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Nuclear Medicine and Molecular Imaging

, Volume 53, Issue 6, pp 423–431 | Cite as

Safety Profile and Therapeutic Efficacy of One Cycle of Lu177-PSMA in End-Stage Metastatic Castration-Resistant Prostate Cancer Patients with Low Performance Status

  • Manoj GuptaEmail author
  • Partha Sarathi Choudhury
  • Sudhir Rawal
  • G. Karthikeyan
  • Vineet Talwar
  • Kumar Deep Dutta
  • Amitabh Singh
Original Article
  • 30 Downloads

Abstract

Purpose

The aim of this study was to evaluate safety and therapeutic efficacy of lutetium 177 prostate-specific membrane antigen (Lu-177-PSMA) in metastatic castration-resistant prostate cancer (mCRPC) patients with low performance status.

Methods

Twenty-two patients already treated with anti-androgens and docetaxel were enrolled for one cycle of Lu-177-PSMA therapy. Haemoglobin, total leukocyte counts, platelets and serum creatinine for toxicity profile while prostate specific antigen (PSA), Eastern Cooperative Oncology Group (ECOG) performance status, visual analogue scale (VAS) and analgesic quantification scale (AQS) for therapeutic efficacy were recorded pre and 8 weeks post therapy. Wilcoxon signed-rank and ANOVA tests were used for statistical analysis.

Results

Partial response (PR), stable disease (SD) and progressive disease (PD) for PSA were seen in 5 (22.7%), 13 (59.1%) and 4 (18.2%) patients respectively treated with mean 6.88 GBq dose of Lu-177-PSMA. 8/22 (36.4%) patients showed ≥ 30% drop in PSA. Grade 3 haemoglobin toxicity was seen in 5/22 (22.7%) patients. No patient developed grade 4 haemoglobin toxicity. No patients had grade 3 or 4 leukocytopenia or thrombocytopenia. Wilcoxon signed-rank test showed statistical significant (P < 0.05) difference in pre and post treatment ECOG, VAS, and AQS scores. The ANOVA test showed statistically significant difference in mean doses of Lu-177-PSMA used in three PSA response groups while difference was non-significant for other variables.

Conclusion

We concluded that Lu-177-PSMA therapy has adequate pain palliation in end-stage mCRPC patients with low performance status and it has a potential to become effective therapeutic option in properly selected patients.

Keywords

Lu-177-PSMA Safety and efficacy Metastatic castration resistant prostate cancer Low performance status 

Notes

Compliance with Ethical Standards

Conflict of Interest

Manoj Gupta, Partha Sarathi Choudhury, Sudhir Rawal, G. Karthikeyan, Vineet Talwar, Kumar Deep Dutta and Amitabh Singh declare that they have no conflict of interest.

Ethical Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

The institutional review board waived the need to obtain informed consent for this retrospective study.

Supplementary material

13139_2019_624_MOESM1_ESM.docx (14 kb)
Supplementary Table 1 (DOCX 13 kb)

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Copyright information

© Korean Society of Nuclear Medicine 2019

Authors and Affiliations

  1. 1.Department of Nuclear MedicineRajiv Gandhi Cancer Institute and Research CentreDelhiIndia
  2. 2.Department of Uro - Gynae Surgical OncologyRajiv Gandhi Cancer Institute and Research CentreDelhiIndia
  3. 3.Amity Institute of Virology and ImmunologyAmity UniversityNoidaIndia
  4. 4.Department of Medical OncologyRajiv Gandhi Cancer Institute and Research CentreDelhiIndia

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