Journal of Medical Toxicology

, Volume 10, Issue 4, pp 399–401

Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement

  • Annette M. Lopez
  • Joshua Kornegay
  • Robert G. Hendrickson
Observation

References

  1. 1.
    Roy S, Rink C, Khanna S, Phillips C, Bagchi D, Bagchi M et al (2004) Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Gene Expr 11(5–6):251–262PubMedGoogle Scholar
  2. 2.
    Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ (2002) Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem 238(1–2):89–103PubMedCrossRefGoogle Scholar
  3. 3.
    Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D (2005) Bioefficacy of a novel calcium-potassium salt of (−)-hydroxycitric acid. Mutat Res 579(1–2):149–162PubMedCrossRefGoogle Scholar
  4. 4.
    Preuss HG, Bagchi D, Bagchi M, Rao CV, Dey DK, Satyanarayana S (2004) Effects of a natural extract of (−)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 6(3):171–180PubMedCrossRefGoogle Scholar
  5. 5.
    Onakpoya I, Hung SK, Perry R, Wider B, Ernst E (2011) The use of Garcinia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta-analysis of randomized clinical trials. J Obes, Article ID 509038, 9 pages. doi:10.1155/2011/509038
  6. 6.
    Heymsfield S, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C (1998) Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 280:1596–1600PubMedCrossRefGoogle Scholar
  7. 7.
    Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM (2003) The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM 96(9):635–642PubMedCrossRefGoogle Scholar
  8. 8.
    Sternbach H (1991) The serotonin syndrome. Am J Psychiatry 148:705–713PubMedGoogle Scholar

Copyright information

© American College of Medical Toxicology 2014

Authors and Affiliations

  • Annette M. Lopez
    • 1
    • 2
  • Joshua Kornegay
    • 1
  • Robert G. Hendrickson
    • 1
    • 2
  1. 1.Department of Emergency MedicineOregon Health and Sciences UniversityPortlandUSA
  2. 2.Oregon Poison CenterPortlandUSA

Personalised recommendations