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Diagnostic Accuracy of Frozen Section and Its Influence on Intraoperative Management of Indeterminate Epithelial Ovarian Tumors

  • Nyengidiki T. Kennedy
  • Ajit SebastianEmail author
  • Dhanya S. Thomas
  • Anitha Thomas
  • Mayank Gupta
  • Ramani Manoj Kumar
  • Abraham Peedicayil
Original Article
  • 1 Downloads

Abstract

The objective of this study is to determine the diagnostic accuracy of frozen section in detecting epithelial ovarian tumor histological types and its effect on management. A retrospective review was done of all patients who had an intraoperative frozen section for an indeterminate ovarian tumor over a six-year period. The reference standard was final histology. The validity indices for frozen section in diagnosing benign, borderline, and malignant lesions were determined. One hundred thirty-five intraoperative frozen section–diagnosed epithelial ovarian tumors were reviewed. The mean age was 44.9 ± 14.2 years, the median parity was 2, and 57% (77/135) of patients were post-menopausal. The commonest histological subtype was mucinous 48.1% (65/135) on frozen section and 46.7% (63/135) on final histology. The overall concordance rate of frozen section to final histology was 81.5% (ƙ = 0.719, p = 0.0001). The accuracy, sensitivity, specificity, and positive predictive value of frozen section to diagnose benign lesions were 86.7%, 85.7%, 97.2%, and 79.2% respectively. In borderline tumors, the diagnostic test characteristics were 88.1%, 81.2%, 90.3%, and 72.2%. For malignant lesions, these values were 88.1%, 77.8%, 95.1%, and 91.3% respectively. The odds ratios for frozen section being correct were 40.9 (95% CI 14.8–113.5) for benign lesions, 40.3 (95% CI 13.4–121.3) for borderline tumors, and 67.4 (95% CI 20.5–222.0) for malignancy. Over-treatment or under-treatment occurred in 19.3% of patients. Intraoperative frozen section is useful in situations where the nature of the ovarian tumor is uncertain. However, borderline ovarian tumors are more likely to be over-diagnosed. About a fifth of patients received inappropriate treatments based on the frozen section report.

Keywords

Diagnostic test Ovarian neoplasm Frozen section India 

Notes

Acknowledgments

Dr. Rachel G Chandy for encouragement and logistic support.

Contributions

Nyengidiki T Kennedy: Conceptualization, methodology, analysis, data curation, original draft

Ajit Sebastian: Conceptualization, validation, data curation, writing and review, visualization

Dhanya S Thomas: Software, writing and review

Anitha Thomas: Software, writing and review

Mayank Gupta: Software, writing and review

Ramani M Kumar: Methodology, validation, writing and review

Abraham Peedicayil: Conceptualization, methodology, original draft, review and editing, supervision

Compliance with Ethical Standards

Permission for the study was obtained from the Institutional Review board (IRB).

Conflict of Interest

The authors declare that they have no conflict of interest.

Disclaimers

None

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Copyright information

© Indian Association of Surgical Oncology 2019

Authors and Affiliations

  • Nyengidiki T. Kennedy
    • 1
  • Ajit Sebastian
    • 2
    Email author
  • Dhanya S. Thomas
    • 2
  • Anitha Thomas
    • 2
  • Mayank Gupta
    • 3
  • Ramani Manoj Kumar
    • 3
  • Abraham Peedicayil
    • 2
  1. 1.Department of Obstetrics & GynaecologyUniversity of Port Harcourt Teaching HospitalPort HarcourtNigeria
  2. 2.Department of Gynecologic OncologyChristian Medical College & HospitalVelloreIndia
  3. 3.Department of PathologyChristian Medical College & HospitalVelloreIndia

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