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  • Charlotte Goldfine
  • Mark Neavyn
Articles You Might Have Missed
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Article #1: Pryce G, Baker D. Antidote to cannabinoid intoxication: the CB1 receptor inverse agonist, AM251, reverses hypothermic effects of the CB1 receptor agonist, CB-113, in mice. Br J of Pharmacology 2017;174:3709.  https://doi.org/10.1111/bph.13973

Background:

Over the past decade, synthetic cannabinoid receptor agonists (SCRAs, known colloquially as “K2” or “spice”) have been more widely used as recreational drugs. These synthetic agonists work mainly on the CB-1 cannabinoid receptor found primarily in the neocortex, hypothalamus, basal ganglia, hippocampus, and cerebellum. While most cannabis exposures require minimal interventions, SCRAs can cause serious adverse effects and have been associated with deaths. Use of CB-1 receptor antagonists for SCRA toxicity may be effective.

Research Question:

Can cannabimimetic effects be reversed by a CB1 receptor antagonist/inverse agonist?

Methods:

Adult mice were given a dose of a synthetic CB1 receptor agonist (CB-13;...

Keywords

Synthetic cannabinoids Paraquat Complement Acute lung injury Mercury 

Notes

Compliance with Ethical Standards

Conflicts of Interest

None.

Copyright information

© American College of Medical Toxicology 2018

Authors and Affiliations

  1. 1.Division of Medical Toxicology and Department of Emergency MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA

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