Naltrexone: Not Just for Opioids Anymore
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Naltrexone is a semi-synthetic opioid with competitive antagonist activity at mu opioid receptors. Its efficacy has been demonstrated in the treatment of alcohol and opioid dependence, but adherence to daily dosing has been recognized as a factor limiting long-term effectiveness. Recently, a long-acting injectable formulation of naltrexone has received FDA-approval for treating alcohol and opioid dependence. This article reviews the pharmacology of naltrexone, the current evidence supporting the use of extended-release naltrexone, and the clinical challenges in the induction of patients to this medication.
KeywordsNaltrexone Addiction Toxicology Alcohol dependence Opioid dependence
- 1.Substance Abuse and Mental Health Services Administration. Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings. Rockville, MD 2014.Google Scholar
- 5.Weerts EM, Kim YK, Wand GS, Dannals RF, Lee JS, Frost JJ, et al. Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. Neuropsychopharmacol Off Pub Am College of Neuropsychopharmacol. 2008;33(3):653–65.CrossRefGoogle Scholar
- 26.Hartung DM, McCarty D, Fu R, Wiest K, Chalk M, Gastfriend DR. Extended-release naltrexone for alcohol and opioid dependence: a meta-analysis of healthcare utilization studies. J Subst Abuse Treat. 2014.Google Scholar
- 27.Curatolo C, Trinh M. Challenges in the perioperative management of the patient receiving extended-release naltrexone. A & A Ccase Rrep. 2014;3(11):142–4.Google Scholar