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Impact of Length of Distal Margin on Outcomes Following Sphincter Preserving Surgery for Middle and Lower Third Rectal Cancers

  • Rahul Bhamre
  • Abhishek Mitra
  • Anup Tamankar
  • Ashwin Desouza
  • Avanish SaklaniEmail author
Original Article

Abstract

Outcomes of sphincter preserving surgery for distal rectal cancers improve with clear circumferential resection and distal resection margin. However, the extent of distal resection margin after a complete mesorectal excision is often a cause for debate. We evaluated the outcome of middle and lower third rectal cancer patients undergoing sphincter preservation with variable distal resection margin at our center. Patients with biopsy-proven rectal adenocarcinoma within 10 cm from anal verge undergoing sphincter preserving resections were included. Patients with positive circumferential resection margin were excluded. Patients were divided into three groups based on the extent of distal resection margin (< 6 mm, 6–10 mm, > 10 mm) and oncological outcomes were compared. The median age of 242 patients was 50 years and 44 (18.2%) were high-grade tumors. Preoperative chemoradiation was used in 185 (75.2%) patients. Median distal resection margin was 20 mm. Patients in < 10 mm group had a significantly higher proportion of lower third (68.3% vs 39.8%, p = 0.004) and chemoradiation-treated tumors (85.4 vs 74.6%, p = 0.001). A significantly higher percentage required an intersphincteric resection in the < 10 mm group (53.7% vs 14.4%, p = 0.0001). Significantly higher percentage tumors were pT3 in > 10 mm group (45.3% vs. 31.7%) (p = 0.05). The median follow-up was 23 months. There was no difference in the overall, loco-regional, and distant recurrence rates between the three groups. A subcentimeter distal resection margin does not influence loco-regional or distant recurrence rates following sphincter preserving surgery for middle and lower third rectal adenocarcinoma.

Keywords

Adenocarcinoma Rectum Margin Survival 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Indian Association of Surgical Oncology 2019

Authors and Affiliations

  • Rahul Bhamre
    • 1
  • Abhishek Mitra
    • 2
  • Anup Tamankar
    • 1
  • Ashwin Desouza
    • 1
  • Avanish Saklani
    • 1
    Email author
  1. 1.Colorectal Service, Department of Surgical oncologyTata Memorial HospitalMumbaiIndia
  2. 2.GI and HPB Service, Department of Surgical OncologyNational Cancer InstituteNagpurIndia

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