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Nuclear Medicine and Molecular Imaging

, Volume 52, Issue 1, pp 24–30 | Cite as

Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies

  • Yoori Choi
  • Seunggyun Ha
  • Yun-Sang Lee
  • Yun Kyung Kim
  • Dong Soo LeeEmail author
  • Dong Jin KimEmail author
Review

Abstract

The pathological features of Alzheimer’s disease are senile plaques which are aggregates of β-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and these induce various other neurodegenerative diseases, such as progressive supranuclear palsy, corticobasal degeneration, frontotemporal lobar degeneration, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and chronic traumatic encephalopathy. In the case of Alzheimer’s disease, the measurement of neurofibrillary tangles associated with cognitive decline is suitable for differential diagnosis, disease progression assessment, and to monitor the effects of therapeutic treatment. This review discusses considerations for the development of tau ligands for imaging and summarizes the results of the first-in-human and preclinical studies of the tau tracers that have been developed thus far. The development of tau ligands for imaging studies will be helpful for differential diagnosis and for the development of therapeutic treatments for tauopathies including Alzheimer’s disease.

Keywords

Tau Alzheimer’s disease Tauopathy Pet Imaging ligands Radiopharmaceutical 

Notes

Compliance with Ethical Standards

Conflict of Interest

Authors Yoori Choi, Seunggyun Ha, Yun-Sang Lee, and Yun Kyung Kim declare that they have no conflict of interest. Author Dong Soo Lee has received research grants from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C0466), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C3344), and funded by the Ministry of Health & Welfare, Republic of Korea (HI14C1277). Author Dong Jin Kim has received a research grant supported by the Brain Research Program through the National Research Foundation of Korea (NRF-2016M3C7A1913845).

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

For this type of study formal consent is not required.

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Copyright information

© Korean Society of Nuclear Medicine 2017

Authors and Affiliations

  1. 1.Department of Nuclear MedicineCollege of Medicine, Seoul National UniversitySeoulSouth Korea
  2. 2.Department of Nuclear MedicineSeoul National University HospitalSeoulSouth Korea
  3. 3.Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of PharmacySeoul National UniversitySeoulSouth Korea
  4. 4.Institute of Brain ScienceKorean Institute of Science and TechnologySeoulSouth Korea

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