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Journal of Medical Toxicology

, Volume 6, Issue 1, pp 77–78 | Cite as

Imidacloprid Poisoning—Newer Insecticide and Fatal Toxicity

  • Ramya Iyyadurai
  • Ige Abraham George
  • John Victor Peter
The Poison Pen

Keywords

Imidacloprid Neurological Dysfunction Multiple Organ Dysfunction Syndrome Severe Metabolic Acidosis Epinephrine Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

To the Editor,

There is a constant search for new and potent insecticides nontoxic to humans. We describe fatal toxicity with one such insecticide considered relatively safe.

A 34-year-old male from rural India was brought following the deliberate consumption of imidacloprid in a suicide attempt. At presentation, he was comatose with dilated nonreacting pupils, diaphoretic, and cyanosed. His blood pressure was unrecordable, and his heart rate was 50/min. Following intubation and stabilization of hemodynamics with crystalloids, a gastric lavage was performed. Subsequently, he was referred to our hospital. On arrival, 2 h later, he continued to be unconscious with fixed dilated pupils. His blood pressure was 130/80 mmHg and pulse rate 86/min.

Following transfer to intensive care, he required epinephrine infusion to maintain blood pressure. Deterioration of renal function was noted from the second day with progressive oligoanuria (peak creatinine 6.9 mg/dl) and severe metabolic acidosis necessitating dialysis. Creatinine phosphokinase levels of 67,980 U/L (reference < 170 U/L) suggested rhabdomyolysis. Hospital stay was further complicated by the development of liver dysfunction, ventilator-associated pneumonia, and refractory septic shock. Despite appropriate supportive therapy, he succumbed on day 12.

Neonicotinoids, agonists at the nicotinic acetylcholine receptors (nAChRs), induce neuromuscular paralysis. The high selectivity for nAChRs (particularly the a4b2 subtype) in insects compared with mammals results in their favorable toxicological profile [1, 2]. Imidacloprid, the commonest neonicotinoid used in South Asia, was recently reported to have a 0% case fatality in a series of 68 patients presenting with poisoning [3]. Despite their safety profile, other publications have described rhabdomyolysis [4], neuropsychiatric manifestations [4], ventricular fibrillation [5], and deaths with imidacloprid [5, 6, 7].

This patient manifested neurological dysfunction and rhabdomyolysis. The initial neurological dysfunction, probably due to central nicotinic stimulation, was compounded by ischemic and metabolic encephalopathy. Renal injury was perpetuated by rhabdomyolysis, hypotension, and toxin. Progressive deterioration and eventual demise was due to multiple organ dysfunction syndrome and not the toxin per se. Serum imidacloprid level would have helped elucidate causality, but was unavailable. This report of imidacloprid toxicity sensitizes clinicians to an emerging cause of poisoning and highlights the need for a careful review of its toxicity profile.

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

References

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Copyright information

© American College of Medical Toxicology 2010

Authors and Affiliations

  • Ramya Iyyadurai
    • 2
  • Ige Abraham George
    • 2
  • John Victor Peter
    • 2
    • 1
  1. 1.Medical Intensive Care UnitChristian Medical College and HospitalVelloreIndia
  2. 2.Department of Medicine and Critical CareChristian Medical College and HospitalVelloreIndia

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