Cytologic Clues to the Diagnosis of Lymphoepithelioma-Like Carcinoma of Parotid Gland with Possible Therapeutic Implications
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Lymphoepithelioma-like carcinoma (LELC) is a rare histological variant, comprising less than 1% of all salivary gland neoplasms . The World Health Organization (WHO) has defined it as “a poorly differentiated squamous cell carcinoma or histologically undifferentiated carcinoma accompanied by a prominent reactive lympho-plasmacytic infiltrate, morphologically similar to nasopharyngeal carcinoma.” The importance of distinguishing LELC from other poorly differentiated carcinoma lies in the fact that despite being poorly differentiated, they have a better prognosis and are radiosensitive.
LELC has been described in nasopharynx, larynx, tonsils, salivary glands, lung, thymus, stomach, duodenum, breast, renal pelvis, urinary bladder, uterine cervix, endometrium, ovary, vulva, and vagina with female predominance . LELC has been associated with Epstein Barr Virus (EBV) in tumors derived from foregut and rarely in LELCs arising from other sites .
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The authors declare that they have no conflict of interest.
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