Nutritional recommendations for individuals with Flammer syndrome
The Flammer syndrome (FS) describes the phenotype of people with a predisposition for an altered reaction of the blood vessels to stimuli like coldness or emotional stress. The question whether such people should be treated is often discussed. On the one hand, most of these subjects are healthy; on the other hand, FS seems to predispose to certain eye diseases such as normal tension glaucoma or retinitis pigmentosa or systemic diseases such as multiple sclerosis or tinnitus. A compromise between doing nothing and a drug treatment is the adaption of nutrition. But what do we mean by healthy food consumption for subjects with FS? The adaption of nutrition depends on the health condition. Whereas patients with e.g. a metabolic syndrome should reduce their calorie intake, this can be counterproductive for subjects with FS, as most subjects with FS have already a low body mass index (BMI) and the lower the BMI the stronger the FS symptoms. Accordingly, while fasting is healthy e.g. for subjects with metabolic syndrome, fasting can even dangerously aggravate the vascular dysregulation, as it has been nicely demonstrated by the loss of retinal vascular regulation during fasting. To give another example, while reducing salt intake is recommended for subjects with systemic hypertensions, such a salt restriction can aggravate systemic hypotension and thereby indirectly also the vascular regulation in subjects with FS. This clearly demonstrates that such a preventive adaption of nutrition needs to be personalized.
KeywordsPreventive Personalized Flammer syndrome Oxidative stress Antioxidative nutrition
The eyes, like all other organs of the body, depend upon nutrients, vitamins and minerals, to maintain their health and proper function. Thus, the way an individual eats affects the health of their eyes. Many individuals, including those with the Flammer syndrome (FS) [1, 2] are aware that their nutritional habits and lifestyle affect the health of their eyes, [3, 4] but may not know what they should be eating to support their eye health. The term ‘Flammer Syndrome’ refers to a clinical entity comprising a complex of clinical features caused mainly by dysregulation of the blood supply which has previously been called vascular dysregulation [2, 5, 6]. With an increase in allergies , heightened concerns over health , increased scrutiny of chemical additives and growing environmental concerns [9, 10], there is more attention being paid to nutrition and lifestyle today than perhaps ever before. Ophthalmologists are therefore often confronted with questions from people with the FS regarding nutrition. This may be partly due to the fact that people with the FS are often dissatisfied with conventional forms of treatment because they do not tolerate drugs in normal dosages as well as other people due to a different expression of ATP-binding cassette (ABC) transport proteins , or because the drug has produced adverse effects, or simply because they want to actively do something themselves for their eye health by changing their nutrition and lifestyle. In Europe, we are slowly going to where the Eastern culture has been for hundreds of years back to the idea that food is medicine and that we cannot disassociate our health with what we eat. As ophthalmologists, we are doing no harm to the patient by providing them with additional information on nutrition and lifestyle for the following reasons: it is cheap, well accepted by the patient as it has a natural source and supports the FS patient with their subjective symptoms with some first studies showing objective improvements in measures such as increased retinal venous pressure [5, 6], decreased systemic oxidative stress or improvements in peripheral blood flow [12, 13, 14]. It is important to note, however, that nutritional recommendations for people with FS are quite different than those with a metabolic syndrome. Accordingly, while fasting is healthy e.g. for subjects with metabolic syndrome, fasting can even dangerously aggravate the vascular dysregulation. Similarly, while reducing salt intake is recommended for subjects with systemic hypertensions, such a salt restriction can aggravate systemic hypotension  and thereby indirectly also the vascular regulation in subjects with FS . This demonstrates that such preventive adaptation of nutrition needs to be personalized .
This article provides an overview of beverages and foods with potential antioxidative effect, as well as lifestyle measures an individual can take to support the FS.
General background chemistry
Tea flavonoids are scavengers of the superoxide anion and nitric oxide  which plays an important role in the pathogenesis of glaucomatous damage as well as of hydrogen peroxide which plays a role in UV-induced oxidative damage. Tea flavonoids inhibit the formation of lipid peroxyl radical species and thus inhibit LDL peroxidation . Tea polyphenols may have protective effects against cancer , although studies are controversial.
The polyphenolic content in red wine is higher than white wine , explaining why red wine exerts a stronger antioxidant capacity than white wines . Polyphenols in wine lower the susceptibility of LDL lipids to oxidation  and improve endothelial dysfunction [35, 36] impairment which leads to damage to vascular cells and the surrounding tissue. Wine polyphenols affect endothelial function by stimulating the production of endothelial nitric oxide synthase (eNOS) and thus increasing the production of nitric oxide (NO) which induces vasodilation . In addition, wine polyphenols inhibit the synthesis of the potent vasoconstrictor endothelin-1 . In experimental models, flavonoids in wine prevented the initiation of atherosclerotic plaque development [38, 39]. Extracellular levels of vascular endothelial growth factor (VEGF) were reduced by resveratrol , a polyphenol found in grapes and wine.
The Ginkgo biloba tree is one of the oldest trees found in fossils dating back 270 million years ago . This tree is indigenous to China, Japan and Korea where it currently exists in areas of higher altitude , which are well drained, and adapts relatively well to different ecological conditions. The leaves and the fruits rich in flavone glycosides and terpenoids of ginkgo [43, 44] have been used for medical purposes for thousands of years by the Chinese.
Borage (Borago officinalis), also known as star flower, belongs to the flowering plant family Boraginaceae. This plant is native to the Mediterranean region but has a high resistance to cold climates and grows well in wet soils with good drainage and exposure to sunlight . The beautiful violet-to-purple-coloured leaves of this plant are edible, and culinary borage oil can be extracted from the seeds of this plant. Traditionally, borage was cultivated for culinary as well as medicinal uses [64, 65, 66, 67]. The leaves of borage contain polyphenols with antioxidative effect  whereas the seeds are a rich source of gamma-linolenic acid (GLA) , with anti-inflammatory effects. Borage leaves are used as an anticonvulsant , bronchodilator and vasodilator . In a recent study, borage tea was shown to decrease increased retinal venous pressure in people with FS. This effect is most likely due to the calcium-antagonizing side effects of this plant .
Fruits and vegetables
Diets rich in fruits and vegetables may reduce oxidative stress and inflammation [71, 72]. These beneficial effects are due to their high polyphenol content which may vary from season to season , and on their natural stage of fruit ripening . Fruits and berries blue in colour are a rich source of anthocyanosides with free radical scavenging properties . These fruits exert their beneficial properties even if taken in the dried form [76, 77].
Omega 3 fatty acids
Omega-3 fatty acids also known as polyunsaturated fatty acids are considered essential fatty acids. Omega-3 fatty acids are found in fish, such as salmon, tuna and halibut, other seafoods including algae and krill and flaxseed oil . Omega-3 fatty acid prevents development of intracranial atherosclerosis , reduce inflammation [80, 81], lower blood pressure , improve endothelial vascular function  and modulate intracellular calcium ion release and thereby the stabilization of circulation .
The cacao tree or ‘Theobroma cacao’ is native to the deep tropical regions of Central and South America . The cacao beans are a rich source of polyphenolic flavonoids whose antioxidant capacity has been shown to be higher than that of wine or green tea . The amount of cacao is double as high in dark chocolate in comparison to milk chocolate . Besides, the milk in milk-chocolate interferes with the absorption of cacao polyphenols . Consumption of cocoa-rich food, such as dark chocolate, is associated with a reduced risk for vascular disease [90, 91, 92, 93, 94]. This is due to the action of flavan-3-ols which augment endothelial NOS and thereby enhance the production of nitric oxide (NO), thereby improving endothelium-dependant vasorelaxation . Cacao decreases blood pressure [96, 97], increases insulin sensitivity , increases HDL cholesterol concentrations  and reduces blood platelet stickiness and clotting [91, 92].
Magnesium can be found in a variety of foods such as seeds (chia, flax and pumpkin), avocados, tofu, nuts, legumes including beans and peas, whole grains and leafy greens. Magnesium is a physiological calcium channel blocker that partially inhibits the effect of endothelin-1  and improves blood flow . A dosage of 10–20 mmol daily is recommended for adults to improve the regulation of blood flow [13, 99]. For the patient, it is important to note that the different forms of magnesium contain different amounts of magnesium, and in case they are uncertain of the correct daily dosage of the particular magnesium supplement, they should refer to their pharmacist. Forms of magnesium that dissolve well in liquid are more completely absorbed in the gut than less soluble forms .
Since this amount cannot be consumed solely by nutrition, we recommend the intake of magnesium in supplements. Unfortunately, it is difficult to compare the bioavailability of various forms of magnesium because different experimental methods and forms or qualities of magnesium supplements are used in various studies. One experimental study comparing the bioavailability of four inorganic and six organic mineral salts of magnesium suggested that although all ten organic and inorganic Mg salts were equally efficient in restoring blood Mg levels in plasma and red blood cells in rats, magnesium gluconate exhibited the highest magnesium retention and absorption values in the ten studied groups .
Finally, it is of note that although side effects are minimal, one potential side effect of magnesium supplementation is diarrhoea due to the osmotic activity of unabsorbed salts in the intestine and colon and the stimulation of gastric motility . In case of diarrhoea, we recommend to take the supplement in small amounts throughout the day, perhaps together with some banana or bread.
There is increasing interest in the antioxidant compounds of herbs and spices not only because they retard the oxidative degradation of lipids [103, 104] but also because they improve the flavour of food. Spices including curcumin, safran, ginger, cinnamon and pepper contain polyphenolic flavonoids with antioxidative activity. During cooking, heat brings forward mutagenic epoxides, hydroperoxides and unsaturated aldehydes, which are carcinogenic . Heating changes the nature of the membranes because of decomposition of the cell walls allowing antioxidant molecules more access to the free radical, thus enhancing antioxidant activity of certain spices during the heating process .
Unfortunately, we still do not conclusively know whether nutritional sources of antioxidants can benefit people with FS. Growing evidence suggests, however, that oxidative stress resulting from FS may increase the risk of diseases such as glaucoma [99, 113, 114]. It is therefore worthwhile to summarize the present knowledge as nutritional and lifestyle changes with potential to reduce oxidative stress may benefit people with FS.
ABC, ATP-binding cassette; C, catechin; EC, epicatechin; EGC, epigallocatechin; eNOS, endothelial nitric oxide synthase; FS, Flammer syndrome; GLA, gamma-linolenic acid; HDL, high-density lipoprotein; IOP, intraocular pressure; LDL, low-density lipoprotein; MCP, 3-methyl-1,2-cyclopentanedione; NO, nitric oxide; TFs, theaflavins; TGs, thearubigins; UV, ultraviolet.
Compliance with ethical standards
No funding was received for this article.
Conflict of interest
The authors declare that they have no conflict of interest.
- 2.Mozaffarieh M, Fontana Gasio P, Schötzau A, Orgül S, Flammer J, Kräuchi K. Thermal discomfort with cold extremities in relation to age, gender, and body mass index in a random sample of a Swiss urban population. Popul Health Metr. 2010;8:17. doi: 10.1186/1478-7954-8-17.PubMedPubMedCentralCrossRefGoogle Scholar
- 10.von Holst C, Robouch P, Bellorini S, González de la Huebra MJ, Ezerskis Z. The work of the European Union Reference Laboratory for Food Additives (EURL) and its support for the authorisation process of feed additives in the European Union: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016;33(1):66–77.Google Scholar
- 18.Mozaffarieh M, Flammer J. Ocular blood flow and glaucomatous optic neuropathy. Springer; 2009.Google Scholar
- 19.Flammer J, Mozaffarieh M, Bebie H. Redox reactions. In: Basic sciences in ophthalmology: physics and chemistry. Springer Science & Business Media; 2013. pp 160–167.Google Scholar
- 26.Niedzwiecki A, Roomi MW, Kalinovsky T, Rath M. Anticancer efficacy of polyphenols and their combinations. Nutrients. 2016;8(9). doi: 10.3390/nu8090552.
- 35.López-Sepúlveda R, Gómez-Guzmán M, Zarzuelo MJ, Romero M, Sánchez M, Quintela AM, Galindo P, O’Valle F, Tamargo J, Pérez-Vizcaíno F, Duarte J, Jiménez R. Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase. Clin Sci (Lond). 2011;120(8):321–33.CrossRefGoogle Scholar
- 36.López-Sepúlveda R, Jiménez R, Romero M, Zarzuelo MJ, Sánchez M, Gómez-Guzmán M, Vargas F, O’Valle F, Zarzuelo A, Pérez-Vizcaíno F, Duarte J. Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats. Hypertension. 2008;51(4):1088–95.PubMedCrossRefGoogle Scholar
- 38.Scoditti E, Calabriso N, Massaro M, Pellegrino M, Storelli C, Martines G, De Caterina R, Carluccio MA. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys. 2012;527(2):81–9.PubMedCrossRefGoogle Scholar
- 39.Hayek T, Fuhrman B, Vaya J, Rosenblat M, Belinky P, Coleman R, Elis A, Aviram M. Reduced progression of atherosclerosis in apolipoprotein E–deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol. 1997;17(11):2744–52.PubMedCrossRefGoogle Scholar
- 44.Xie H, Wang JR, Yau LF, Liu Y, Liu L, Han QB, Zhao Z, Jiang ZH. Quantitative analysis of the flavonoid glycosides and terpene trilactones in the extract of Ginkgo biloba and evaluation of their inhibitory activity towards fibril formation of β-amyloid peptide. Molecules. 2014;19(4):4466–78.PubMedCrossRefGoogle Scholar
- 56.Pierre S, Lesnik P, Moreau M, Bonello L, Droy-Lefaix MT, Sennoune S, Duran MJ, Pressley TA, Sampol J, Chapman J, Maixent JM. The standardized Ginkgo biloba extract Egb-761 protects vascular endothelium exposed to oxidized low density lipoproteins. Cell Mol Biol (Noisy-le-grand). 2008;54(Suppl):OL1032–42.Google Scholar
- 74.Rodríguez JC, Gómez D, Pacetti D, Núñez O, Gagliardi R, Frega NG, Ojeda ML, Loizzo MR, Tundis R, Lucci P. Effects of the fruit ripening stage on antioxidant capacity, total phenolics, and polyphenolic composition of crude palm oil from interspecific hybrid Elaeis oleifera× Elaeis guineensis. J Agric Food Chem. 2016;64(4):852–9.PubMedCrossRefGoogle Scholar
- 76.Oszmiański J, Lachowicz S. Effect of the production of dried fruits and juice from chokeberry (Aronia melanocarpa L.) on the content and antioxidative activity of bioactive compounds. Molecules. 2016;21(8). doi: 10.3390/molecules21081098.
- 80.Harvey LD, Yin Y, Attarwala IY, Begum G, Deng J, Yan HQ, Dixon CE, Sun D. Administration of DHA reduces endoplasmic reticulum stress-associated inflammation and alters microglial or macrophage activation in traumatic brain injury. ASN Neuro. 2015;7(6). doi: 10.1177/1759091415618969.
- 83.Casanova MA, Medeiros F, Trindade M, Cohen C, Oigman W, Neves MF. Omega-3 fatty acids supplementation improves endothelial function and arterial stiffness in hypertensive patients with hypertriglyceridemia and high cardiovascular risk. J Am Soc Hypertens. 2016; doi: 10.1016/j.jash.2016.10.004.PubMedGoogle Scholar
- 88.da Silva Medeiros N, Koslowsky Marder R, Farias Wohlenberg M, Funchal C, Dani C. Total phenolic content and antioxidant activity of different types of chocolate, milk, semisweet, dark, and soy, in cerebral cortex, hippocampus, and cerebellum of Wistar rats. Biochem Res Int. 2015;2015:294659. doi: 10.1155/2015/294659.PubMedPubMedCentralCrossRefGoogle Scholar
- 90.Flammer AJ, Sudano I, Wolfrum M, Thomas R, Enseleit F, Périat D, Kaiser P, Hirt A, Hermann M, Serafini M, Lévêques A, Lüscher TF, Ruschitzka F, Noll G, Corti R. Cardiovascular effects of flavanol-rich chocolate in patients with heart failure. Eur Heart J. 2012;33(17):2172–80.PubMedCrossRefGoogle Scholar
- 93.Heiss C, Sansone R, Karimi H, Krabbe M, Schuler D, Rodriguez-Mateos A, Kraemer T, Cortese-Krott MM, Kuhnle GG, Spencer JP, Schroeter H, Merx MW, Kelm M. Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Age (Dordr). 2015;37(3):9794. doi: 10.1007/s11357-015-9794-9.CrossRefGoogle Scholar
- 94.Rassaf T, Rammos C, Hendgen-Cotta UB, Heiss C, Kleophas W, Dellanna F, Floege J, Hetzel GR, Kelm M. Vasculoprotective effects of dietary cocoa flavanols in patients on hemodialysis: a double–blind, randomized, placebo–controlled trial. Clini J Am Soc Nephrol. 2016;11(1):108–18.CrossRefGoogle Scholar
- 95.Karim M, McCormick K, Kappagoda CT. Effects of cocoa extracts on endothelium-dependent relaxation. Journal Nutr. 2000;130(8S Suppl):2105S–8S.Google Scholar
- 98.Martínez-López S, Sarriá B, Sierra-Cinos JL, Goya L, Mateos R, Bravo L. Realistic intake of a flavanol-rich soluble cocoa product increases HDL-cholesterol without inducing anthropometric changes in healthy and moderately hypercholesterolemic subjects. Food Funct. 2014;5(2):364–74.PubMedCrossRefGoogle Scholar