value addition in human diets: genetic transformation of Brassica juncea with γ-TMT gene for increased α-tocopherol content. Transgenic Res 16:109–113CrossRefGoogle Scholar
  74. Zduńczyk Z, Pareek CS (2009) Application of nutrigenomics tools in animal feeding and nutritional research. J Anim Feed Sci 18:3–16Google Scholar
  75. Zeisel Steven H (2011) Nutritional genomics: defining the dietary requirement and effects of choline. J Nutr 141:531–534CrossRefGoogle Scholar

Copyright information

© Association of Food Scientists & Technologists (India) 2012

Authors and Affiliations

  1. 1.NISCAIR (National Institute of Science Communication and Information Resources)New DelhiIndia

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