Advertisement

A Rare Case of Metastasis to the Mandible from the Thyroid Gland: a Case Report and Literature Review

  • Shirish PatilEmail author
  • Deepak Janardhan
  • Sandeep Suresh
  • Shaji Thomas
Case Report
First Online:

Case Report

A 56-year-old female with multiple comorbidities presented with a swelling in the lower jaw (Figs. 1 and 2). On examination, it was a hard 6 × 5 cm swelling in the right mandible, 3 cm from the symphyses and posteriorly involving the angle of the mandible. The oral cavity did not show any evidence of disease. Also, a 3 × 2 cm nodule in the right lobe and 1 × 1 cm nodule in the left lobe of the thyroid were palpated without cervical lymphadenopathy. Laryngoscopy revealed both the cords to be mobile. Fine-needle aspiration cytology revealed a Bethedsa 1, i.e., few follicular cells. A trucut biopsy was undertaken from the mandibular swelling, which revealed a metastatic lesion from the thyroid which was positive for thyroglobulin and CKT. A bone scan of Tc-99 was done as part of the metastatic evaluation and showed an increased uptake in the right body of the mandible. Contrast-enhanced CT neck showed a 2.8 × 2.9 × 1.6 calcific nodule in the right lobe of the thyroid, a...
This is a preview of subscription content, log in to check access.

Notes

References

  1. 1.
    Zachariades N (1989) Neoplasms metastatic to the mouth, jaws and surrounding tissues. J Craniomaxillofac Surg 17:283–290CrossRefGoogle Scholar
  2. 2.
    Irani S (2016) Metastasis to the oral soft tissues: a review of 412 cases. J Int Soc Prev Community Dent 6:393–401CrossRefGoogle Scholar
  3. 3.
    Antunes AA, Antunes AP (2008) Gnathic bone metastasis: a retrospective study of 10 cases. Braz J Otorhinolaryngol 74:561–565CrossRefGoogle Scholar
  4. 4.
    Irani S (2017) Metastasis to the jawbones: a review of 453 cases. J Int Soc Prevent Communit Dent 7:71–81CrossRefGoogle Scholar
  5. 5.
    Batson OV (1995) The function of the vertebral veins and their role in the spread of metastases 1940. Clin Orthop Relat Res:4–9Google Scholar
  6. 6.
    Kumar GS, Manjunatha BS (2013) Metastatic tumors to the jaws and oral cavity. J Oral Maxillofac Pathol 17:71–75CrossRefGoogle Scholar
  7. 7.
    Wu K, Hou SM, Huang TS et al (2008) Thyroid carcinoma with bone metastases: a prognostic factor study. Clin Med Oncol 2:129–113Google Scholar
  8. 8.
    Chantrain CF, Feron O, Marbaix E, DeClerck YA (2008) Bone marrow microenvironment and tumor progression. Cancer Microenviron 1:23–35CrossRefGoogle Scholar
  9. 9.
    Chen HL, Chang WH, Shih SC, Pang KK, Bair MJ (2008) Trismus and trigeminal neuralgia in one patient with colon cancer. J Natl Med Assoc 100:740–742CrossRefGoogle Scholar
  10. 10.
    Burt RK, Sharfman WH, Karp BI, Wilson WH (1992) Mental neuropathy (numb chin syndrome). A harbinger of tumor progression or relapse. Cancer 70:877–881CrossRefGoogle Scholar
  11. 11.
    Germain MA, Marandas P, Leridant AM, Domenge C, Julieron M, Schlumberger M, Mamelle G (1998) Métastase isolée d’un cancer thyroïdien. Mandibulectomie et reconstruction par greffon libre péronéen. Rev Stomatol Chir Maxillofac 98(6):371–374Google Scholar
  12. 12.
    Tickoo SK, Pittas AG, Adler M, Fazzari M, Larson SM, Robbins RJ, Rosai J (2000) Bone metastases from thyroid carcinoma: a histopathologic study with clinical correlates. Arch Pathol Lab Med 124:1440–1447Google Scholar
  13. 13.
    Toubert ME, Hindie E, Rampin L, Al-Nahhas A, Rubello D (2007) Distant metastases of differentiated thyroid cancer: diagnosis, treatmentand outcome. Nucl Med Rev Cent East Eur 10:106–109Google Scholar
  14. 14.
    Fanchiang JK, Lin JD, Huang MJ, Shih HN (1998) Papillary and follicular thyroid carcinomas with bone metastases: a series of 39 cases during a period of 18 years. Changgeng Yi Xue Za Zhi 21:377–382Google Scholar
  15. 15.
    Pingel, Kimberly & Kalogirou, Eleni-Marina & G. Koutlas, Ioannis & Tosios, Konstantinos. (2013). Mandibular metastasis of a papillary thyroid carcinoma, tall cell variant. Case report and review of the literature. Hellenic Archives of Oral & Maxillofacial Surgery 3. 143–152Google Scholar
  16. 16.
    Bingol UA, Çinar C, Çetinkale O (February 2015) Mandibular metastases of papillary thyroid carcinoma treated by Hemimandibulectomy and costochondral rib graft. Plastic and Reconstructive Surgery – Global Open 3(2):e305CrossRefGoogle Scholar
  17. 17.
    Anajar S, Hassnaoui J, Rouadi S, Abada R, Roubal M, Mahtar M (2017) Mandibular metastasis revealed papillary thyroid carcinoma: rare case. Int J Surg Case Rep 37:130–133.  https://doi.org/10.1016/j.ijscr.2017.05.001 CrossRefGoogle Scholar
  18. 18.
    Das R, Kumar M, Sharma JD, Krishnatreya M, Chakraborty PS, Kataki AC (2014) Papillary thyroid carcinoma presenting with mandibular metastasis: an unusual presentation. Clin Cancer Investig J 3:426–428CrossRefGoogle Scholar
  19. 19.
    Osguthorpe JD, Bratton JR (1982) Occult thyroid carcinoma appearing as a single mandibular metastasis. Otolaryngol Head Neck Surg 90(5):674–675CrossRefGoogle Scholar
  20. 20.
    Gerhards F, Kuffner HD, Wagner W (1998) Pathological fractures of the mandible: a review of the etiology and treatment. Int J Oral Maxillofac Surg 27(3):186 190CrossRefGoogle Scholar
  21. 21.
    Ismail SB, Abraham MT, Zaini ZB, Yaacob HB, Zain RB (2009) Metastatic follicular thyroid carcinoma to the mandible: a case report. Cases J 2:6533CrossRefGoogle Scholar
  22. 22.
    Wexler JA (2011) Approach to the thyroid cancer patient with bone metastases. JClin Endocrinol Metab 96:2296–2307CrossRefGoogle Scholar
  23. 23.
    Stojadinovic A, Shoup M, Ghossein RA, Nissan A, Brennan MF, Shah JP, Shaha AR (2002) The role of operations for distantly metastatic well-differentiated thyroid carcinoma. Surgery 131:636–643CrossRefGoogle Scholar

Copyright information

© Indian Association of Surgical Oncology 2019

Authors and Affiliations

  1. 1.Head and Neck OncosurgeryRegional Cancer CentreTrivandrumIndia
  2. 2.Dept. of Surgical OncologyRegional Cancer CentreTrivandrumIndia
  3. 3.Assistant prof , Head and Neck Oncosurgery, Regional Cancer CentreTrivandrumIndia
  4. 4.FellowHead and Neck Oncosurgery, Regional Cancer CentreTrivandrumIndia

Personalised recommendations

Cite article

Buy options