Indian Journal of Surgical Oncology

, Volume 2, Issue 3, pp 212–214 | Cite as

A Rare Cause of Massive Lymphadenopathy

  • H. RajaEmail author
  • S. G. Subramanyam
  • Sridar Govindaraj
  • M. K. Babu
Case Report


Rosai Dorfman Disease is a rare disease presenting mainly as painless enlargement of cervical lymph nodes. It is a benign disorder showing unique histological features characterized by reactive proliferation of sinus histiocytes. In 40% of cases, extranodal sites may be involved. The condition has to be differentiated from certain types of B cell lymphoma showing similar features. We report here a 17 year old male presenting with nodal and extranodal involvement of Rosai Dorfman Disease.


Rosai dorfman disease Emperipolesis S – 100 protein 


Source of funding


Conflict of interest



  1. 1.
    Perry BP, Gregg CM, Myers S, Lilly S, Mann KP, Prieto V (1998) Rosai-Dorfman disease (extranodal sinus histiocytosis) in a patient with HIV. Ear Nose Throat J 77(10):855–858PubMedGoogle Scholar
  2. 2.
    Kruse AL, Gengler C, Gratz KW, Obwegeser JA (2010) Extranodal manifestation of Rosai – Dorfman disease without involvement of lymphnodes. J Craniofac Surg 21(6):1733–1736PubMedCrossRefGoogle Scholar
  3. 3.
    Kong YY, Kong JC, Shi DR, Lu HF, Zhu XZ, Wang J, Chen ZW (2007) Utaneous Rosai-Dorfman disease: a clinical and Histopathologic study of 25 cases in China. Am J Surg Pathol 31(3):341–350PubMedCrossRefGoogle Scholar
  4. 4.
    Z'Graggen WJ, Sturzenegger M, Mariani L, Keserue B, Kappeler A, Vajtai I (2006) Isolated Rosai – Dorfman disease of intracranial menninges. Pathol Res Pract 202(3):165–170PubMedCrossRefGoogle Scholar
  5. 5.
    Kademani D, Patel SG, Prasad ML, Huvos AG, Shah JP (1993) Intraoral presentation of Rosai-Dorfman disease: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93(6):699–704CrossRefGoogle Scholar
  6. 6.
    Krishnan A, Nassar A, Nieh PT (2005) Rosai-Dorfman disease presenting as extranodal renal mass. Urology 66(6):1319PubMedCrossRefGoogle Scholar
  7. 7.
    Chu P (1992) LeBoit PE Histologic features of cutaneous sinus histiocytosis (Rosai-Dorfman disease): study of cases both with and without systemic involvement. J Cutan Pathol 19(3):201–206PubMedCrossRefGoogle Scholar
  8. 8.
    Lopes LF, Bacchi MM, Coelho KI, Filho AA (2003) Bacchi CE Emperipolesis in a case of B-cell lymphoma: a rare phenomenon outside of Rosai-Dorfman disease. Ann Diagn Pathol 7(5):310–313PubMedCrossRefGoogle Scholar

Copyright information

© Indian Association of Surgical Oncology 2011

Authors and Affiliations

  • H. Raja
    • 1
    Email author
  • S. G. Subramanyam
    • 2
  • Sridar Govindaraj
    • 2
  • M. K. Babu
    • 3
  1. 1.Department of SurgerySt. John’s Medical College HospitalBangaloreIndia
  2. 2.Department of SurgerySt. John’s Medical College HospitalBangaloreIndia
  3. 3.Department of PathologySt. John’s Medical College HospitalBangaloreIndia

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