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Indian Journal of Surgical Oncology

, Volume 6, Issue 4, pp 390–398 | Cite as

Obesity and Cancer: Concepts and Challenges

  • Daniel F. ArgoloEmail author
  • Neil M. Iyengar
  • Clifford A. Hudis
Review Article

Abstract

The rates of overweight and obesity are increasing worldwide in both developed and developing countries. Obesity is a major public health problem as it is associated with many diseases, including diabetes, hypertension, dyslipidemia, atherosclerosis, and some types of cancer. Breast cancer is a malignancy in which both the risk of development and the prognosis are negatively impacted by the obese state. The precise mechanisms pathophysiologically linking obesity and cancer are still under investigation. The biological basis for these associations includes both systemic and local tissue effects and white adipose tissue inflammation appears to be a critical component. A comprehensive understanding of the mechanisms linking obesity, inflammation and cancer may provide an opportunity for the development of strategies to attenuate the negative impact of obesity.

Keywords

Obesity Cancer Breast cancer Risk factors Adipose tissue Inflammation 

Notes

Compliance with Ethical Standards

Conflict of Interest

All authors declare that they have no conflict of interest.

Funding/Grant Support

2014 Conquer Cancer Foundation of ASCO LIFe Award (to Daniel F. Argolo).

Breast Cancer Research Foundation (to Clifford A. Hudis and Neil M. Iyengar).

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Copyright information

© Indian Association of Surgical Oncology 2015

Authors and Affiliations

  • Daniel F. Argolo
    • 1
    • 3
    Email author
  • Neil M. Iyengar
    • 1
    • 2
  • Clifford A. Hudis
    • 1
    • 2
  1. 1.Memorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Weill Cornell Medical CollegeNew YorkUSA
  3. 3.CLION – CAM GroupSalvadorBrazil

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