Detection of Solitary Axillary Lymph Node Metastases from Hürthle Cell Carcinoma of the Thyroid on 18F-FDG PET/CT
Thyroid carcinoma is the most common neoplasm of endocrine malignancies. Differentiated thyroid carcinoma (DTC) constitutes 90% of the thyroid carcinomas, rest being medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC). Distant metastases occur in up to 10% of patients with DTC. Metastases to axillary lymph nodes (ALN) are very rare. As per literature, only 25 cases have been reported. We report an unusual case of 47-year-old male with Hürthle cell carcinoma of the thyroid presenting with a solitary axillary lymph node metastasis 17 years after thyroidectomy, along with review of literature.
KeywordsAxillary lymph node metastasis Hürthle cell carcinoma of the thyroid 18F-FDG PET/CT Recurrence
Compliance with Ethical Standards
Conflict of Interest
The authors Meghana Prabhu, Deepali Jain, Siddhartha Datta Gupta, Chandra Sekhar Bal, Rakesh Kumar declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Human and Animal Rights
This chapter does not contain any studies with animals performed by any of the authors.
The institutional review board of our institute approved this retrospective study, and the requirement to obtain informed consent was waived.
Informed consent was obtained from the patient for FDG PET/CT in the study.
- 2.Chiofalo MG, Losito NS, Fulciniti F, Setola SV, Tommaselli A, Marone U, et al. Axillary node metastasis from differentiated thyroid carcinoma with Hürthle and signet cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings. BMC Cancer. 2012;12:55.CrossRefPubMedPubMedCentralGoogle Scholar
- 3.Kamaleshwaran KK, Rajan F, Mohanan V, Shinto AS. Rare case of axillary lymph node metastasis in papillary thyroid carcinoma detected using Iodine-131 whole-body scintigraphy and single-photon emission computed tomography/computed tomography. Indian J Nucl Med. 2015;30:168–70.CrossRefPubMedPubMedCentralGoogle Scholar
- 5.Singhal N, Chaturvedi P, Joshi P, Malik A. Axillary lymph node metastases in differentiated thyroid Cancer “an uncommon presentation with clinical implications”. Austin J Clin Case Rep. 2015;2:1065.Google Scholar
- 7.Koo EJ, Lee MR. Axillary lymph node metastasis of papillary thyroid carcinoma: a case report. Clin Exp Thyroidol. 2014;7:194–200.Google Scholar
- 18.Lal G, Ituarte P, Duh QY, Clark O (2003) The axilla as a rare site of metastatic thyroid cancer with ominous implications (abstract only). 74th Annual meeting of ATA.Google Scholar
- 21.Ueda S, Takahashi H, Akehi S, Nakata T, Satoh N, Kimura S. A case of recurrent thyroid cancer metastasizing to axillary lymph nodes 7 years after the initial thyroidectomy. J Japanese Pract Surg Soc. 1996;57:2934–7.Google Scholar
- 23.Rouviere P. Anatomie des lymphatiques de l'homme. J Am Med Assoc. 1932;99:1716.Google Scholar