68Ga-PSMA: a One-stop Shop in Radioactive Iodine Refractory Thyroid Cancer?
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We report a case of a 47-year-old female known with metastatic papillary thyroid cancer. Her treatment history included total thyroidectomy and 3 previous radio ablations with a cumulative dose of 950 mCi of 131I. On follow-up, her thyroglobulin levels had demonstrated a rising trend (from 3789.0 to 4240.0 ug/L) despite a 123I whole-body scan demonstrating a reduction in tracer avid lesions. She was suspected of having radio-resistant disease. The patient underwent both 18F-FDG and 68Ga-PSMA PET/CT imaging with both scans demonstrating congruent lesions however with far greater intensity on the 68Ga-PSMA study.
Keywords68Ga-PSMA 18F-FDG Thyroid cancer Radioactive iodine refractory thyroid
We would like to thank the staff of the Department of Nuclear Medicine of Steve Biko Academic Hospital for performing the scans.
This study was self-funded by the Department of Nuclear Medicine.
Compliance with Ethical Standards
Conflict of Interest
Thabo Lengana, Ismaheel O. Lawal, Kgomotso Mokoala, Mariza Vorster, and Mike M. Sathekge declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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