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Gingival Angiosarcoma: A Case Report and Clinicopathologic Review of 32 Cases of Primary Gingival Angiosarcoma

Abstract

Angiosarcoma is a malignant neoplasm of mesenchymal origin arising from vascular endothelium and most commonly involves extremities. Gingival angiosarcoma is a rare sporadic occurring tumor. We report a case of primary angiosarcoma of gingiva along with a review of 31 cases of primary gingival angiosarcoma reported in literature till 2018. A 30-year-old lady presented with recurrent gingival swelling over central mandible. She had no palpable cervical lymphadenopathy. She underwent central marginal mandibulectomy. Final histological analysis with immunohistochemistry was suggestive of the angiosarcoma of the gingiva. She is 50 months postoperative and doing well.

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References

  1. 1.

    Fanburg-Smith JC, Furlong MA, Childers EL (2003) Oral and salivary gland angiosarcoma: a clinicopathologic study of 29 cases. Mod Pathol 16(3):263–271

  2. 2.

    Uchiyama Y, Murakami S, Kishino M, Furukawa S (2009) A case report of primary gingival angiosarcoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108(6):e17–e21

  3. 3.

    Nagata M, Yoshitake Y, Nakayama H, Yoshida R, Kawahara K, Nakagawa Y, Shinohara M (2014) Angiosarcoma of the oral cavity: a clinicopathological study and a review of the literature. Int J Oral Maxillofac Surg 43(8):917–923

  4. 4.

    Henny FA (1949) Angiosarcoma of the maxilla in a 3-month-old infant; report of case. J Oral Surg (Chic) 7(3):250–252

  5. 5.

    Blake H, Blake FS (1956) Angiosarcoma; report of a case. Oral Surg Oral Med Oral Pathol 9(8):821–825

  6. 6.

    Quinn JH, McConnell HA Jr, Leonard GL (1970) Multifocal angiosarcoma of the gingiva: report of case. J Oral Surg 28(3):215–217

  7. 7.

    Albright CR, Shelton DW, Vatral JJ, Hobin FC (1970 Dec) Angiosarcoma of the gingiva: report of case. J Oral Surg. 28(12):913–917

  8. 8.

    Wesley RK, Mintz SM, Wertheimer FW (1975) Primary malignant hemangioendothelioma of the gingiva: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol 39(1):103–112

  9. 9.

    Piscioli F, Leonardi E, Scappini P, Cristofolini M (1986) Primary angiosarcoma of the gingiva. Case report with immunohistochemical study. Am J Dermatopathol 8(5):430–435

  10. 10.

    Carr RJ, Green DM (1986) Oral presentation of disseminated angiosarcoma. Br J Oral Maxillofac Surg 24(4):277–285

  11. 11.

    Kashima K, Igakura Y, Komura M, Hamada M, Arima R, Sakoda S (1994) Three gingival tumors derived from vascular endothelial cells: a case of hemangioendothelioma and two cases of angiosarcoma. Nihon Koku Shuyo Gakkaishi 6:251–261

  12. 12.

    Margiotta V, Florena AM, Giuliana G (1994) Primary angiosarcoma of the alveolar mucosa in a haemodialysis patient: case report and discussion. J Oral Pathol Med 23(9):429–431

  13. 13.

    Muñoz M, Monje F, del Hoyo JA, Martín-Granizo R (1998 Apr 1) Oral angiosarcoma misdiagnosed as a pyogenic granuloma. J Oral Maxillofac Surg 56(4):488–491

  14. 14.

    Abdullah BH, Yahya HI, Talabani NA, Alash NI, Mirza KB (2000) Gingival and cutaneous angiosarcoma. J Oral Pathol Med 29(8):410–412

  15. 15.

    Loudon JA, Billy ML, DeYoung BR, Allen CM (2000) Angiosarcoma of the mandible: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 89(4):471–476

  16. 16.

    Favia G, Muzio LL, Serpico R, Maiorano E (2002) Angiosarcoma of the head and neck with intra-oral presentation. A clinico-pathological study of four cases. Oral Oncol 38(8):757–762

  17. 17.

    Penner C, Grist W, Müller S (2002) Epithelioid angiosarcoma presenting in the gingiva of an adolescent. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 94(2):205–216

  18. 18.

    Florescu M, Simionescu C, Margaritescu C, Georgescu CV (2005) Gingival angiosarcoma: histopathologic and immunohistochemical study. Romanian J Morphol Embryol 46(1):57–61

  19. 19.

    Driemel O, Müller-Richter UD, Hakim SG, Bauer R, Berndt A, Kleinheinz J, Reichert TE, Kosmehl H (2008) Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma. Head Face Med 4(1):17

  20. 20.

    Mücke T, Deppe H, Wolff KD, Kesting MR (2010) Gingival angiosarcoma mimicking necrotizing gingivitis. Int J Oral Maxillofac Surg 39(8):827–830

  21. 21.

    Gordon-Nunez MA, Lopes MF, Maia AP, Galvão HC (2010) Intraoral epithelioid hemangioendothelioma: a case report and review of the literature. Med Oral Patolog Oral Cir Bucal 15(2):e340–e346

  22. 22.

    Terada T (2011) Angiosarcoma of the oral cavity. Head Neck Pathol 5(1):67–70

  23. 23.

    Suzuki G, Ogo E, Tanoue R, Tanaka N, Watanabe Y, Abe T, Iwamoto O, Kusukawa J, Hayabuchi N (2011) Primary gingival angiosarcoma successfully treated by radiotherapy with concurrent intra-arterial chemotherapy. Int J Clin Oncol 16(4):439–443

  24. 24.

    Sumida T, Murase R, Fujita Y, Ishikawa A, Hamakawa H (2012) Epulis-like gingival angiosarcoma of the mandible: a case report. Int J Clin Exp Pathol 5(8):830–833

  25. 25.

    Aditya A, Lele S (2012) A nodular growth on maxillary gingiva. Indian J Dent Res 23(1):116–119

  26. 26.

    Sachdeva SK, Dutta S, Rout P (2015) Angiosarcoma of mandible: An uncommon clinical entity. Int J Appl Basic Med Res 5(2):142

  27. 27.

    Hunasgi S, Koneru A, Vanishree M, Manvikar V (2016) Angiosarcoma of anterior mandibular gingiva showing recurrence–a case report with immunohistochemistry. J Clin Diagn Res 10(7):ZD01–ZD04

  28. 28.

    Chamberland F, Maurina T, Degano-Valmary S, Spicarolen T, Chaigneau L (2016) Angiosarcoma: a case report of gingival disease with both palatine tonsils localization. Rare Tumors 8(3):113–117

  29. 29.

    Aljadeff L, Fisher CA, Wolf SL, Byrd KM, Curtis W, Ward BB, Munz SM, Fullen DR, McHugh JB, Danciu TE (2016) Red exophytic mass of the maxillary anterior gingiva. Oral Surg Oral Med Oral Pathol Oral Radiol 122(4):379–384

  30. 30.

    Hartanto FK, Lau SH (2018) A case report of Angiosarcoma of maxillary gingiva: histopathology aspects. Sci Dent J 2(2):77–83

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Correspondence to Syed Nusrath.

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Nusrath, S., Goel, V., Raju, K. et al. Gingival Angiosarcoma: A Case Report and Clinicopathologic Review of 32 Cases of Primary Gingival Angiosarcoma. Indian J Surg Oncol (2020). https://doi.org/10.1007/s13193-020-01032-7

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